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Title: Second-order Kinetics of DTPA and Plutonium in Rat Plasma

Abstract

We report that in 2008, Serandour et al. reported on their in vitro experiment involving rat plasma samples obtained after an intravenous intake of plutonium citrate. Different amounts of DTPA were added to the plasma samples and the percentage of low-molecular-weight plutonium measured. Only when the DTPA dosage was three orders of magnitude greater than the recommended 30 μmol/kg was 100% of the plutonium apparently in the form of chelate. These data were modeled assuming three competing chemical reactions with other molecules that bind with plutonium. Here, time-dependent second-order kinetics of these reactions are calculated, intended eventually to become part of a complete biokinetic model of DTPA action on actinides in laboratory animals or humans. The probability distribution of the ratio of stability constants for the reactants was calculated using Markov Chain Monte Carlo. In conclusion, these calculations substantiate that the inclusion of more reactions is needed in order to be in agreement with known stability constants.

Authors:
 [1]; ORCiD logo [2]; ORCiD logo [2];  [3];  [4]
  1. Santa Fe, NM (United States)
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  3. Ray Guilmette and Associates, LLC, Perry, ME (United States)
  4. Melohill Technology, LLC, Rockville, MD (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1409779
Report Number(s):
LA-UR-17-24631
Journal ID: ISSN 0033-7587
Grant/Contract Number:  
AC52-06NA25396
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Radiation Research
Additional Journal Information:
Journal Volume: 189; Journal Issue: 1; Journal ID: ISSN 0033-7587
Publisher:
Radiation Research Society
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; Radiation Protection

Citation Formats

Miller, Guthrie, Poudel, Deepesh, Klumpp, John Allan, Guilmette, Raymond A., and Melo, Dunstana. Second-order Kinetics of DTPA and Plutonium in Rat Plasma. United States: N. p., 2017. Web. doi:10.1667/RR14852.1.
Miller, Guthrie, Poudel, Deepesh, Klumpp, John Allan, Guilmette, Raymond A., & Melo, Dunstana. Second-order Kinetics of DTPA and Plutonium in Rat Plasma. United States. doi:10.1667/RR14852.1.
Miller, Guthrie, Poudel, Deepesh, Klumpp, John Allan, Guilmette, Raymond A., and Melo, Dunstana. Wed . "Second-order Kinetics of DTPA and Plutonium in Rat Plasma". United States. doi:10.1667/RR14852.1.
@article{osti_1409779,
title = {Second-order Kinetics of DTPA and Plutonium in Rat Plasma},
author = {Miller, Guthrie and Poudel, Deepesh and Klumpp, John Allan and Guilmette, Raymond A. and Melo, Dunstana},
abstractNote = {We report that in 2008, Serandour et al. reported on their in vitro experiment involving rat plasma samples obtained after an intravenous intake of plutonium citrate. Different amounts of DTPA were added to the plasma samples and the percentage of low-molecular-weight plutonium measured. Only when the DTPA dosage was three orders of magnitude greater than the recommended 30 μmol/kg was 100% of the plutonium apparently in the form of chelate. These data were modeled assuming three competing chemical reactions with other molecules that bind with plutonium. Here, time-dependent second-order kinetics of these reactions are calculated, intended eventually to become part of a complete biokinetic model of DTPA action on actinides in laboratory animals or humans. The probability distribution of the ratio of stability constants for the reactants was calculated using Markov Chain Monte Carlo. In conclusion, these calculations substantiate that the inclusion of more reactions is needed in order to be in agreement with known stability constants.},
doi = {10.1667/RR14852.1},
journal = {Radiation Research},
number = 1,
volume = 189,
place = {United States},
year = {Wed Nov 15 00:00:00 EST 2017},
month = {Wed Nov 15 00:00:00 EST 2017}
}

Journal Article:
Free Publicly Available Full Text
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