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Title: Hexagonally Ordered Arrays of α-Helical Bundles Formed from Peptide-Dendron Hybrids

Abstract

Combining monodisperse building blocks that have distinct folding properties serves as a modular strategy for controlling structural complexity in hierarchically organized materials. We combine an α-helical bundle-forming peptide with self-assembling dendrons to better control the arrangement of functional groups within cylindrical nanostructures. Site-specific grafting of dendrons to amino acid residues on the exterior of the α-helical bundle yields monodisperse macromolecules with programmable folding and self-assembly properties. The resulting hybrid biomaterials form thermotropic columnar hexagonal mesophases in which the peptides adopt an α-helical conformation. Bundling of the α-helical peptides accompanies self-assembly of the peptide-dendron hybrids into cylindrical nanostructures. The bundle stoichiometry in the mesophase agrees well with the size found in solution for α-helical bundles of peptides with a similar amino acid sequence.

Authors:
 [1];  [2];  [1];  [1];  [1];  [1]; ORCiD logo [3]; ORCiD logo [2]; ORCiD logo [1]
  1. Department of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States
  2. Department of Chemical and Environmental Engineering, Yale University, New Haven, Connecticut 06511, United States
  3. Department of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States; Department of Materials Science and Engineering, Stony Brook University, Stony Brook, New York 11794, United States
Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1409556
Report Number(s):
BNL-114608-2017-JA¿¿¿
Journal ID: ISSN 0002-7863
DOE Contract Number:  
SC0012704
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of the American Chemical Society; Journal Volume: 139; Journal Issue: 44
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Barkley, Deborah A., Rokhlenko, Yekaterina, Marine, Jeannette E., David, Rachelle, Sahoo, Dipankar, Watson, Matthew D., Koga, Tadanori, Osuji, Chinedum O., and Rudick, Jonathan G. Hexagonally Ordered Arrays of α-Helical Bundles Formed from Peptide-Dendron Hybrids. United States: N. p., 2017. Web. doi:10.1021/jacs.7b09737.
Barkley, Deborah A., Rokhlenko, Yekaterina, Marine, Jeannette E., David, Rachelle, Sahoo, Dipankar, Watson, Matthew D., Koga, Tadanori, Osuji, Chinedum O., & Rudick, Jonathan G. Hexagonally Ordered Arrays of α-Helical Bundles Formed from Peptide-Dendron Hybrids. United States. doi:10.1021/jacs.7b09737.
Barkley, Deborah A., Rokhlenko, Yekaterina, Marine, Jeannette E., David, Rachelle, Sahoo, Dipankar, Watson, Matthew D., Koga, Tadanori, Osuji, Chinedum O., and Rudick, Jonathan G. Tue . "Hexagonally Ordered Arrays of α-Helical Bundles Formed from Peptide-Dendron Hybrids". United States. doi:10.1021/jacs.7b09737.
@article{osti_1409556,
title = {Hexagonally Ordered Arrays of α-Helical Bundles Formed from Peptide-Dendron Hybrids},
author = {Barkley, Deborah A. and Rokhlenko, Yekaterina and Marine, Jeannette E. and David, Rachelle and Sahoo, Dipankar and Watson, Matthew D. and Koga, Tadanori and Osuji, Chinedum O. and Rudick, Jonathan G.},
abstractNote = {Combining monodisperse building blocks that have distinct folding properties serves as a modular strategy for controlling structural complexity in hierarchically organized materials. We combine an α-helical bundle-forming peptide with self-assembling dendrons to better control the arrangement of functional groups within cylindrical nanostructures. Site-specific grafting of dendrons to amino acid residues on the exterior of the α-helical bundle yields monodisperse macromolecules with programmable folding and self-assembly properties. The resulting hybrid biomaterials form thermotropic columnar hexagonal mesophases in which the peptides adopt an α-helical conformation. Bundling of the α-helical peptides accompanies self-assembly of the peptide-dendron hybrids into cylindrical nanostructures. The bundle stoichiometry in the mesophase agrees well with the size found in solution for α-helical bundles of peptides with a similar amino acid sequence.},
doi = {10.1021/jacs.7b09737},
journal = {Journal of the American Chemical Society},
number = 44,
volume = 139,
place = {United States},
year = {Tue Oct 24 00:00:00 EDT 2017},
month = {Tue Oct 24 00:00:00 EDT 2017}
}