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Title: Eye patches: Protein assembly of index-gradient squid lenses

Abstract

A parabolic relationship between lens radius and refractive index allows spherical lenses to avoid spherical aberration. We show that in squid, patchy colloidal physics resulted from an evolutionary radiation of globular S-crystallin proteins. Small-angle x-ray scattering experiments on lens tissue show colloidal gels of S-crystallins at all radial positions. Sparse lens materials form via low-valence linkages between disordered loops protruding from the protein surface. The loops are polydisperse and bind via a set of hydrogen bonds between disordered side chains. Peripheral lens regions with low particle valence form stable, volume-spanning gels at low density, whereas central regions with higher average valence gel at higher densities. The proteins demonstrate an evolved set of linkers for self-assembly of nanoparticles into volumetric materials.

Authors:
ORCiD logo; ORCiD logo; ORCiD logo; ; ORCiD logo
Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1409547
Report Number(s):
BNL-114599-2017-JA¿¿¿
Journal ID: ISSN 0036-8075
DOE Contract Number:  
SC0012704
Resource Type:
Journal Article
Resource Relation:
Journal Name: Science; Journal Volume: 357; Journal Issue: 6351
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Cai, J., Townsend, J. P., Dodson, T. C., Heiney, P. A., and Sweeney, A. M.. Eye patches: Protein assembly of index-gradient squid lenses. United States: N. p., 2017. Web. doi:10.1126/science.aal2674.
Cai, J., Townsend, J. P., Dodson, T. C., Heiney, P. A., & Sweeney, A. M.. Eye patches: Protein assembly of index-gradient squid lenses. United States. doi:10.1126/science.aal2674.
Cai, J., Townsend, J. P., Dodson, T. C., Heiney, P. A., and Sweeney, A. M.. Thu . "Eye patches: Protein assembly of index-gradient squid lenses". United States. doi:10.1126/science.aal2674.
@article{osti_1409547,
title = {Eye patches: Protein assembly of index-gradient squid lenses},
author = {Cai, J. and Townsend, J. P. and Dodson, T. C. and Heiney, P. A. and Sweeney, A. M.},
abstractNote = {A parabolic relationship between lens radius and refractive index allows spherical lenses to avoid spherical aberration. We show that in squid, patchy colloidal physics resulted from an evolutionary radiation of globular S-crystallin proteins. Small-angle x-ray scattering experiments on lens tissue show colloidal gels of S-crystallins at all radial positions. Sparse lens materials form via low-valence linkages between disordered loops protruding from the protein surface. The loops are polydisperse and bind via a set of hydrogen bonds between disordered side chains. Peripheral lens regions with low particle valence form stable, volume-spanning gels at low density, whereas central regions with higher average valence gel at higher densities. The proteins demonstrate an evolved set of linkers for self-assembly of nanoparticles into volumetric materials.},
doi = {10.1126/science.aal2674},
journal = {Science},
number = 6351,
volume = 357,
place = {United States},
year = {Thu Aug 10 00:00:00 EDT 2017},
month = {Thu Aug 10 00:00:00 EDT 2017}
}