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Title: Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models

Journal Article · · International Journal of Molecular Sciences (Online)
DOI:https://doi.org/10.3390/ijms18050932· OSTI ID:1408431
 [1];  [2];  [1];  [1];  [3];  [4];  [1];  [1]
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division
  2. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division; Nanjing Medical Univ. (China). Drum Tower Clinical Medical School. Dept. of Gastroenterology
  3. Monogram Biosciences Inc., South San Francisco, CA (United States)
  4. Nanjing Medical Univ. (China). State Key Lab. of Reproductive Medicine. Inst. of Toxicology
+ Show Author Affiliations

The newly identified smoke hazard, thirdhand smoke (THS), has gained public attention in recent years but its health impact and biological effects are largely unknown. THS may be defined by “the four Rs”: tobacco chemicals that remain, react, re-emit, and/or are resuspended long after active smoking has ceased. This review summarizes recent research progress in the effects of THS on genotoxicity, metabolism and early life development using cellular and animal models. We first reported that THS generated in laboratory systems caused significant DNA damage in human cell lines. Our finding that THS significantly induces oxidative base lesions has been confirmed in skin wounds of mice models exposed to THS. THS also induced metabolomic changes in human reproductive cell lines. Furthermore, we demonstrated that early exposure to THS not only negatively impacts body weight in both male and female mice, but also induces persistent changes to immunological parameters in peripheral blood in these mice. These results indicate that THS is genotoxic at realistic experimental doses and that there may be a window of susceptibility for some forms of cellular damage induced by THS.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE; Univ. of California Tobacco-Related Disease Research Program (TRDRP)
Grant/Contract Number:
AC02-05CH11231; 19XT-0070; 20PT-0184H; 24RT-0038
OSTI ID:
1408431
Journal Information:
International Journal of Molecular Sciences (Online), Vol. 18, Issue 5; ISSN 1422-0067
Publisher:
MDPICopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 22 works
Citation information provided by
Web of Science

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Cited By (2)

Smoking and pregnancy: Epigenetics and developmental origins of the metabolic syndrome journal July 2019
Medical staff contributions to thirdhand smoke contamination in a neonatal intensive care unit journal April 2019

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
thirdhand smoke
secondhand smoke
DNA damage
DNA strand breaks
DNA adducts
genotoxicity
early exposure
animal studies
health impact
tobacco control