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Title: Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models

Abstract

The newly identified smoke hazard, thirdhand smoke (THS), has gained public attention in recent years but its health impact and biological effects are largely unknown. THS may be defined by “the four Rs”: tobacco chemicals that remain, react, re-emit, and/or are resuspended long after active smoking has ceased. This review summarizes recent research progress in the effects of THS on genotoxicity, metabolism and early life development using cellular and animal models. We first reported that THS generated in laboratory systems caused significant DNA damage in human cell lines. Our finding that THS significantly induces oxidative base lesions has been confirmed in skin wounds of mice models exposed to THS. THS also induced metabolomic changes in human reproductive cell lines. Furthermore, we demonstrated that early exposure to THS not only negatively impacts body weight in both male and female mice, but also induces persistent changes to immunological parameters in peripheral blood in these mice. These results indicate that THS is genotoxic at realistic experimental doses and that there may be a window of susceptibility for some forms of cellular damage induced by THS.

Authors:
 [1];  [2];  [1];  [1];  [3];  [4];  [1];  [1]
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division
  2. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division; Nanjing Medical Univ. (China). Drum Tower Clinical Medical School. Dept. of Gastroenterology
  3. Monogram Biosciences Inc., South San Francisco, CA (United States)
  4. Nanjing Medical Univ. (China). State Key Lab. of Reproductive Medicine. Inst. of Toxicology
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE; Univ. of California Tobacco-Related Disease Research Program (TRDRP)
OSTI Identifier:
1408431
Grant/Contract Number:
AC02-05CH11231; 19XT-0070; 20PT-0184H; 24RT-0038
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
International Journal of Molecular Sciences (Online)
Additional Journal Information:
Journal Name: International Journal of Molecular Sciences (Online); Journal Volume: 18; Journal Issue: 5; Journal ID: ISSN 1422-0067
Publisher:
MDPI
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; thirdhand smoke; secondhand smoke; DNA damage; DNA strand breaks; DNA adducts; genotoxicity; early exposure; animal studies; health impact; tobacco control

Citation Formats

Hang, Bo, Wang, Pin, Zhao, Yue, Sarker, Altaf, Chenna, Ahmed, Xia, Yankai, Snijders, Antoine M., and Mao, Jian-Hua. Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models. United States: N. p., 2017. Web. doi:10.3390/ijms18050932.
Hang, Bo, Wang, Pin, Zhao, Yue, Sarker, Altaf, Chenna, Ahmed, Xia, Yankai, Snijders, Antoine M., & Mao, Jian-Hua. Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models. United States. doi:10.3390/ijms18050932.
Hang, Bo, Wang, Pin, Zhao, Yue, Sarker, Altaf, Chenna, Ahmed, Xia, Yankai, Snijders, Antoine M., and Mao, Jian-Hua. Fri . "Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models". United States. doi:10.3390/ijms18050932. https://www.osti.gov/servlets/purl/1408431.
@article{osti_1408431,
title = {Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models},
author = {Hang, Bo and Wang, Pin and Zhao, Yue and Sarker, Altaf and Chenna, Ahmed and Xia, Yankai and Snijders, Antoine M. and Mao, Jian-Hua},
abstractNote = {The newly identified smoke hazard, thirdhand smoke (THS), has gained public attention in recent years but its health impact and biological effects are largely unknown. THS may be defined by “the four Rs”: tobacco chemicals that remain, react, re-emit, and/or are resuspended long after active smoking has ceased. This review summarizes recent research progress in the effects of THS on genotoxicity, metabolism and early life development using cellular and animal models. We first reported that THS generated in laboratory systems caused significant DNA damage in human cell lines. Our finding that THS significantly induces oxidative base lesions has been confirmed in skin wounds of mice models exposed to THS. THS also induced metabolomic changes in human reproductive cell lines. Furthermore, we demonstrated that early exposure to THS not only negatively impacts body weight in both male and female mice, but also induces persistent changes to immunological parameters in peripheral blood in these mice. These results indicate that THS is genotoxic at realistic experimental doses and that there may be a window of susceptibility for some forms of cellular damage induced by THS.},
doi = {10.3390/ijms18050932},
journal = {International Journal of Molecular Sciences (Online)},
number = 5,
volume = 18,
place = {United States},
year = {Fri Apr 28 00:00:00 EDT 2017},
month = {Fri Apr 28 00:00:00 EDT 2017}
}

Journal Article:
Free Publicly Available Full Text
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  • The use of wood stoves has increased greatly in the past decade, causing concern in many communities about the health effects of wood smoke. Wood smoke is known to contain such compounds as carbon monoxide, nitrogen oxides, sulfur oxides, aldehydes, polycyclic aromatic hydrocarbons, and fine respirable particulate matter. All of these have been shown to cause deleterious physiologic responses in laboratory studies in humans. Some compounds found in wood smoke--benzo(a)pyrene and formaldehyde--are possible human carcinogens. Fine particulate matter has been associated with decreased pulmonary function in children and with increased chronic lung disease in Nepal, where exposure to very highmore » amounts of wood smoke occurs in residences. Wood smoke fumes, taken from both outdoor and indoor samples, have shown mutagenic activity in short-term bioassay tests. Because of the potential health effects of wood smoke, exposure to this source of air pollution should be minimal.29 references.« less
  • No abstract available.
  • Thirdhand smoke (THS) is the fraction of cigarette smoke that persists in indoor environments after smoking. We investigated the effects of neonatal and adult THS exposure on bodyweight and blood cell populations in C57BL/6 J mice. At the end of neonatal exposure, THS-treated male and female mice had significantly lower bodyweight than their respective control mice. However, five weeks after neonatal exposure ended, THS-treated mice weighed the same as controls. In contrast, adult THS exposure did not change bodyweight of mice. On the other hand, both neonatal and adult THS exposure had profound effects on the hematopoietic system. Fourteen weeksmore » after neonatal THS exposure ended, eosinophil number and platelet volume were significantly higher, while hematocrit, mean cell volume, and platelet counts were significantly lower compared to control. Similarly, adult THS exposure also decreased platelet counts and increased neutrophil counts. Moreover, both neonatal and adult THS exposure caused a significant increase in percentage of B-cells and significantly decreased percentage of myeloid cells. Our results demonstrate that neonatal THS exposure decreases bodyweight and that THS exposure induces persistent changes in the hematopoietic system independent of age at exposure. These results also suggest that THS exposure may have adverse effects on human health.« less
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