Calcium Coordination Solids for pH-Triggered Release of Olsalazine

Levine, Dana J.; Gonzalez, Miguel I.; Legendre, Christina M.; Runcevski, Tomce; Oktawiec, Julia; Colwell, Kristen A.; Long, Jeffrey R.

doi:10.1002/cmdc.201700540

Title: Calcium Coordination Solids for pH-Triggered Release of Olsalazine

Journal Article · Tue Sep 12 00:00:00 EDT 2017 · ChemMedChem

DOI:https://doi.org/10.1002/cmdc.201700540· OSTI ID:1420116

^[1];

^[2]; Legendre, Christina M. ^[2]; Runcevski, Tomce ^[3];

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^[3]

Univ. of California, Berkeley, CA (United States); California Inst. of Technology (CalTech), Pasadena, CA (United States)
Univ. of California, Berkeley, CA (United States)
Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Abstract Calcium coordination solids were synthesized and evaluated for delivery of olsalazine (H ₄ olz), an anti‐inflammatory compound used for treatment of ulcerative colitis. The materials include one‐dimensional Ca(H ₂ olz)⋅4 H ₂ O chains, two‐dimensional Ca(H ₂ olz)⋅2 H ₂ O sheets, and a three‐dimensional metal‐organic framework Ca(H ₂ olz)⋅2DMF (DMF= N , N ‐dimethylformamide). The framework undergoes structural changes in response to solvent, forming a dense Ca(H ₂ olz) phase when exposed to aqueous HCl. The compounds Ca(H ₂ olz)⋅ x H ₂ O ( x =0, 2, 4) were each pressed into pellets and exposed to simulated gastrointestinal fluids to mimic the passage of a pill from the acidic stomach to the pH‐neutral intestines. All three calcium materials exhibited a delayed release of olsalazine relative to Na ₂ (H ₂ olz), the commercial formulation, illustrating how formulation of a drug within an extended coordination solid can serve to tune its solubility and performance.

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Research Organization:: Energy Frontier Research Centers (EFRC) (United States). Center for Gas Separations Relevant to Clean Energy Technologies (CGS); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1420116

Alternate ID(s):: OSTI ID: 1407822

Journal Information:: ChemMedChem, Vol. 12, Issue 21; ISSN 1860-7179

Publisher:: ChemPubSoc EuropeCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 4 works

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