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Title: Estimation of the Maximum Theoretical Productivity of Fed-Batch Bioreactors

Abstract

A key step towards the development of an integrated biorefinery is the screening of economically viable processes, which depends sharply on the yields and productivities that can be achieved by an engineered microorganism. In this study, we extend an earlier method which used dynamic optimization to find the maximum theoretical productivity of batch cultures to explicitly include fed-batch bioreactors. In addition to optimizing the intracellular distribution of metabolites between cell growth and product formation, we calculate the optimal control trajectory of feed rate versus time. We further analyze how sensitive the productivity is to substrate uptake and growth parameters.

Authors:
 [1]; ORCiD logo [1];  [1]
  1. National Renewable Energy Laboratory (NREL), Golden, CO (United States)
Publication Date:
Research Org.:
National Renewable Energy Lab. (NREL), Golden, CO (United States)
Sponsoring Org.:
USDOE Office of Energy Efficiency and Renewable Energy (EERE), Bioenergy Technologies Office (EE-3B)
OSTI Identifier:
1407459
Report Number(s):
NREL/CP-2700-70447
DOE Contract Number:
AC36-08GO28308
Resource Type:
Conference
Resource Relation:
Conference: Presented at the 20th IFAC World Congress, 9-14 July 2017, Toulouse, France
Country of Publication:
United States
Language:
English
Subject:
09 BIOMASS FUELS; fermentation processes; open-loop control systems; optimal control; nonlinear programming

Citation Formats

Bomble, Yannick J, St. John, Peter C, and Crowley, Michael F. Estimation of the Maximum Theoretical Productivity of Fed-Batch Bioreactors. United States: N. p., 2017. Web. doi:10.1016/j.ifacol.2017.08.1605.
Bomble, Yannick J, St. John, Peter C, & Crowley, Michael F. Estimation of the Maximum Theoretical Productivity of Fed-Batch Bioreactors. United States. doi:10.1016/j.ifacol.2017.08.1605.
Bomble, Yannick J, St. John, Peter C, and Crowley, Michael F. Wed . "Estimation of the Maximum Theoretical Productivity of Fed-Batch Bioreactors". United States. doi:10.1016/j.ifacol.2017.08.1605.
@article{osti_1407459,
title = {Estimation of the Maximum Theoretical Productivity of Fed-Batch Bioreactors},
author = {Bomble, Yannick J and St. John, Peter C and Crowley, Michael F},
abstractNote = {A key step towards the development of an integrated biorefinery is the screening of economically viable processes, which depends sharply on the yields and productivities that can be achieved by an engineered microorganism. In this study, we extend an earlier method which used dynamic optimization to find the maximum theoretical productivity of batch cultures to explicitly include fed-batch bioreactors. In addition to optimizing the intracellular distribution of metabolites between cell growth and product formation, we calculate the optimal control trajectory of feed rate versus time. We further analyze how sensitive the productivity is to substrate uptake and growth parameters.},
doi = {10.1016/j.ifacol.2017.08.1605},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Oct 18 00:00:00 EDT 2017},
month = {Wed Oct 18 00:00:00 EDT 2017}
}

Conference:
Other availability
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