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Title: Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions

Abstract

A barrier structure for use in an electrochemical stochastic membrane sensor for single molecule detection. The sensor is based upon inorganic nanopores having electrically tunable dimensions. The inorganic nanopores are formed from inorganic materials and an electrically conductive polymer. Methods of making the barrier structure and sensing single molecules using the barrier structure are also described.

Inventors:
; ; ; ;
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1406520
Patent Number(s):
RE46,594
Application Number:
14/289,445
Assignee:
LOS ALAMOS NATIONAL SECURITY, LLC LANL
DOE Contract Number:
AC52-06NA25396
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 May 28
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Sansinena, Jose-Maria, Redondo, Antonio, Olazabal, Virginia, Hoffbauer, Mark A., and Akhadov, Elshan A.. Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions. United States: N. p., 2017. Web.
Sansinena, Jose-Maria, Redondo, Antonio, Olazabal, Virginia, Hoffbauer, Mark A., & Akhadov, Elshan A.. Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions. United States.
Sansinena, Jose-Maria, Redondo, Antonio, Olazabal, Virginia, Hoffbauer, Mark A., and Akhadov, Elshan A.. Tue . "Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions". United States. doi:. https://www.osti.gov/servlets/purl/1406520.
@article{osti_1406520,
title = {Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions},
author = {Sansinena, Jose-Maria and Redondo, Antonio and Olazabal, Virginia and Hoffbauer, Mark A. and Akhadov, Elshan A.},
abstractNote = {A barrier structure for use in an electrochemical stochastic membrane sensor for single molecule detection. The sensor is based upon inorganic nanopores having electrically tunable dimensions. The inorganic nanopores are formed from inorganic materials and an electrically conductive polymer. Methods of making the barrier structure and sensing single molecules using the barrier structure are also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 31 00:00:00 EDT 2017},
month = {Tue Oct 31 00:00:00 EDT 2017}
}

Patent:

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  • A barrier structure for use in an electrochemical stochastic membrane sensor for single molecule detection. The sensor is based upon inorganic nanopores having electrically tunable dimensions. The inorganic nanopores are formed from inorganic materials and an electrically conductive polymer. Methods of making the barrier structure and sensing single molecules using the barrier structure are also described.
  • A barrier structure for use in an electrochemical stochastic membrane sensor for single molecule detection. The sensor is based upon inorganic nanopores having electrically tunable dimensions. The inorganic nanopores are formed from inorganic materials and an electrically conductive polymer. Methods of making the barrier structure and sensing single molecules using the barrier structure are also described.
  • A barrier structure for use in an electrochemical stochastic membrane sensor for single molecule detection. The sensor is based upon inorganic nanopores having electrically tunable dimensions. The inorganic nanopores are formed from inorganic materials and an electrically conductive polymer. Methods of making the barrier structure and sensing single molecules using the barrier structure are also described.
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  • An apparatus for carrying out the separation, detection, and/or counting of single molecules at nanometer scale. Molecular separation is achieved by driving single molecules through a microfluidic or nanofluidic medium using programmable and coordinated electric fields. In various embodiments, the fluidic medium is a strip of hydrophilic material on nonconductive hydrophobic surface, a trough produced by parallel strips of hydrophobic nonconductive material on a hydrophilic base, or a covered passageway produced by parallel strips of hydrophobic nonconductive material on a hydrophilic base together with a nonconductive cover on the parallel strips of hydrophobic nonconductive material. The molecules are detected andmore » counted using nanoelectrode-gated electron tunneling methods, dielectric monitoring, and other methods.« less