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Title: Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions

Abstract

A barrier structure for use in an electrochemical stochastic membrane sensor for single molecule detection. The sensor is based upon inorganic nanopores having electrically tunable dimensions. The inorganic nanopores are formed from inorganic materials and an electrically conductive polymer. Methods of making the barrier structure and sensing single molecules using the barrier structure are also described.

Inventors:
; ; ; ;
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1406520
Patent Number(s):
RE46,594
Application Number:
14/289,445
Assignee:
LOS ALAMOS NATIONAL SECURITY, LLC LANL
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 May 28
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Sansinena, Jose-Maria, Redondo, Antonio, Olazabal, Virginia, Hoffbauer, Mark A., and Akhadov, Elshan A. Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions. United States: N. p., 2017. Web.
Sansinena, Jose-Maria, Redondo, Antonio, Olazabal, Virginia, Hoffbauer, Mark A., & Akhadov, Elshan A. Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions. United States.
Sansinena, Jose-Maria, Redondo, Antonio, Olazabal, Virginia, Hoffbauer, Mark A., and Akhadov, Elshan A. Tue . "Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions". United States. doi:. https://www.osti.gov/servlets/purl/1406520.
@article{osti_1406520,
title = {Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions},
author = {Sansinena, Jose-Maria and Redondo, Antonio and Olazabal, Virginia and Hoffbauer, Mark A. and Akhadov, Elshan A.},
abstractNote = {A barrier structure for use in an electrochemical stochastic membrane sensor for single molecule detection. The sensor is based upon inorganic nanopores having electrically tunable dimensions. The inorganic nanopores are formed from inorganic materials and an electrically conductive polymer. Methods of making the barrier structure and sensing single molecules using the barrier structure are also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 31 00:00:00 EDT 2017},
month = {Tue Oct 31 00:00:00 EDT 2017}
}

Patent:

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Works referenced in this record:

Microarray Device
patent-application, December 2008


A biosensor that uses ion-channel switches
June 1997


Conducting polymer polypyrrole supported bilayer lipid membranes
journal, January 2005

  • Shao, Yong; Jin, Yongdong; Wang, Jianlong
  • Biosensors and Bioelectronics, Vol. 20, Issue 7, p. 1373-1379
  • DOI: 10.1016/j.bios.2004.06.001

Reversible Conversion of Conducting Polymer Films from Superhydrophobic to Superhydrophilic
journal, September 2005

  • Xu, Lianbin; Chen, Wilfred; Mulchandani, Ashok
  • Angewandte Chemie International Edition, Vol. 44, Issue 37, p. 6009-6012
  • DOI: 10.1002/anie.200500868

Continuous base identification for single-molecule nanopore DNA sequencing
journal, February 2009

  • Clarke, James; Wu, Hai-Chen; Jayasinghe, Lakmal
  • Nature Nanotechnology, Vol. 4, Issue 4, p. 265-270
  • DOI: 10.1038/nnano.2009.12

Electrooxidative Deposition of Polypyrrole and Polyaniline on Self-Assembled Monolayer Modified Electrodes
journal, February 1997

  • Sayre, Curtis N.; Collard, David M.
  • Langmuir, Vol. 13, Issue 4, p. 714-722
  • DOI: 10.1021/la960420v

Stochastic sensors inspired by biology
journal, September 2001

  • Bayley, Hagan; Cremer, Paul S.
  • Nature, Vol. 413, Issue 6852, p. 226-230
  • DOI: 10.1038/35093038

Synthesis of heterosegment-junctioned hybrid nanotubes of polythiophene and heterometallic nanoparticles by sequential template-based electropolymerization
journal, January 2011

  • Awaji, Hiroshi; Nakahodo, Tsukasa; Fujihara, Hisashi
  • Chemical Communications, Vol. 47, Issue 12, p. 3547-3549
  • DOI: 10.1039/C0CC04235H

Stochastic Sensing with Protein Pores
journal, January 2000


Resistive-Pulse Sensing - From Microbes to Molecules
journal, July 2000

  • Bayley, Hagan; Martin, Charles R.
  • Chemical Reviews, Vol. 100, Issue 7, p. 2575-2594
  • DOI: 10.1021/cr980099g

Single Ion Channel Sensitivity in Suspended Bilayers on Micromachined Supports
journal, February 2001

  • Cheng, Yaling; Bushby, Richard J.; Evans, Stephen D.
  • Langmuir, Vol. 17, Issue 4, p. 1240-1242
  • DOI: 10.1021/la001423h

An Asymmetric Polymer Nanopore for Single Molecule Detection
journal, March 2004

  • Mara, Abraham; Siwy, Zuzanna; Trautmann, Christina
  • Nano Letters, Vol. 4, Issue 3, p. 497-501
  • DOI: 10.1021/nl035141o

Ion-beam sculpting at nanometre length scales
journal, July 2001

  • Li, Jiali; Stein, Derek; McMullan, Ciaran
  • Nature, Vol. 412, Issue 6843, p. 166-169
  • DOI: 10.1038/35084037

An Artificial Nanopore for Molecular Sensing
journal, January 2003

  • Saleh, Omar A.; Sohn, Lydia L.
  • Nano Letters, Vol. 3, Issue 1, p. 37-38
  • DOI: 10.1021/nl0255202