Electron Bifurcation Makes the Puzzle Pieces Fall Energetically into Place in Methanogenic Energy Conservation

Lubner, Carolyn E.; Peters, John W.

doi:10.1002/cbic.201700533

Title: Electron Bifurcation Makes the Puzzle Pieces Fall Energetically into Place in Methanogenic Energy Conservation

Journal Article · Fri Oct 06 00:00:00 EDT 2017 · ChemBioChem: a European journal of chemical biology

DOI:https://doi.org/10.1002/cbic.201700533· OSTI ID:1405273

^[1];

^[2]

National Renewable Energy Lab. (NREL), Golden, CO (United States). Biosciences Center
Washington State Univ., Pullman, WA (United States). Inst. of Biological Chemistry

Microbial life has evolved a wide range of metabolisms exploiting in many cases unanticipated suites of oxidation-reduction reactions to generate energy. Although many of these suites of reactions don't allow these microbes to enjoy the same quality of energetic life that we enjoy via respiration/oxidative phosphorylation, it has conferred the ability for life to exploit almost any oxidation-reduction reaction. We find in many of these cases when energy is sparing, the difference between life and death may be conserving the maximal amount of energy and minimizing loss of free energy through heat.

View Accepted Manuscript (DOE)

View Accepted Manuscript (Publisher)

Cite

Export

Save

Research Organization:: National Renewable Energy Laboratory (NREL), Golden, CO (United States); Energy Frontier Research Centers (EFRC) (United States). Center for Biological Electron Transfer and Catalysis (BETCy)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC36-08GO28308; SC0012518

OSTI ID:: 1405273

Alternate ID(s):: OSTI ID: 1407814

Report Number(s):: NREL/JA-2700-70292

Journal Information:: ChemBioChem: a European journal of chemical biology, Vol. 18, Issue 23; ISSN 1439-4227

Publisher:: ChemPubSoc EuropeCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 10 works

Citation information provided by
Web of Science

References (18)

Mechanism for electron transfer within and between proteins Page, C. Current Opinion in Chemical Biology, Vol. 7, Issue 5 https://doi.org/10.1016/j.cbpa.2003.08.005	journal	October 2003
Methanogenic archaea: ecologically relevant differences in energy conservation Thauer, Rudolf K.; Kaster, Anne-Kristin; Seedorf, Henning Nature Reviews Microbiology, Vol. 6, Issue 8 https://doi.org/10.1038/nrmicro1931	journal	June 2008
Methanobacillus omelianskii, a symbiotic association of two species of bacteria Bryant, M. P.; Wolin, E. A.; Wolin, M. J. Archiv f�r Mikrobiologie, Vol. 59, Issue 1-3 https://doi.org/10.1007/BF00406313	journal	January 1967
Insights into Flavin-based Electron Bifurcation via the NADH-dependent Reduced Ferredoxin:NADP Oxidoreductase Structure Demmer, Julius K.; Huang, Haiyan; Wang, Shuning Journal of Biological Chemistry, Vol. 290, Issue 36 https://doi.org/10.1074/jbc.M115.656520	journal	July 2015
A Ferredoxin- and F ₄₂₀ H ₂ -Dependent, Electron-Bifurcating, Heterodisulfide Reductase with Homologs in the Domains Bacteria and Archaea Yan, Zhen; Wang, Mingyu; Ferry, James G. mBio, Vol. 8, Issue 1 https://doi.org/10.1128/mBio.02285-16	journal	February 2017
VhuD Facilitates Electron Flow from H2 or Formate to Heterodisulfide Reductase in Methanococcus maripaludis Costa, K. C.; Lie, T. J.; Xia, Q. Journal of Bacteriology, Vol. 195, Issue 22 https://doi.org/10.1128/JB.00895-13	journal	September 2013
Mechanistic insights into energy conservation by flavin-based electron bifurcation Lubner, Carolyn E.; Jennings, David P.; Mulder, David W. Nature Chemical Biology, Vol. 13, Issue 6 https://doi.org/10.1038/nchembio.2348	journal	April 2017
Electron Bifurcation: Thermodynamics and Kinetics of Two-Electron Brokering in Biological Redox Chemistry Zhang, Peng; Yuly, Jonathon L.; Lubner, Carolyn E. Accounts of Chemical Research, Vol. 50, Issue 9 https://doi.org/10.1021/acs.accounts.7b00327	journal	August 2017
Methanogenic heterodisulfide reductase (HdrABC-MvhAGD) uses two noncubane [4Fe-4S] clusters for reduction Wagner, Tristan; Koch, Jürgen; Ermler, Ulrich Science, Vol. 357, Issue 6352 https://doi.org/10.1126/science.aan0425	journal	August 2017
Heterodisulfide reductase from Methanothermobacter marburgensis contains an active-site [4Fe-4S] cluster that is directly involved in mediating heterodisulfide reduction Duin, Evert C.; Madadi-Kahkesh, Shahla; Hedderich, Reiner FEBS Letters, Vol. 512, Issue 1-3 https://doi.org/10.1016/S0014-5793(02)02281-0	journal	January 2002
Protein complexing in a methanogen suggests electron bifurcation and electron delivery from formate to heterodisulfide reductase Costa, K. C.; Wong, P. M.; Wang, T. Proceedings of the National Academy of Sciences, Vol. 107, Issue 24 https://doi.org/10.1073/pnas.1003653107	journal	June 2010
The protonmotive Q cycle: A general formulation Mitchell, Peter FEBS Letters, Vol. 59, Issue 2 https://doi.org/10.1016/0014-5793(75)80359-0	journal	November 1975
Hydrogenases from Methanogenic Archaea, Nickel, a Novel Cofactor, and H ₂ Storage Thauer, Rudolf K.; Kaster, Anne-Kristin; Goenrich, Meike Annual Review of Biochemistry, Vol. 79, Issue 1 https://doi.org/10.1146/annurev.biochem.030508.152103	journal	June 2010
Energy conservation via electron bifurcating ferredoxin reduction and proton/Na+ translocating ferredoxin oxidation Buckel, Wolfgang; Thauer, Rudolf K. Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1827, Issue 2 https://doi.org/10.1016/j.bbabio.2012.07.002	journal	February 2013
Studies on the Mechanism of Electron Bifurcation Catalyzed by Electron Transferring Flavoprotein (Etf) and Butyryl-CoA Dehydrogenase (Bcd) of Acidaminococcus fermentans Chowdhury, Nilanjan Pal; Mowafy, Amr M.; Demmer, Julius K. Journal of Biological Chemistry, Vol. 289, Issue 8 https://doi.org/10.1074/jbc.M113.521013	journal	December 2013
The FlxABCD-HdrABC proteins correspond to a novel NADH dehydrogenase/heterodisulfide reductase widespread in anaerobic bacteria and involved in ethanol metabolism in D esulfovibrio vulgaris Hildenborough : Role of FlxABCD-HdrABC in Ramos, Ana Raquel; Grein, Fabian; Oliveira, Gonçalo P. Environmental Microbiology, Vol. 17, Issue 7 https://doi.org/10.1111/1462-2920.12689	journal	January 2015
Bathocuproine-assisted reduction of copper(II) by human albumin Ivanov, A. I.; Parkinson, J. A.; Cossins, E. JBIC Journal of Biological Inorganic Chemistry, Vol. 5, Issue 1 https://doi.org/10.1007/s007750050013	journal	February 2000
Novel structure and redox chemistry of the prosthetic groups of the iron-sulfur flavoprotein sulfide dehydrogenase from Pyrococcus furiosus; evidence for a [2Fe-2S] cluster with Asp(Cys)3 ligands Hagen, W. R.; Silva, P. J.; Amorim, M. A. JBIC Journal of Biological Inorganic Chemistry, Vol. 5, Issue 4 https://doi.org/10.1007/PL00021452	journal	August 2000

Cited By (3)

Flavin-Based Electron Bifurcation, Ferredoxin, Flavodoxin, and Anaerobic Respiration With Protons (Ech) or NAD+ (Rnf) as Electron Acceptors: A Historical Review Buckel, Wolfgang; Thauer, Rudolf K. Frontiers in Microbiology, Vol. 9 https://doi.org/10.3389/fmicb.2018.00401	journal	March 2018
Electron Bifurcation and Confurcation in Methanogenesis and Reverse Methanogenesis Yan, Zhen; Ferry, James G. Frontiers in Microbiology, Vol. 9 https://doi.org/10.3389/fmicb.2018.01322	journal	June 2018
Metabolic Hydrogen Flows in Rumen Fermentation: Principles and Possibilities of Interventions Ungerfeld, Emilio M. Frontiers in Microbiology, Vol. 11 https://doi.org/10.3389/fmicb.2020.00589	journal	April 2020

Similar Records

The Electron Bifurcating FixABCX Protein Complex from Azotobacter vinelandii: Generation of Low-Potential Reducing Equivalents for Nitrogenase Catalysis

Journal Article · Thu Jul 13 00:00:00 EDT 2017 · Biochemistry · OSTI ID:1405273

Ledbetter, Rhesa N.; Garcia Costas, Amaya M.; Lubner, Carolyn E.; +17 more

Energetic Consequences of nitrite stress in Desulfovibrio vulgarisHildenborough, inferred from global transcriptional analysis

Journal Article · Thu Nov 03 00:00:00 EST 2005 · Applied and Environmental Microbiology · OSTI ID:1405273

He, Qiang; Huang, Katherine H; He, Zhili; +6 more

Respiration is essential for aerobic growth of Zymomonas mobilis ZM4

Journal Article · Tue Dec 19 00:00:00 EST 2023 · mBio (Online) · OSTI ID:1405273

Felczak, Magdalena M.; Bernard, Matthew P.; TerAvest, Michaela A.; +1 more

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
electron bifurcation
flavin
methanogenesis
iron-sulfur cluster
energy conservation

Title: Electron Bifurcation Makes the Puzzle Pieces Fall Energetically into Place in Methanogenic Energy Conservation

Citation Formats

References (18)

Cited By (3)

Similar Records

Related Subjects