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Title: Hyperspectral imaging flow cytometer

Patent ·
OSTI ID:1404931
;

A hyperspectral imaging flow cytometer can acquire high-resolution hyperspectral images of particles, such as biological cells, flowing through a microfluidic system. The hyperspectral imaging flow cytometer can provide detailed spatial maps of multiple emitting species, cell morphology information, and state of health. An optimized system can image about 20 cells per second. The hyperspectral imaging flow cytometer enables many thousands of cells to be characterized in a single session.

Research Organization:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC04-94AL85000
Assignee:
National Technology & Engineering Solutions of Sandia, LLC
Patent Number(s):
9,797,836
Application Number:
13/769,724
OSTI ID:
1404931
Resource Relation:
Patent File Date: 2013 Feb 18
Country of Publication:
United States
Language:
English

References (17)

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Imaging multiple endogenous and exogenous fluorescent species in cells and tissues
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conference March 2005
Accurate Detection of Low Levels of Fluorescence Emission in Autofluorescent Background: Francisella-Infected Macrophage Cells journal June 2010
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In vivo hyperspectral confocal fluorescence imaging to determine pigment localization and distribution in cyanobacterial cells journal March 2008
Advanced imaging of multiple mRNAs in brain tissue using a custom hyperspectral imager and multivariate curve resolution journal February 2007

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