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Title: Electrospun fibers of poly( l -lactic acid) containing lovastatin with potential applications in drug delivery

Authors:
 [1];  [2];  [1]
  1. Department of Physics and Astronomy, Center for Nanoscopic Physics, Tufts University, Medford Massachusetts 02155
  2. Chemistry Department, Rzeszow Technical University, Rzeszow Poland
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1401905
Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
Journal of Applied Polymer Science
Additional Journal Information:
Journal Volume: 134; Journal Issue: 36; Related Information: CHORUS Timestamp: 2017-10-20 18:04:01; Journal ID: ISSN 0021-8995
Publisher:
Wiley Blackwell (John Wiley & Sons)
Country of Publication:
United States
Language:
English

Citation Formats

Zhu, Yazhe, Pyda, Marek, and Cebe, Peggy. Electrospun fibers of poly( l -lactic acid) containing lovastatin with potential applications in drug delivery. United States: N. p., 2017. Web. doi:10.1002/app.45287.
Zhu, Yazhe, Pyda, Marek, & Cebe, Peggy. Electrospun fibers of poly( l -lactic acid) containing lovastatin with potential applications in drug delivery. United States. doi:10.1002/app.45287.
Zhu, Yazhe, Pyda, Marek, and Cebe, Peggy. 2017. "Electrospun fibers of poly( l -lactic acid) containing lovastatin with potential applications in drug delivery". United States. doi:10.1002/app.45287.
@article{osti_1401905,
title = {Electrospun fibers of poly( l -lactic acid) containing lovastatin with potential applications in drug delivery},
author = {Zhu, Yazhe and Pyda, Marek and Cebe, Peggy},
abstractNote = {},
doi = {10.1002/app.45287},
journal = {Journal of Applied Polymer Science},
number = 36,
volume = 134,
place = {United States},
year = 2017,
month = 5
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on May 23, 2018
Publisher's Accepted Manuscript

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  • Advanced biomaterials should also be bioactive with regard to desirable cellular responses, such as selective protein adsorption and cell attachment, proliferation, and differentiation. To enhance cell-material interactions, surface modifications have commonly been performed. Among the various surface modification approaches, atmospheric pressure glow discharge plasma has been used to change a hydrophobic polymer surface to a hydrophilic surface. Poly(L-lactic acid) (PLLA)-derived scaffolds lack cell recognition signals and the hydrophobic nature of PLLA hinders cell seeding. To make PLLA surfaces more conducive to cell attachment and spreading, surface modifications may be used to create cell-biomaterial interfaces that elicit controlled cell adhesion andmore » maintain differentiated phenotypes. In this study, (He) gaseous atmospheric plasma glow discharge was used to change the characteristics of a 3D-type polymeric scaffold from hydrophobic to hydrophilic on both the outer and inner surfaces of the scaffold and the penetration efficiency with fibronectin was investigated. Field-emission scanning electron microscope images showed that some grooves were formed on the PLLA fibers after plasma treatment. X-ray photoelectron spectroscopy data also showed chemical changes in the PLLA structure. After plasma treatment, -CN (285.76 eV) was increased in C1s and -NH{sub 2} (399.70 eV) was increased significantly and –N=CH (400.80 eV) and –NH{sub 3}{sup +} (402.05 eV) were newly appeared in N1s. These changes allowed fibronectin to penetrate into the PLLA scaffold; this could be observed by confocal microscopy. In conclusion, helium atmospheric pressure plasma treatment was effective in modifying the polymeric scaffold, making it hydrophilic, and this treatment can also be used in tissue engineering research as needed to make polymers hydrophilic.« less
  • Biodegradable polymer-based nanoparticles have been widely studied to deliver therapeutic agents to the brain after intranasal administration. However, knowledge as to the side effects of nanoparticle delivery system to the brain is limited. The aim of this study was to investigate the in vivo toxicity and immunogenicity of wheat germ agglutinin (WGA) conjugated poly(ethylene glycol)-poly(lactic acid) nanoparticles (WGA-NP) after intranasal instillation. Sprague-Dawley rats were intranasally given WGA-NP for 7 continuous days. Amino acid neurotransmitters, lactate dehydrogenase (LDH) activity, reduced glutathione (GSH), acetylcholine, acetylcholinesterase activity, tumor necrosis factor {alpha} (TNF-{alpha}) and interleukin-8 (IL-8) in rat olfactory bulb (OB) and brain weremore » measured to estimate the in vivo toxicity of WGA-NP. Balb/C mice were intranasally immunized by WGA-NP and then WGA-specific antibodies in serum and nasal wash were detected by indirect ELISA. WGA-NP showed slight toxicity to brain tissue, as evidenced by increased glutamate level in rat brain and enhanced LDH activity in rat OB. No significant changes in acetylcholine level, acetylcholinesterase activity, GSH level, TNF-{alpha} level and IL-8 level were observed in rat OB and brain for the WGA-NP group. WGA-specific antibodies in mice serum and nasal wash were not increased after two intranasal immunizations of WGA-NP. These results demonstrate that WGA-NP is a safe carrier system for intranasal delivery of therapeutic agents to the brain.« less
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  • No abstract prepared.