Electrospun fibers of poly( l ‐lactic acid) containing lovastatin with potential applications in drug delivery

Zhu, Yazhe; Pyda, Marek; Cebe, Peggy

doi:10.1002/app.45287

Title: Electrospun fibers of poly( l ‐lactic acid) containing lovastatin with potential applications in drug delivery

Journal Article · Tue May 23 00:00:00 EDT 2017 · Journal of Applied Polymer Science

DOI:https://doi.org/10.1002/app.45287· OSTI ID:1401905

Zhu, Yazhe ^[1]; Pyda, Marek ^[2]; Cebe, Peggy ^[1]

Department of Physics and Astronomy Center for Nanoscopic Physics, Tufts University Medford Massachusetts 02155
Chemistry Department Rzeszow Technical University Rzeszow Poland

ABSTRACT Lovastatin (Merck's Mevacor) is a statin drug designed to lower cholesterol, and reduce the risk of heart attack and stroke. We use electrospinning to combine the biomedical properties of lovastatin with the advantages of electrospun fibers to prepare a composite biomaterial for lovastatin delivery. Poly( l ‐lactic acid) (PLLA), a biodegradable and biocompatible polymer, was co‐spun with lovastatin. Incorporation of lovastatin at 5 or 10 wt % improved fiber alignment and surface smoothness, and increased fiber diameter. Influence of lovastatin on the phase structure (crystal, mobile amorphous, and rigid amorphous fractions) was investigated using scanning calorimetry and synchrotron X‐ray scattering. Addition of lovastatin resulted in increased crystallinity and reduced mobile amorphous fraction. PLLA fibers were characterized in terms of their drug release kinetics in comparison to PLLA film. High drug entrapment efficiency (ranging from 72% to 82%) and appropriate release profiles were achieved. In vitro drug release studies demonstrated that release occurred in two stages: an initial rapid release over the first day and a slower second stage of release which approached a plateau after 7 days. PLLA fibers have a higher release rate than comparable film. Electrospun biomaterial fibers of PLLA provide a promising new release strategy for delivery of lovastatin. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 45287.

View Accepted Manuscript (Publisher)

Cite

Export

Save

Sponsoring Organization:: USDOE

OSTI ID:: 1401905

Journal Information:: Journal of Applied Polymer Science, Journal Name: Journal of Applied Polymer Science Vol. 134 Journal Issue: 36; ISSN 0021-8995

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 15 works

Citation information provided by
Web of Science

References (40)

Vitamin-loaded electrospun cellulose acetate nanofiber mats as transdermal and dermal therapeutic agents of vitamin A acid and vitamin E Taepaiboon, Pattama; Rungsardthong, Uracha; Supaphol, Pitt European Journal of Pharmaceutics and Biopharmaceutics, Vol. 67, Issue 2 https://doi.org/10.1016/j.ejpb.2007.03.018	journal	September 2007
Drug-loaded electrospun mats of poly(vinyl alcohol) fibres and their release characteristics of four model drugs Taepaiboon, Pattama; Rungsardthong, Uracha; Supaphol, Pitt Nanotechnology, Vol. 17, Issue 9 https://doi.org/10.1088/0957-4484/17/9/041	journal	April 2006
Electrospun fiber mats containing shikonin and derivatives with potential biomedical applications Kontogiannopoulos, Konstantinos N.; Assimopoulou, Andreana N.; Tsivintzelis, Ioannis International Journal of Pharmaceutics, Vol. 409, Issue 1-2 https://doi.org/10.1016/j.ijpharm.2011.02.004	journal	May 2011
Thermal characterization of lovastatin in pharmaceutical formulations Yoshida, M. I.; Oliveira, M. A.; Gomes, E. C. L. Journal of Thermal Analysis and Calorimetry, Vol. 106, Issue 3 https://doi.org/10.1007/s10973-011-1510-0	journal	April 2011
Crystal structure, conformation and morphology of solution-spun poly(L-lactide) fibers Hoogsteen, W.; Postema, A. R.; Pennings, A. J. Macromolecules, Vol. 23, Issue 2 https://doi.org/10.1021/ma00204a041	journal	March 1990
Determination of cell asymmetry in temperature-modulated DSC Boller, A.; Okazaki, I.; Ishikiriyama, K. Journal of thermal analysis, Vol. 49, Issue 2 https://doi.org/10.1007/BF01996796	journal	August 1997
Tissue engineering Langer, R.; Vacanti, J. Science, Vol. 260, Issue 5110 https://doi.org/10.1126/science.8493529	journal	May 1993
Enthalpy of melting of α′- and α-crystals of poly(l-lactic acid) Righetti, Maria Cristina; Gazzano, Massimo; Di Lorenzo, Maria Laura European Polymer Journal, Vol. 70 https://doi.org/10.1016/j.eurpolymj.2015.07.024	journal	September 2015
Preparation and characterization of ibuprofen-loaded microspheres consisting of poly(3-hydroxybutyrate) and methoxy poly (ethylene glycol)-b-poly (D,L-lactide) blends or poly(3-hydroxybutyrate) and gelatin composites for controlled drug release Bidone, Juliana; Melo, Ana Paula P.; Bazzo, Giovana C. Materials Science and Engineering: C, Vol. 29, Issue 2 https://doi.org/10.1016/j.msec.2008.10.016	journal	March 2009
Reversible crystallization and the rigid–amorphous phase in semicrystalline macromolecules Wunderlich, B. Progress in Polymer Science, Vol. 28, Issue 3 https://doi.org/10.1016/S0079-6700(02)00085-0	journal	March 2003
Synthesis of PET-PLA/Drug Nanoparticles and Their Effect with Gold Nanoparticles for Controlled Drug Release in Cancer Chemotherapy Kumar, K. Sathish; Selvaraj, V.; Alagar, M. Research Letters in Nanotechnology, Vol. 2008 https://doi.org/10.1155/2008/389512	journal	January 2008
An Overview of Polylactides as Packaging Materials Auras, Rafael; Harte, Bruce; Selke, Susan Macromolecular Bioscience, Vol. 4, Issue 9 https://doi.org/10.1002/mabi.200400043	journal	September 2004
Rigid Amorphous Fractions and Glass Transitions in Poly(oxy-2,6-dimethyl-1,4-phenylene) ^† Pak, Jeongihm; Pyda, Marek; Wunderlich, Bernhard Macromolecules, Vol. 36, Issue 2 https://doi.org/10.1021/ma021487u	journal	January 2003
Relation between PEEK semicrystalline morphology and its subglass relaxations and glass transition Jonas, Alain; Legras, Roger Macromolecules, Vol. 26, Issue 4 https://doi.org/10.1021/ma00056a036	journal	July 1993
Electrospun PEG-PLA nanofibrous membrane for sustained release of hydrophilic antibiotics Xu, Xiuling; Zhong, Wen; Zhou, Shufei Journal of Applied Polymer Science, Vol. 118, Issue 1 https://doi.org/10.1002/app.32415	journal	May 2010
Ultrafine ibuprofen-loaded polyvinylpyrrolidone fiber mats using electrospinning Yu, Deng-Guang; Zhang, Xiao-Fei; Shen, Xia-Xia Polymer International, Vol. 58, Issue 9 https://doi.org/10.1002/pi.2629	journal	September 2009
Electrospun nanofibrous materials for tissue engineering and drug delivery Cui, Wenguo; Zhou, Yue; Chang, Jiang Science and Technology of Advanced Materials, Vol. 11, Issue 1 https://doi.org/10.1088/1468-6996/11/1/014108	journal	February 2010
Degradable Polymer Microspheres for Controlled Drug Delivery Edlund, U.; Albertsson, A. -C. Degradable Aliphatic Polyesters https://doi.org/10.1007/3-540-45734-8_3	book	January 2007
The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning Xu, X.; Chen, X.; Ma, P. European Journal of Pharmaceutics and Biopharmaceutics, Vol. 70, Issue 1 https://doi.org/10.1016/j.ejpb.2008.03.010	journal	September 2008
Synthesis of composite magnetic nanoparticles Fe₃O₄ with alendronate for osteoporosis treatment Lee, Ming Song; Su, Chao-Ming; Yeh, Jih-Chao International Journal of Nanomedicine, Vol. Volume 11 https://doi.org/10.2147/IJN.S112415	journal	January 2016
The effect of processing variables on the morphology of electrospun nanofibers and textiles Deitzel, J. M.; Kleinmeyer, J.; Harris, D. Polymer, Vol. 42, Issue 1 https://doi.org/10.1016/S0032-3861(00)00250-0	journal	January 2001
Functionality in Electrospun Nanofibrous Membranes Based on Fiber’s Size, Surface Area, and Molecular Orientation Matsumoto, Hidetoshi; Tanioka, Akihiko Membranes, Vol. 1, Issue 3 https://doi.org/10.3390/membranes1030249	journal	August 2011
Poly(lactides) co-electrospun with carbon nanotubes: thermal and cell culture properties Zhu, Yazhe; Li, Chunmei; Cebe, Peggy European Polymer Journal, Vol. 75 https://doi.org/10.1016/j.eurpolymj.2016.01.014	journal	February 2016
Poly(lactic-co-glycolic acid) electrospun fibrous meshes for the controlled release of retinoic acid Puppi, Dario; Piras, Anna Maria; Detta, Nicola Acta Biomaterialia, Vol. 6, Issue 4 https://doi.org/10.1016/j.actbio.2009.08.015	journal	April 2010
Ampicillin-Ester Bonded Branched Polymers: Characterization, Cyto-, Genotoxicity and Controlled Drug-Release Behaviour Oledzka, Ewa; Sobczak, Marcin; Nalecz-Jawecki, Grzegorz Molecules, Vol. 19, Issue 6 https://doi.org/10.3390/molecules19067543	journal	June 2014
Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend Kenawy, El-Refaie; Bowlin, Gary L.; Mansfield, Kevin Journal of Controlled Release, Vol. 81, Issue 1-2 https://doi.org/10.1016/S0168-3659(02)00041-X	journal	May 2002
Nondegradative microextrusion of resorbable polyesters for pharmaceutical and biomedical applications: The cases of poly-lactic-acid and poly-caprolactone Perale, G.; Pertici, G.; Giordano, C. Journal of Applied Polymer Science, Vol. 108, Issue 3 https://doi.org/10.1002/app.27875	journal	January 2008
Heat capacity of poly(lactic acid) Pyda, M.; Bopp, R. C.; Wunderlich, B. The Journal of Chemical Thermodynamics, Vol. 36, Issue 9 https://doi.org/10.1016/j.jct.2004.05.003	journal	September 2004
Thermodynamic and structural properties of copolymers of ethylene Alamo, Rufina; Domszy, Roman; Mandelkern, Leo The Journal of Physical Chemistry, Vol. 88, Issue 26 https://doi.org/10.1021/j150670a022	journal	December 1984
The link between rigid amorphous fraction and crystal perfection in cold-crystallized poly(ethylene terephthalate) Androsch, R.; Wunderlich, B. Polymer, Vol. 46, Issue 26 https://doi.org/10.1016/j.polymer.2005.10.099	journal	December 2005
Biodegradable polylactide/poly(ethylene glycol)/polylactide triblock copolymer micelles as anticancer drug carriers Liu, Li; Li, Chenxi; Li, Xuechen Journal of Applied Polymer Science, Vol. 80, Issue 11 https://doi.org/10.1002/app.1295	journal	January 2001
Electrospun cellulose acetate fiber mats containing curcumin and release characteristic of the herbal substance Suwantong, Orawan; Opanasopit, Praneet; Ruktanonchai, Uracha Polymer, Vol. 48, Issue 26 https://doi.org/10.1016/j.polymer.2007.11.019	journal	December 2007
Glass transition of poly(oxymethylene) Suzuki, Hidematsu; Grebowicz, Janusz; Wunderlich, Bernhard British Polymer Journal, Vol. 17, Issue 1 https://doi.org/10.1002/pi.4980170101	journal	March 1985
Heat capacity hysteresis of semicrystalline macromolecular glasses Menczel, J.; Wunderlich, B. Journal of Polymer Science: Polymer Letters Edition, Vol. 19, Issue 5 https://doi.org/10.1002/pol.1981.130190506	journal	May 1981
Electrospinning: Applications in drug delivery and tissue engineering Sill, Travis J.; von Recum, Horst A. Biomaterials, Vol. 29, Issue 13, p. 1989-2006 https://doi.org/10.1016/j.biomaterials.2008.01.011	journal	May 2008
Polymorphic Transition in Disordered Poly( l -lactide) Crystals Induced by Annealing at Elevated Temperatures Pan, Pengju; Zhu, Bo; Kai, Weihua Macromolecules, Vol. 41, Issue 12 https://doi.org/10.1021/ma800343g	journal	June 2008
A review on polymer nanofibers by electrospinning and their applications in nanocomposites Huang, Zheng-Ming; Zhang, Y.-Z.; Kotaki, M. Composites Science and Technology, Vol. 63, Issue 15, p. 2223-2253 https://doi.org/10.1016/S0266-3538(03)00178-7	journal	November 2003
Phase structure of electrospun poly(trimethylene terephthalate) composite nanofibers containing carbon nanotubes Ma, Qian; Cebe, Peggy Journal of Thermal Analysis and Calorimetry, Vol. 102, Issue 2 https://doi.org/10.1007/s10973-010-0977-4	journal	August 2010
Preclinical evaluation of lovastatin MacDonald, James S.; Gerson, Ronald J.; Kornbrust, Douglas J. The American Journal of Cardiology, Vol. 62, Issue 15 https://doi.org/10.1016/0002-9149(88)90003-3	journal	November 1988
Discovery, biochemistry and biology of lovastatin Alberts, Alfred W. The American Journal of Cardiology, Vol. 62, Issue 15 https://doi.org/10.1016/0002-9149(88)90002-1	journal	November 1988

Similar Records

Optimization of protein cross-linking in bicomponent electrospun scaffolds for therapeutic use

Journal Article · Thu Dec 17 00:00:00 EST 2015 · AIP Conference Proceedings · OSTI ID:1401905

Papa, Antonio; Guarino, Vincenzo; Cirillo, Valentina; +2 more

Phase-contrast 3D tomography of HeLa cells grown in PLLA polymer electrospun scaffolds using synchrotron X-rays

Journal Article · Wed Jan 01 00:00:00 EST 2020 · Journal of Synchrotron Radiation (Online) · OSTI ID:1401905

Bhartiya, A.; Madi, K.; Disney, C. M.; +8 more

Plasma treatment induces internal surface modifications of electrospun poly(L-lactic) acid scaffold to enhance protein coating

Journal Article · Wed Aug 21 00:00:00 EDT 2013 · Journal of Applied Physics · OSTI ID:1401905

Jin Seo, Hyok; Hee Lee, Mi; Kwon, Byeong-Ju; +6 more

Title: Electrospun fibers of poly( l ‐lactic acid) containing lovastatin with potential applications in drug delivery

Citation Formats

References (40)

Similar Records

Related Subjects