Control of mechanically activated polymersome fusion: Factors affecting fusion
- Sandia National Laboratories (SNL), Albuquerque NM (United States). Center for Integrated Nanotechnologies
ABSTRACT Previously, it was found that extruded (200 nm) polymer vesicles are capable of fusion into giant polymersomes using agitation in the presence of salt. In this study, several factors contributing to this phenomenon, including the effects of (i) polymer vesicle concentration, (ii) agitation speed and duration, and (iii) variation of the salt and its concentration are investigated. To accomplish these goals dynamic light scattering is used in conjunction with fluorescence microscopy, which provides insight into vesicles above the practical limit for DLS characterization. Increasing the concentration of the polymer dramatically increases the production of giant vesicles through the increased collisions of polymersomes. Likewise, increasing the frequency of agitation increases the efficiency of fusion, although ultimately the size of vesicle that could be produced is limited due to the high shear involved. Finally, salt‐mediation of the fusion process was not limited to NaCl, but is instead a general effect facilitated by the presence of solvated ionic compounds, albeit with different salts initiating fusion at different concentrations. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015 , 53 , 297–303
- Research Organization:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Organization:
- USDOE National Nuclear Security Administration (NNSA)
- Grant/Contract Number:
- AC04-94AL85000
- OSTI ID:
- 1182985
- Alternate ID(s):
- OSTI ID: 1401363
- Report Number(s):
- SAND-2014-15541J; 533715
- Journal Information:
- Journal of Polymer Science. Part B, Polymer Physics, Vol. 53, Issue 4; ISSN 0887-6266
- Publisher:
- WileyCopyright Statement
- Country of Publication:
- United States
- Language:
- English
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