Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe

Shou, Kangquan; Qu, Chunrong; Sun, Yao; Chen, Hao; Chen, Si; Zhang, Lei; Xu, Haibo; Hong, Xuechuan; Yu, Aixi; Cheng, Zhen

doi:10.1002/adfm.201700995

Title: Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe

Journal Article · Mon Apr 24 00:00:00 EDT 2017 · Advanced Functional Materials

DOI:https://doi.org/10.1002/adfm.201700995· OSTI ID:1533019

Shou, Kangquan ^[1]; Qu, Chunrong ^[1]; Sun, Yao ^[1]; Chen, Hao ^[2]; Chen, Si ^[2]; Zhang, Lei ^[2]; Xu, Haibo ^[3]; Hong, Xuechuan ^[3]; Yu, Aixi ^[3]; Cheng, Zhen ^[2]

Wuhan Univ. (China); Stanford Univ., CA (United States)
Stanford Univ., CA (United States)
Wuhan Univ. (China)

Contrasted with imaging in the visible (400–650 nm) and near-infrared window I (NIR-I, 650–900 nm) regions, imaging in near-infrared window II (NIR-II, 1000–1700 nm) is a highly promising in vivo imaging modality with improved resolution and deeper tissue penetration. Here, a small molecule NIR-II dye,5,5'-(1H,5H-benzo[1,2-c:4,5-c'] bis[1,2,5]thiadiazole)-4,8-diyl)bis(N,N-bis(4-(3-((tert-butyldimethylsilyl)oxy)propyl)phenyl) thiophen-2-amine), is successfully encapsulated into phospholipid vesicles to prepare a probe CQS1000. The novel NIR-II probe is studied for in vivo multifunctional biological imaging. The results of this study indicate that the NIR-II vesicle CQS1000 can noninvasively and dynamically visualize and monitor many physiological and pathological conditions of circulatory systems, including lymphatic drainage and routing, angiogenesis of tumor, and vascular deformity such as arterial thrombus formation and ischemia with high spatial and temporal resolution. More importantly, by virtue of the favorable half-life of blood circulation of CQS1000, NIR-II imaging is capable of aiding precise resection of tumor such as osteosarcoma and accelerating the process of lymph node dissection to complete sentinel lymph node biopsy for better decision making during the tumor surgery. Overall, CQS1000 is a highly promising NIR-II probe for multifunctional biomedical imaging in physiological and pathological conditions, surpassing traditional NIR-I imaging modality and pathologic assessments for clinical diagnosis and treatment.

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Research Organization:: Stanford Univ., CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: SC0008397

OSTI ID:: 1533019

Alternate ID(s):: OSTI ID: 1400851

Journal Information:: Advanced Functional Materials, Vol. 27, Issue 23; ISSN 1616-301X

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 152 works

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