In vivo quantitative whole‐brain T 1 rho MRI of multiple sclerosis
Abstract
Background To apply quantitative whole‐brain T 1 ‐rho (T 1ρ ) and T 2 imaging to the detection and quantification of brain changes resulting from multiple sclerosis (MS). Methods Twenty‐three MS patients with clinically isolated syndrome (10) and relapsing remitting MS (13) phenotypes, compared with 24 age‐matched healthy controls were imaged at 3 Tesla. An axial T 1ρ ‐weighted three‐dimensional turbo spin echo sequence with a variable flip angle and fluid suppression was used. Spin‐lock times of 0, 20, 40, 60, 80, and 100 ms were used. Corresponding T 2 maps were also acquired. Results Whole brain white matter (WM) T 1ρ maps were elevated compared with controls ( P = 0.002). WM lesion T 1ρ and T 2 values were highly correlated (r = 0.83), but T 1ρ demonstrated 25% better contrast to noise ratio ( P < 0.001). WM lesion T 1ρ correlated with disease duration. Gray matter T 1ρ was negatively correlated with the Expanded Disability Status Scale, r = −0.45, P = 0.03. Normal appearing gray matter and cortical gray matter lesions were negatively correlated on T 1ρ , but not on T 2 (r T1ρ = −0.63, p T1ρ = 0.03; r T2 = −0.17,more »
- Authors:
-
- Department of Radiology University of Vermont College of Medicine Burlington Vermont USA
- Department of Neurological Sciences University of Vermont College of Medicine Burlington Vermont USA
- Department of Radiology University of Vermont College of Medicine Burlington Vermont USA, Philips HealthTech Cleveland Ohio USA
- Department of Radiology University of Florida Gainesville Florida USA
- Department of Neurological Sciences University of Vermont College of Medicine Burlington Vermont USA, Department of Radiology North Shore University Hospital‐Long Island Jewish New York New York USA
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1400711
- Grant/Contract Number:
- SC 0001753
- Resource Type:
- Journal Article: Publisher's Accepted Manuscript
- Journal Name:
- Journal of Magnetic Resonance Imaging
- Additional Journal Information:
- Journal Name: Journal of Magnetic Resonance Imaging Journal Volume: 42 Journal Issue: 6; Journal ID: ISSN 1053-1807
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- France
- Language:
- English
Citation Formats
Gonyea, Jay V., Watts, Richard, Applebee, Angela, Andrews, Trevor, Hipko, Scott, Nickerson, Joshua P., Thornton, Lindsay, and Filippi, Christopher G. In vivo quantitative whole‐brain T 1 rho MRI of multiple sclerosis. France: N. p., 2015.
Web. doi:10.1002/jmri.24954.
Gonyea, Jay V., Watts, Richard, Applebee, Angela, Andrews, Trevor, Hipko, Scott, Nickerson, Joshua P., Thornton, Lindsay, & Filippi, Christopher G. In vivo quantitative whole‐brain T 1 rho MRI of multiple sclerosis. France. https://doi.org/10.1002/jmri.24954
Gonyea, Jay V., Watts, Richard, Applebee, Angela, Andrews, Trevor, Hipko, Scott, Nickerson, Joshua P., Thornton, Lindsay, and Filippi, Christopher G. 2015.
"In vivo quantitative whole‐brain T 1 rho MRI of multiple sclerosis". France. https://doi.org/10.1002/jmri.24954.
@article{osti_1400711,
title = {In vivo quantitative whole‐brain T 1 rho MRI of multiple sclerosis},
author = {Gonyea, Jay V. and Watts, Richard and Applebee, Angela and Andrews, Trevor and Hipko, Scott and Nickerson, Joshua P. and Thornton, Lindsay and Filippi, Christopher G.},
abstractNote = {Background To apply quantitative whole‐brain T 1 ‐rho (T 1ρ ) and T 2 imaging to the detection and quantification of brain changes resulting from multiple sclerosis (MS). Methods Twenty‐three MS patients with clinically isolated syndrome (10) and relapsing remitting MS (13) phenotypes, compared with 24 age‐matched healthy controls were imaged at 3 Tesla. An axial T 1ρ ‐weighted three‐dimensional turbo spin echo sequence with a variable flip angle and fluid suppression was used. Spin‐lock times of 0, 20, 40, 60, 80, and 100 ms were used. Corresponding T 2 maps were also acquired. Results Whole brain white matter (WM) T 1ρ maps were elevated compared with controls ( P = 0.002). WM lesion T 1ρ and T 2 values were highly correlated (r = 0.83), but T 1ρ demonstrated 25% better contrast to noise ratio ( P < 0.001). WM lesion T 1ρ correlated with disease duration. Gray matter T 1ρ was negatively correlated with the Expanded Disability Status Scale, r = −0.45, P = 0.03. Normal appearing gray matter and cortical gray matter lesions were negatively correlated on T 1ρ , but not on T 2 (r T1ρ = −0.63, p T1ρ = 0.03; r T2 = −0.17, p T2 = 0.6). Conclusion T 1ρ MRI demonstrates enhanced lesion contrast compared with T 2 , and in some cases may provide complementary information. T 1ρ may provide a useful measure of demyelinating processes in MS. J. MAGN. RESON. IMAGING 2015;42:1623–1630.},
doi = {10.1002/jmri.24954},
url = {https://www.osti.gov/biblio/1400711},
journal = {Journal of Magnetic Resonance Imaging},
issn = {1053-1807},
number = 6,
volume = 42,
place = {France},
year = {Sat May 30 00:00:00 EDT 2015},
month = {Sat May 30 00:00:00 EDT 2015}
}
Web of Science
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