skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: In vivo quantitative whole‐brain T 1 rho MRI of multiple sclerosis

Abstract

Background To apply quantitative whole‐brain T 1 ‐rho (T ) and T 2 imaging to the detection and quantification of brain changes resulting from multiple sclerosis (MS). Methods Twenty‐three MS patients with clinically isolated syndrome (10) and relapsing remitting MS (13) phenotypes, compared with 24 age‐matched healthy controls were imaged at 3 Tesla. An axial T ‐weighted three‐dimensional turbo spin echo sequence with a variable flip angle and fluid suppression was used. Spin‐lock times of 0, 20, 40, 60, 80, and 100 ms were used. Corresponding T 2 maps were also acquired. Results Whole brain white matter (WM) T maps were elevated compared with controls ( P = 0.002). WM lesion T and T 2 values were highly correlated (r = 0.83), but T demonstrated 25% better contrast to noise ratio ( P < 0.001). WM lesion T correlated with disease duration. Gray matter T was negatively correlated with the Expanded Disability Status Scale, r = −0.45, P = 0.03. Normal appearing gray matter and cortical gray matter lesions were negatively correlated on T , but not on T 2 (r T1ρ = −0.63, p T1ρ = 0.03; r T2 = −0.17,more » p T2 = 0.6). Conclusion T MRI demonstrates enhanced lesion contrast compared with T 2 , and in some cases may provide complementary information. T may provide a useful measure of demyelinating processes in MS. J. MAGN. RESON. IMAGING 2015;42:1623–1630.« less

Authors:
 [1];  [1];  [2]; ORCiD logo [3];  [1];  [1];  [4];  [5]
  1. Department of Radiology University of Vermont College of Medicine Burlington Vermont USA
  2. Department of Neurological Sciences University of Vermont College of Medicine Burlington Vermont USA
  3. Department of Radiology University of Vermont College of Medicine Burlington Vermont USA, Philips HealthTech Cleveland Ohio USA
  4. Department of Radiology University of Florida Gainesville Florida USA
  5. Department of Neurological Sciences University of Vermont College of Medicine Burlington Vermont USA, Department of Radiology North Shore University Hospital‐Long Island Jewish New York New York USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1400711
Grant/Contract Number:  
SC 0001753
Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
Journal of Magnetic Resonance Imaging
Additional Journal Information:
Journal Name: Journal of Magnetic Resonance Imaging Journal Volume: 42 Journal Issue: 6; Journal ID: ISSN 1053-1807
Publisher:
Wiley Blackwell (John Wiley & Sons)
Country of Publication:
France
Language:
English

Citation Formats

Gonyea, Jay V., Watts, Richard, Applebee, Angela, Andrews, Trevor, Hipko, Scott, Nickerson, Joshua P., Thornton, Lindsay, and Filippi, Christopher G. In vivo quantitative whole‐brain T 1 rho MRI of multiple sclerosis. France: N. p., 2015. Web. doi:10.1002/jmri.24954.
Gonyea, Jay V., Watts, Richard, Applebee, Angela, Andrews, Trevor, Hipko, Scott, Nickerson, Joshua P., Thornton, Lindsay, & Filippi, Christopher G. In vivo quantitative whole‐brain T 1 rho MRI of multiple sclerosis. France. https://doi.org/10.1002/jmri.24954
Gonyea, Jay V., Watts, Richard, Applebee, Angela, Andrews, Trevor, Hipko, Scott, Nickerson, Joshua P., Thornton, Lindsay, and Filippi, Christopher G. 2015. "In vivo quantitative whole‐brain T 1 rho MRI of multiple sclerosis". France. https://doi.org/10.1002/jmri.24954.
@article{osti_1400711,
title = {In vivo quantitative whole‐brain T 1 rho MRI of multiple sclerosis},
author = {Gonyea, Jay V. and Watts, Richard and Applebee, Angela and Andrews, Trevor and Hipko, Scott and Nickerson, Joshua P. and Thornton, Lindsay and Filippi, Christopher G.},
abstractNote = {Background To apply quantitative whole‐brain T 1 ‐rho (T 1ρ ) and T 2 imaging to the detection and quantification of brain changes resulting from multiple sclerosis (MS). Methods Twenty‐three MS patients with clinically isolated syndrome (10) and relapsing remitting MS (13) phenotypes, compared with 24 age‐matched healthy controls were imaged at 3 Tesla. An axial T 1ρ ‐weighted three‐dimensional turbo spin echo sequence with a variable flip angle and fluid suppression was used. Spin‐lock times of 0, 20, 40, 60, 80, and 100 ms were used. Corresponding T 2 maps were also acquired. Results Whole brain white matter (WM) T 1ρ maps were elevated compared with controls ( P = 0.002). WM lesion T 1ρ and T 2 values were highly correlated (r = 0.83), but T 1ρ demonstrated 25% better contrast to noise ratio ( P < 0.001). WM lesion T 1ρ correlated with disease duration. Gray matter T 1ρ was negatively correlated with the Expanded Disability Status Scale, r = −0.45, P = 0.03. Normal appearing gray matter and cortical gray matter lesions were negatively correlated on T 1ρ , but not on T 2 (r T1ρ = −0.63, p T1ρ = 0.03; r T2 = −0.17, p T2 = 0.6). Conclusion T 1ρ MRI demonstrates enhanced lesion contrast compared with T 2 , and in some cases may provide complementary information. T 1ρ may provide a useful measure of demyelinating processes in MS. J. MAGN. RESON. IMAGING 2015;42:1623–1630.},
doi = {10.1002/jmri.24954},
url = {https://www.osti.gov/biblio/1400711}, journal = {Journal of Magnetic Resonance Imaging},
issn = {1053-1807},
number = 6,
volume = 42,
place = {France},
year = {Sat May 30 00:00:00 EDT 2015},
month = {Sat May 30 00:00:00 EDT 2015}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at https://doi.org/10.1002/jmri.24954

Citation Metrics:
Cited by: 18 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

T1ρ MRI of Alzheimer's disease
journal, July 2008


Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria
journal, February 2011


Heterogeneity of Cortical Lesions in Multiple Sclerosis: An MRI Perfusion Study
journal, December 2012


Reproducibility of quantitative tractography methods applied to cerebral white matter
journal, July 2007


Commentary and Opinion: II. Statistical Parametric Mapping: Ontology and Current Issues
journal, May 1995


In vivo measurement of T1? dispersion in the human brain at 1.5 tesla
journal, January 2004


Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis
journal, June 2014


Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis
journal, January 2001


In vivo whole-brain T1-rho mapping across adulthood: Normative values and age dependence: Whole-Brain T1-rho Mapping
journal, November 2013


In vivo measurement of plaque burden in a mouse model of Alzheimer's disease
journal, January 2006


T1rho MRI of menisci and cartilage in patients with osteoarthritis at 3T
journal, September 2012


Artifacts in T1ρ-weighted imaging: Compensation for B1 and B0 field imperfections
journal, May 2007


Quantification of Perfusion and Permeability in Multiple Sclerosis: Dynamic Contrast-Enhanced MRI in 3D at 3T
journal, January 2012


Abnormal Endothelial Tight Junctions in Active Lesions and Normal-appearing White Matter in Multiple Sclerosis
journal, April 2002


T1ρ MRI contrast in the human brain: Modulation of the longitudinal rotating frame relaxation shutter-speed during an adiabatic RF pulse
journal, July 2006


Prediction of glycosaminoglycan content in human cartilage by age, T1ρ and T2 MRI
journal, February 2011


Magnetization transfer and adiabatic T1ρ MRI reveal abnormalities in normal-appearing white matter of subjects with multiple sclerosis
journal, December 2013


Cortical demyelination and diffuse white matter injury in multiple sclerosis
journal, October 2005


Clinically feasible MTR is sensitive to cortical demyelination in MS
journal, December 2012


T1ρ and T2ρ MRI in the evaluation of Parkinson’s disease
journal, January 2010


Estimation of the Onset Time of Cerebral Ischemia Using T and T 2 MRI in Rats
journal, October 2010


In Vivo Quantification of T1ρ in Lumbar Spine Disk Spaces at 3 T Using Parallel Transmission MRI
journal, July 2013


Myelin water imaging in multiple sclerosis: quantitative correlations with histopathology
journal, November 2006


T1ρ Imaging of Murine Brain Tumors at 4 T
journal, January 2001


Stereotaxic Display of Brain Lesions
journal, January 2000


Use of combined conventional and quantitative MRI to quantify pathology related to cognitive impairment in multiple sclerosis
journal, April 2008


Inflammatory Cortical Demyelination in Early Multiple Sclerosis
journal, December 2011


3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis
journal, July 2009


Early marker for Alzheimer's disease: Hippocampus T1rho (T ) estimation
journal, May 2009


T1rho (T1ρ) MR imaging in Alzheimer’ disease and Parkinson’s disease with and without dementia
journal, October 2010


Multi-modal quantitative MRI investigation of brain tissue neurodegeneration in multiple sclerosis
journal, January 2012