Engineering Gram Selectivity of Mixed‐Charge Gold Nanoparticles by Tuning the Balance of Surface Charges

Pillai, Pramod P.; Kowalczyk, Bartlomiej; Kandere‐Grzybowska, Kristiana; Borkowska, Magdalena; Grzybowski, Bartosz A.

doi:10.1002/ange.201602965

Title: Engineering Gram Selectivity of Mixed‐Charge Gold Nanoparticles by Tuning the Balance of Surface Charges

Journal Article · Thu Jun 02 00:00:00 EDT 2016 · Angewandte Chemie

DOI:https://doi.org/10.1002/ange.201602965· OSTI ID:1400458

Pillai, Pramod P. ^[1]; Kowalczyk, Bartlomiej ^[2]; Kandere‐Grzybowska, Kristiana ^[3]; Borkowska, Magdalena ^[3]; Grzybowski, Bartosz A. ^[3]

Department of Chemistry and Department of Chemical and Biological Engineering Northwestern University 2145 Sheridan Road Evanston IL 60208 USA, Department of Chemistry Indian Institute of Science Education and Research (IISER) Pune Dr. Homi Bhabha Road Pune 411008 India
Department of Chemistry and Department of Chemical and Biological Engineering Northwestern University 2145 Sheridan Road Evanston IL 60208 USA
IBS Center for Soft and Living Matter and Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan South Korea

Abstract Nanoparticles covered with ligand shells comprising both positively and negatively charged ligands exhibit Gram‐selective antibacterial action controlled by a single experimental parameter, namely the proportion of [+] and [−] ligands tethered onto these particles. Gram selectivity is attributed to the interplay between polyvalent electrostatic and non‐covalent interactions that work in unison to disrupt the bacterial cell wall. The [+/−] nanoparticles are effective in low doses, are non‐toxic to mammalian cells, and are tolerated well in mice. These results constitute the first example of rational engineering of Gram selectivity at the (macro)molecular level.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0000989

OSTI ID:: 1400458

Journal Information:: Angewandte Chemie, Journal Name: Angewandte Chemie Vol. 128 Journal Issue: 30; ISSN 0044-8249

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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