Extraction of 211At from nitric acid solutions into various organic solvents for use as an α-source for radiation chemistry studies

Ekberg, Christian; Jensen, Holger; Mezyk, Stephen P.; Mincher, Bruce J.; Skarnemark, Gunnar

doi:10.1007/s10967-017-5364-1

Title: Extraction of ²¹¹At from nitric acid solutions into various organic solvents for use as an α-source for radiation chemistry studies

Journal Article · Fri Jul 21 00:00:00 EDT 2017 · Journal of Radioanalytical and Nuclear Chemistry

DOI:https://doi.org/10.1007/s10967-017-5364-1· OSTI ID:1400268

Ekberg, Christian ^[1]; Jensen, Holger ^[2]; Mezyk, Stephen P. ^[3];

^[4]; Skarnemark, Gunnar ^[1]

Chalmers Univ. of Technology, Gothenburg (Sweden). Nuclear Chemistry and Industrial Materials Recycling
Rigshospitalet, Copenhagen (Denmark). The PET Centre
California State Univ., Long Beach, CA (United States). Dept. of Chemistry and Biochemistry
Idaho National Lab. (INL), Idaho Falls, ID (United States). Aqueous Separations and Radiochemistry Dept.

The partitioning of ²¹¹At from an irradiated bismuth target using solvent extraction into several organic solvents is presented. Although astatine speciation is difficult to measure given its invariably low chemical concentration its extraction here is consistent with the existence of a cationic species in nitric acid that is not reduced upon contact with the organic phase. This is consistent with previous work that postulated the most probable species in acidic solution as AtO⁺. The technique presented here has a simple experimental set up and provides high specific activity astatine solutions compatible for use in α-radiolysis studies.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Idaho National Laboratory (INL), Idaho Falls, ID (United States)

Sponsoring Organization:: USDOE Office of Nuclear Energy (NE), Fuel Cycle Technologies (NE-5)

Grant/Contract Number:: AC07-05ID14517

OSTI ID:: 1400268

Report Number(s):: INL/JOU-16-40093; PII: 5364

Journal Information:: Journal of Radioanalytical and Nuclear Chemistry, Vol. 314, Issue 1; ISSN 0236-5731

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 8 works

Citation information provided by
Web of Science

References (25)

Wet harvesting of no-carrier-added 211At from an irradiated 209Bi target for radiopharmaceutical applications Yordanov, A. T.; Pozzi, O.; Carlin, S. Journal of Radioanalytical and Nuclear Chemistry, Vol. 262, Issue 3 https://doi.org/10.1007/s10967-004-0481-z	journal	January 2004
SOLVENT EXTRACTION STUDIES OF INTERHALOGEN COMPOUNDS OF ASTATINE ¹ Appelman, Evan H. The Journal of Physical Chemistry, Vol. 65, Issue 2 https://doi.org/10.1021/j100820a035	journal	February 1961
Reactivity and Selectivity of the Astatine Interhalogen Compounds AtCI and AtBr Towards Simple Aromatic Substrates Meyer, G. -J.; RÖSsler, K.; StÖCklin, G. Radiochimica Acta, Vol. 24, Issue 2-3 https://doi.org/10.1524/ract.1977.24.23.81	journal	January 1977
Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine Balkin, Ethan; Hamlin, Donald; Gagnon, Katherine Applied Sciences, Vol. 3, Issue 3 https://doi.org/10.3390/app3030636	journal	September 2013
Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn–211At generator Maeda, E.; Yokoyama, A.; Taniguchi, T. Journal of Radioanalytical and Nuclear Chemistry, Vol. 303, Issue 2 https://doi.org/10.1007/s10967-014-3586-z	journal	September 2014
Design and evaluation of an external high-current target for production of ²¹¹ At Gagnon, K.; Risler, R.; Pal, S. Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 55, Issue 12 https://doi.org/10.1002/jlcr.2968	journal	October 2012
Extraction of Nitric Acid into Alcohol: Kerosene Mixtures Geist, Andreas Solvent Extraction and Ion Exchange, Vol. 28, Issue 5 https://doi.org/10.1080/07366299.2010.499286	journal	August 2010
Rapid continuous separation procedures for zirconium, niobium, technetium, bromine and iodine from complex reaction product mixtures Brodén, K.; Skarnemark, G.; Björnstad, T. Journal of Inorganic and Nuclear Chemistry, Vol. 43, Issue 4 https://doi.org/10.1016/0022-1902(81)80219-9	journal	January 1981
Some microdosmetric data on Astatine-211 Ünak, Turan Applied Radiation and Isotopes, Vol. 58, Issue 1 https://doi.org/10.1016/S0969-8043(02)00260-9	journal	January 2003
Alpha and gamma radiolysis of nuclear solvent extraction ligands used for An(III) and Ln(III) separations Mezyk, Stephen P.; Mincher, Bruce J.; Ekberg, Christian Journal of Radioanalytical and Nuclear Chemistry, Vol. 296, Issue 2 https://doi.org/10.1007/s10967-012-2036-z	journal	August 2012
Separation of astatine-211 from bismuth metal Neirinckx, R. D.; Smit, J. A. Analytica Chimica Acta, Vol. 63, Issue 1 https://doi.org/10.1016/S0003-2670(01)82189-9	journal	January 1973
Using 211At as internal alpha radiolysis source allowing for simple detection of radiolysis products Ekberg, C.; Aneheim, E.; Fermvik, A. Radiation Physics and Chemistry, Vol. 79, Issue 4 https://doi.org/10.1016/j.radphyschem.2009.10.003	journal	April 2010
Astatine-211: Its possible applications in cancer therapy Brown, I. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 37, Issue 8 https://doi.org/10.1016/0883-2889(86)90273-X	journal	January 1986
Dry-distillation of astatine-211 from irradiated bismuth targets: a time-saving procedure with high recovery yields Lindegren, Sture; Bäck, Tom; Jensen, Holger J. Applied Radiation and Isotopes, Vol. 55, Issue 2 https://doi.org/10.1016/S0969-8043(01)00044-6	journal	August 2001
Targeted alpha therapy using short-lived alpha-particles and the promise of nanobodies as targeting vehicle Dekempeneer, Yana; Keyaerts, Marleen; Krasniqi, Ahmet Expert Opinion on Biological Therapy, Vol. 16, Issue 8 https://doi.org/10.1080/14712598.2016.1185412	journal	May 2016
Astatine Standard Redox Potentials and Speciation in Acidic Medium Champion, J.; Alliot, C.; Renault, E. The Journal of Physical Chemistry A, Vol. 114, Issue 1 https://doi.org/10.1021/jp9077008	journal	January 2010
Detonability of the System Nitrobenzene, Nitric Acid, and Water. Mason, C. M.; Van Dolah, R. W.; Ribovich, John Journal of Chemical & Engineering Data, Vol. 10, Issue 2 https://doi.org/10.1021/je60025a033	journal	April 1965
Tumor Immunotargeting Using Innovative Radionuclides Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline International Journal of Molecular Sciences, Vol. 16, Issue 2 https://doi.org/10.3390/ijms16023932	journal	February 2015
Nuclear Data Sheets for A = 211 Singh, Balraj; Abriola, Daniel; Baglin, Coral Nuclear Data Sheets, Vol. 114, Issue 6-7 https://doi.org/10.1016/j.nds.2013.05.001	journal	June 2013
Extraction of astatine-211 in diisopropylether (DIPE) Alliot, Cyrille; Chérel, Michel; Barbet, Jacques Radiochimica Acta, Vol. 97, Issue 3 https://doi.org/10.1524/ract.2009.1590	journal	January 2009
Astatine Nefedov, V. D.; Norseev, Yu V.; Toropova, M. A. Russian Chemical Reviews, Vol. 37, Issue 2 https://doi.org/10.1070/RC1968v037n02ABEH001603	journal	February 1968
Review Article: The Effects of Radiation Chemistry on Solvent Extraction: 1. Conditions in Acidic Solution and a Review of TBP Radiolysis Mincher, Bruce J.; Modolo, Giuseppe; Mezyk, Stephen P. Solvent Extraction and Ion Exchange, Vol. 27, Issue 1 https://doi.org/10.1080/07366290802544767	journal	January 2009
Astatine-211: Production and Availability R. Zalutsky, Michael; Pruszynski, Marek Current Radiopharmaceuticalse, Vol. 4, Issue 3 https://doi.org/10.2174/1874471011104030177	journal	July 2011
Investigation of Astatine(III) Hydrolyzed Species: Experiments and Relativistic Calculations Champion, Julie; Sabatié-Gogova, Andréa; Bassal, Fadel The Journal of Physical Chemistry A, Vol. 117, Issue 9 https://doi.org/10.1021/jp3099413	journal	February 2013
Inorganic Astatine Chemistry Visser, Gerard W. M. Radiochimica Acta, Vol. 47, Issue 2-3 https://doi.org/10.1524/ract.1989.47.23.97	journal	January 1989

Cited By (2)

Investigation of a tellurium-packed column for isolation of astatine-211 from irradiated bismuth targets and demonstration of a semi-automated system Li, Yawen; Hamlin, Donald K.; Chyan, Ming-Kuan Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-53385-x	journal	November 2019
Towards elucidating the radiochemistry of astatine – Behavior in chloroform Aneheim, Emma; Palm, Stig; Jensen, Holger Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-52365-5	journal	November 2019

Similar Records

Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets

Journal Article · Mon Dec 30 00:00:00 EST 2019 · Scientific Reports · OSTI ID:1400268

O’Hara, Matthew J.; Krzysko, Anthony J.; Hamlin, Donald K.; +3 more

Behavior of astatine and bismuth in non-conventional solvents: Extraction into imidazolium-based ionic liquid and methyl anthranilate with active pharmaceuticals binary mixtures from nitric acid media

Journal Article · Thu Aug 03 00:00:00 EDT 2023 · Separation and Purification Technology · OSTI ID:1400268

Tereshatov, Evgeny E.; Burns, Jonathan D.; Vonder Haar, Amy L.; +11 more

Complexation of Astatine(III) with Ketones: Roles of NO₃^– Counterion and Exploration of Possible Binding Modes

Journal Article · Sun Jul 24 00:00:00 EDT 2022 · Inorganic Chemistry · OSTI ID:1400268

Burns, Jonathan D.; Tereshatov, Evgeny E.; Zhang, Bowen; +11 more

Related Subjects

07 ISOTOPE AND RADIATION SOURCES
211At
radiation chemistry
solvent extraction
speciation

Title: Extraction of 211At from nitric acid solutions into various organic solvents for use as an α-source for radiation chemistry studies

Citation Formats

References (25)

Cited By (2)

Similar Records

Related Subjects

Title: Extraction of ²¹¹At from nitric acid solutions into various organic solvents for use as an α-source for radiation chemistry studies