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Title: Communication: Programmable self-assembly of thin-shell mesostructures

 [1];  [1]
  1. Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, USA
Publication Date:
Sponsoring Org.:
OSTI Identifier:
Grant/Contract Number:
Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
Journal of Chemical Physics
Additional Journal Information:
Journal Volume: 147; Journal Issue: 14; Related Information: CHORUS Timestamp: 2018-02-14 13:44:09; Journal ID: ISSN 0021-9606
American Institute of Physics
Country of Publication:
United States

Citation Formats

Halverson, Jonathan D., and Tkachenko, Alexei V.. Communication: Programmable self-assembly of thin-shell mesostructures. United States: N. p., 2017. Web. doi:10.1063/1.4999654.
Halverson, Jonathan D., & Tkachenko, Alexei V.. Communication: Programmable self-assembly of thin-shell mesostructures. United States. doi:10.1063/1.4999654.
Halverson, Jonathan D., and Tkachenko, Alexei V.. 2017. "Communication: Programmable self-assembly of thin-shell mesostructures". United States. doi:10.1063/1.4999654.
title = {Communication: Programmable self-assembly of thin-shell mesostructures},
author = {Halverson, Jonathan D. and Tkachenko, Alexei V.},
abstractNote = {},
doi = {10.1063/1.4999654},
journal = {Journal of Chemical Physics},
number = 14,
volume = 147,
place = {United States},
year = 2017,
month =

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on October 13, 2018
Publisher's Accepted Manuscript

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  • Here, we propose a general strategy of “sequential programmable self-assembly” that enables a bottom-up design of arbitrary multi-particle architectures on nano- and microscales. We show that a naive realization of this scheme, based on the pairwise additive interactions between particles, has fundamental limitations that lead to a relatively high error rate. This can be overcome by using cooperative interparticle binding. The cooperativity is a well known feature of many biochemical processes, responsible, e.g., for signaling and regulations in living systems. Here we propose to utilize a similar strategy for high precision self-assembly, and show that DNA-mediated interactions provide a convenientmore » platform for its implementation. In particular, we outline a specific design of a DNA-based complex which we call “DNA spider,” that acts as a smart interparticle linker and provides a built-in cooperativity of binding. We demonstrate versatility of the sequential self-assembly based on spider-functionalized particles by designing several mesostructures of increasing complexity and simulating their assembly process. This includes a number of finite and repeating structures, in particular, the so-called tetrahelix and its several derivatives. Due to its generality, this approach allows one to design and successfully self-assemble virtually any structure made of a “GEOMAG” magnetic construction toy, out of nanoparticles. According to our results, once the binding cooperativity is strong enough, the sequential self-assembly becomes essentially error-free.« less
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