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Title: Site-specific incorporation of redox active amino acids into proteins

Abstract

Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.

Inventors:
; ;
Publication Date:
Research Org.:
The Scripps Research Inst., La Jolla, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1398985
Patent Number(s):
9,783,798
Application Number:
13/344,436
Assignee:
The Scripps Research Institute CHO
DOE Contract Number:  
FG03-00ER45812
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Jan 05
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Alfonta, Lital, Schultz, Peter G., and Zhang, Zhiwen. Site-specific incorporation of redox active amino acids into proteins. United States: N. p., 2017. Web.
Alfonta, Lital, Schultz, Peter G., & Zhang, Zhiwen. Site-specific incorporation of redox active amino acids into proteins. United States.
Alfonta, Lital, Schultz, Peter G., and Zhang, Zhiwen. Tue . "Site-specific incorporation of redox active amino acids into proteins". United States. doi:. https://www.osti.gov/servlets/purl/1398985.
@article{osti_1398985,
title = {Site-specific incorporation of redox active amino acids into proteins},
author = {Alfonta, Lital and Schultz, Peter G. and Zhang, Zhiwen},
abstractNote = {Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 10 00:00:00 EDT 2017},
month = {Tue Oct 10 00:00:00 EDT 2017}
}

Patent:

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