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Title: Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop

Journal Article · · Immunity

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES); National Institutes of Health (NIH)
Grant/Contract Number:
W-31-109-Eng-38; RO1AI00790; RO1AI93278; R33AI84714; U19AI117892-02
OSTI ID:
1437314
Alternate ID(s):
OSTI ID: 1397083; OSTI ID: 1463721
Journal Information:
Immunity, Journal Name: Immunity Vol. 46 Journal Issue: 5; ISSN 1074-7613
Publisher:
Cell PressCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 61 works
Citation information provided by
Web of Science

References (66)

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans journal December 2015
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env journal June 2015
Structure and immune recognition of trimeric pre-fusion HIV-1 Env journal October 2014
Dendroscope: An interactive viewer for large phylogenetic trees journal November 2007
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 journal November 2011
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface journal September 2014
Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16 journal May 2013
Broad neutralization coverage of HIV by multiple highly potent antibodies journal September 2011
Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design journal May 2016
Potent and Broad Neutralization of HIV-1 Subtype C by Plasma Antibodies Targeting a Quaternary Epitope Including Residues in the V2 Loop journal January 2011
Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers journal May 2014
HIV-1 neutralizing antibodies: understanding nature's pathways journal June 2013
Delineating Antibody Recognition in Polyclonal Sera from Patterns of HIV-1 Isolate Neutralization journal May 2013
The Role of Antibodies in HIV Vaccines journal March 2010
Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors journal July 2011
Breadth of Human Immunodeficiency Virus-Specific Neutralizing Activity in Sera: Clustering Analysis and Association with Clinical Variables journal November 2009
Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2 journal January 2013
A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies journal September 2013
A Recombinant Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Complex Stabilized by an Intermolecular Disulfide Bond between the gp120 and gp41 Subunits Is an Antigenic Mimic of the Trimeric Virion-Associated Structure journal January 2000
Human Peripheral Blood Antibodies with Long HCDR3s Are Established Primarily at Original Recombination Using a Limited Subset of Germline Genes journal May 2012
New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency journal October 2015
Pseudovirion Particles Bearing Native HIV Envelope Trimers Facilitate a Novel Method for Generating Human Neutralizing Monoclonal Antibodies Against HIV journal January 2010
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex journal November 2014
Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design journal December 2015
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1 journal July 2010
HIV-1 Virus-Like Particles Bearing Pure Env Trimers Expose Neutralizing Epitopes but Occlude Nonneutralizing Epitopes journal February 2012
Neutralizing antibodies to HIV-1 induced by immunization journal February 2013
Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9 journal February 2013
Human Immunodeficiency Virus Type 1 env Clones from Acute and Early Subtype B Infections for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies journal July 2005
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies journal October 2015
An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability journal November 2016
Profiling the Specificity of Neutralizing Antibodies in a Large Panel of Plasmas from Patients Chronically Infected with Human Immunodeficiency Virus Type 1 Subtypes B and C journal September 2008
Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design journal April 2015
Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike journal September 2015
Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site journal May 2015
Variable Loop Glycan Dependency of the Broad and Potent HIV-1-Neutralizing Antibodies PG9 and PG16 journal August 2010
Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site journal March 2012
Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire journal August 2012
Mobility of Human Immunodeficiency Virus Type 1 Pr55Gag in Living Cells journal September 2006
Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth journal November 2016
Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G journal May 2016
Antigenic Properties of the Human Immunodeficiency Virus Envelope Glycoprotein Gp120 on Virions Bound to Target Cells journal March 2015
Enzyme Digests Eliminate Nonfunctional Env from HIV-1 Particle Surfaces, Leaving Native Env Trimers Intact and Viral Infectivity Unaffected journal April 2011
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes journal December 2015
Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies journal August 2015
Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1 journal June 2010
Iterative Stable Alignment and Clustering of 2D Transmission Electron Microscope Images journal February 2012
Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target journal September 2009
Enhanced antibody half-life improves in vivo activity journal January 2010
The Antibody Response against HIV-1 journal November 2011
Nature of Nonfunctional Envelope Proteins on the Surface of Human Immunodeficiency Virus Type 1 journal February 2006
A Native-Like SOSIP.664 Trimer Based on an HIV-1 Subtype B env Gene journal January 2015
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody journal May 2016
Topology representing network enables highly accurate classification of protein images taken by cryo electron-microscope without masking journal September 2003
Comparative analysis of human and mouse immunoglobulin variable heavy regions from IMGT/LIGM-DB with IMGT/HighV-QUEST journal January 2014
B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study journal May 2012
Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting journal January 2017
Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies journal September 2012
Designed protein G core variants fold to native-like structures: Sequence selection by ORBIT tolerates variation in backbone specification journal February 2001
Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design journal November 2015
Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies journal June 2013
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies journal March 2014
Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection journal January 2014
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors journal October 2002
Insights into the trimeric HIV-1 envelope glycoprotein structure journal February 2015