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Title: Biosensors engineered from conditionally stable ligand-binding domains

Abstract

Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.

Inventors:
; ; ; ; ; ;
Publication Date:
Research Org.:
President and Fellows of Harvard College, Cambridge, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1393435
Patent Number(s):
9,766,255
Application Number:
14/993,509
Assignee:
President and Fellows of Harvard College CHO
DOE Contract Number:  
FG02-02ER63445
Resource Type:
Patent
Resource Relation:
Patent File Date: 2016 Jan 12
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Church, George M., Feng, Justin, Mandell, Daniel J., Baker, David, Fields, Stanley, Jester, Benjamin Ward, and Tinberg, Christine Elaine. Biosensors engineered from conditionally stable ligand-binding domains. United States: N. p., 2017. Web.
Church, George M., Feng, Justin, Mandell, Daniel J., Baker, David, Fields, Stanley, Jester, Benjamin Ward, & Tinberg, Christine Elaine. Biosensors engineered from conditionally stable ligand-binding domains. United States.
Church, George M., Feng, Justin, Mandell, Daniel J., Baker, David, Fields, Stanley, Jester, Benjamin Ward, and Tinberg, Christine Elaine. Tue . "Biosensors engineered from conditionally stable ligand-binding domains". United States. doi:. https://www.osti.gov/servlets/purl/1393435.
@article{osti_1393435,
title = {Biosensors engineered from conditionally stable ligand-binding domains},
author = {Church, George M. and Feng, Justin and Mandell, Daniel J. and Baker, David and Fields, Stanley and Jester, Benjamin Ward and Tinberg, Christine Elaine},
abstractNote = {Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 19 00:00:00 EDT 2017},
month = {Tue Sep 19 00:00:00 EDT 2017}
}

Patent:

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Works referenced in this record:

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