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Title: Electrospray ionizer for mass spectrometry of aerosol particles

Abstract

A device and method are disclosed to apply ESI-based mass spectroscopy to submicrometer and nanometer scale aerosol particles. Unipolar ionization is utilized to charge the particles in order to collect them electrostatically on the tip of a tungsten rod. Subsequently, the species composing the collected particles are dissolved by making a liquid flow over the tungsten rod. This liquid with dissolved aerosol contents is formed into highly charged droplets, which release unfragmented ions for mass spectroscopy, such as time-of-flight mass spectroscopy. The device is configured to operate in a switching mode, wherein aerosol deposition occurs while solvent delivery is turned off and vice versa.

Inventors:
; ; ; ; ;
Publication Date:
Research Org.:
MSP Corporation, Shoreview, MN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1393424
Patent Number(s):
9,768,005
Application Number:
15/135,132
Assignee:
MSP Corporation CHO
DOE Contract Number:
SC0013302
Resource Type:
Patent
Resource Relation:
Patent File Date: 2016 Apr 21
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; 36 MATERIALS SCIENCE

Citation Formats

He, Siqin, Hogan, Chris, Li, Lin, Liu, Benjamin Y. H., Naqwi, Amir, and Romay, Francisco. Electrospray ionizer for mass spectrometry of aerosol particles. United States: N. p., 2017. Web.
He, Siqin, Hogan, Chris, Li, Lin, Liu, Benjamin Y. H., Naqwi, Amir, & Romay, Francisco. Electrospray ionizer for mass spectrometry of aerosol particles. United States.
He, Siqin, Hogan, Chris, Li, Lin, Liu, Benjamin Y. H., Naqwi, Amir, and Romay, Francisco. 2017. "Electrospray ionizer for mass spectrometry of aerosol particles". United States. doi:. https://www.osti.gov/servlets/purl/1393424.
@article{osti_1393424,
title = {Electrospray ionizer for mass spectrometry of aerosol particles},
author = {He, Siqin and Hogan, Chris and Li, Lin and Liu, Benjamin Y. H. and Naqwi, Amir and Romay, Francisco},
abstractNote = {A device and method are disclosed to apply ESI-based mass spectroscopy to submicrometer and nanometer scale aerosol particles. Unipolar ionization is utilized to charge the particles in order to collect them electrostatically on the tip of a tungsten rod. Subsequently, the species composing the collected particles are dissolved by making a liquid flow over the tungsten rod. This liquid with dissolved aerosol contents is formed into highly charged droplets, which release unfragmented ions for mass spectroscopy, such as time-of-flight mass spectroscopy. The device is configured to operate in a switching mode, wherein aerosol deposition occurs while solvent delivery is turned off and vice versa.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = 2017,
month = 9
}

Patent:

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  • The present invention is an interface between a capillary electrophoresis separation capillary end and an electrospray ionization mass spectrometry emitter capillary end, for transporting an analyte sample from a capillary electrophoresis separation capillary to a electrospray ionization mass spectrometry emitter capillary. The interface of the present invention has: (a) a charge transfer fitting enclosing both of the capillary electrophoresis capillary end and the electrospray ionization mass spectrometry emitter capillary end; (b) a reservoir containing an electrolyte surrounding the charge transfer fitting; and (c) an electrode immersed into the electrolyte, the electrode closing a capillary electrophoresis circuit and providing charge transfermore » across the charge transfer fitting while avoiding substantial bulk fluid transfer across the charge transfer fitting. Advantages of the present invention have been demonstrated as effective in providing high sensitivity and efficient analyses.« less
  • The present invention is an interface between a capillary electrophoresis separation capillary end and an electrospray ionization mass spectrometry emitter capillary end, for transporting an anolyte sample from a capillary electrophoresis separation capillary to a electrospray ionization mass spectrometry emitter capillary. The interface of the present invention has: (a) a charge transfer fitting enclosing both of the capillary electrophoresis capillary end and the electrospray ionization mass spectrometry emitter capillary end; (b) a reservoir containing an electrolyte surrounding the charge transfer fitting; and (c) an electrode immersed into the electrolyte, the electrode closing a capillary electrophoresis circuit and providing charge transfermore » across the charge transfer fitting while avoiding substantial bulk fluid transfer across the charge transfer fitting. Advantages of the present invention have been demonstrated as effective in providing high sensitivity and efficient analyses.« less
  • The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).
  • The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation (LA) with electrospray ionization (ESI).
  • The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).