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Title: Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges

Abstract

Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. Finally, we have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals.

Authors:
 [1];  [2];  [3]
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division
  2. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division; Univ. of California, Berkeley, CA (United States). QB3 Inst.; Joint BioEnergy Inst. (JBEI), Emeryville, CA (United States); Univ. of California, Berkeley, CA (United States). Dept. of Bioengineering; Univ. of California, Berkeley, CA (United States). Dept. of Chemical and Biomolecular Engineering; Technical Univ. of Denmark, Horsholm (Denmark). Novo Nordisk Foundation Center for Biosustainability
  3. Univ. of California, Berkeley, CA (United States). QB3 Inst.
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23); National Science Foundation (NSF)
OSTI Identifier:
1393209
DOE Contract Number:  
AC02-05CH11231; EEC-0540879; 1106400
Resource Type:
Journal Article
Journal Name:
The Journal of Antibiotics
Additional Journal Information:
Journal Volume: 70; Journal Issue: 4; Journal ID: ISSN 0021-8820
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English

Citation Formats

Yuzawa, Satoshi, Keasling, Jay D., and Katz, Leonard. Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges. United States: N. p., 2016. Web. doi:10.1038/ja.2016.136.
Yuzawa, Satoshi, Keasling, Jay D., & Katz, Leonard. Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges. United States. doi:10.1038/ja.2016.136.
Yuzawa, Satoshi, Keasling, Jay D., and Katz, Leonard. Wed . "Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges". United States. doi:10.1038/ja.2016.136.
@article{osti_1393209,
title = {Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges},
author = {Yuzawa, Satoshi and Keasling, Jay D. and Katz, Leonard},
abstractNote = {Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. Finally, we have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals.},
doi = {10.1038/ja.2016.136},
journal = {The Journal of Antibiotics},
issn = {0021-8820},
number = 4,
volume = 70,
place = {United States},
year = {2016},
month = {11}
}

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