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Title: Inhibition of HIF-2.alpha. heterodimerization with HIF1.beta. (ARNT)

Abstract

Provided is a method of inhibiting heterodimerization of HIF-2.alpha. to HIF1.beta. (ARNT) comprising binding certain small molecules to the HIF-2.alpha. PAS-B domain cavity but not to HIF1.alpha. and inhibiting HIF-2.alpha. heterodimerization to HIF1.beta. (ARNT) but not inhibiting HIF1.alpha. heterodimerization to HIF1.beta. (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2.alpha. heterodimerization inhibitors and also simply as certain small molecules.

Inventors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1390247
Patent Number(s):
9,757,379
Application Number:
14/442,485
Assignee:
The Board of Regents of the University of Texas System ANL
DOE Contract Number:
AC02-06CH11357
Resource Type:
Patent
Resource Relation:
Patent File Date: 2013 Nov 14
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Bruick, Richard K., Caldwell, Charles G., Frantz, Doug E., Gardner, Kevin H., MacMillan, John B., Scheuermann, Thomas H., and Tambar, Uttam K. Inhibition of HIF-2.alpha. heterodimerization with HIF1.beta. (ARNT). United States: N. p., 2017. Web.
Bruick, Richard K., Caldwell, Charles G., Frantz, Doug E., Gardner, Kevin H., MacMillan, John B., Scheuermann, Thomas H., & Tambar, Uttam K. Inhibition of HIF-2.alpha. heterodimerization with HIF1.beta. (ARNT). United States.
Bruick, Richard K., Caldwell, Charles G., Frantz, Doug E., Gardner, Kevin H., MacMillan, John B., Scheuermann, Thomas H., and Tambar, Uttam K. Tue . "Inhibition of HIF-2.alpha. heterodimerization with HIF1.beta. (ARNT)". United States. doi:. https://www.osti.gov/servlets/purl/1390247.
@article{osti_1390247,
title = {Inhibition of HIF-2.alpha. heterodimerization with HIF1.beta. (ARNT)},
author = {Bruick, Richard K. and Caldwell, Charles G. and Frantz, Doug E. and Gardner, Kevin H. and MacMillan, John B. and Scheuermann, Thomas H. and Tambar, Uttam K.},
abstractNote = {Provided is a method of inhibiting heterodimerization of HIF-2.alpha. to HIF1.beta. (ARNT) comprising binding certain small molecules to the HIF-2.alpha. PAS-B domain cavity but not to HIF1.alpha. and inhibiting HIF-2.alpha. heterodimerization to HIF1.beta. (ARNT) but not inhibiting HIF1.alpha. heterodimerization to HIF1.beta. (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2.alpha. heterodimerization inhibitors and also simply as certain small molecules.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 12 00:00:00 EDT 2017},
month = {Tue Sep 12 00:00:00 EDT 2017}
}

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