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Title: Compositions containing amino acids, phosphate and manganese and their uses

Abstract

The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.

Inventors:
;
Publication Date:
Research Org.:
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1390218
Patent Number(s):
9,758,760
Application Number:
14/962,596
Assignee:
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. CHO
DOE Contract Number:
FG02-04ER63918
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Dec 08
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Daly, Michael J., and Gaidamakova, Elena K. Compositions containing amino acids, phosphate and manganese and their uses. United States: N. p., 2017. Web.
Daly, Michael J., & Gaidamakova, Elena K. Compositions containing amino acids, phosphate and manganese and their uses. United States.
Daly, Michael J., and Gaidamakova, Elena K. 2017. "Compositions containing amino acids, phosphate and manganese and their uses". United States. doi:. https://www.osti.gov/servlets/purl/1390218.
@article{osti_1390218,
title = {Compositions containing amino acids, phosphate and manganese and their uses},
author = {Daly, Michael J. and Gaidamakova, Elena K.},
abstractNote = {The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = 2017,
month = 9
}

Patent:

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  • The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protectivemore » composition.« less
  • This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositionsmore » may comprise D. radiodurans extracts.« less
  • Improved gasolines contain, as a detergent additive, (alkyl polyoxyalkyl) amino alkanoic acids such as CH3-(CH2)(8-10)-CH2-(O-CH2-CH(-CH3))2-NH-(CH2)2-COOH.
  • The subject invention provides at least one nucleic acid sequence encoding an aldouronate-utilization regulon isolated from Paenibacillus sp. strain JDR-2, a bacterium which efficiently utilizes xylan and metabolizes aldouronates (methylglucuronoxylosaccharides). The subject invention also provides a means for providing a coordinately regulated process in which xylan depolymerization and product assimilation are coupled in Paenibacillus sp. strain JDR-2 to provide a favorable system for the conversion of lignocellulosic biomass to biobased products. Additionally, the nucleic acid sequences encoding the aldouronate-utilization regulon can be used to transform other bacteria to form organisms capable of producing a desired product (e.g., ethanol, 1-butanol, acetoin,more » 2,3-butanediol, 1,3-propanediol, succinate, lactate, acetate, malate or alanine) from lignocellulosic biomass.« less