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Title: TMBIM-mediated Ca 2+ homeostasis and cell death

Abstract

Ca 2+ is a ubiquitous intracellular messenger that regulates numerous physiological activities in humans, animals, plants, and bacteria. Cytosolic Ca 2+ is kept at a low level, but subcellular organelles such as the endoplasmic reticulum (ER) and Golgi Apparatus maintain high-concentration Ca 2+ stores. Under resting conditions, store Ca 2+ homeostasis is dynamically regulated to equilibrate between active Ca 2+ uptake and passive Ca 2+ leak processes. The evolutionarily conserved Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) proteins mediate Ca 2+ homeostasis and cell death. This review focuses on recent advances in functional and structural analysis of TMBIM proteins in regulation of the two related functions. The roles of TMBIM proteins in pathogen infection and cancer are also discussed with prospects for treatment.

Authors:
ORCiD logo [1]
  1. Brookhaven National Lab. (BNL), Upton, NY (United States)
Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1389232
Report Number(s):
BNL-114189-2017-JA
Journal ID: ISSN 0167-4889
Grant/Contract Number:
SC0012704
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Additional Journal Information:
Journal Name: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research; Journal Volume: 1864; Journal Issue: 6; Journal ID: ISSN 0167-4889
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Ca2+ homeostasis; Ca2+ signaling; cell death; apoptosis; Bax inhibitor-1; TMBIM; membrane proteins; cancer; cellular stress; Ca2+ channel structure.

Citation Formats

Liu, Qun. TMBIM-mediated Ca2+ homeostasis and cell death. United States: N. p., 2017. Web. doi:10.1016/j.bbamcr.2016.12.023.
Liu, Qun. TMBIM-mediated Ca2+ homeostasis and cell death. United States. doi:10.1016/j.bbamcr.2016.12.023.
Liu, Qun. Thu . "TMBIM-mediated Ca2+ homeostasis and cell death". United States. doi:10.1016/j.bbamcr.2016.12.023. https://www.osti.gov/servlets/purl/1389232.
@article{osti_1389232,
title = {TMBIM-mediated Ca2+ homeostasis and cell death},
author = {Liu, Qun},
abstractNote = {Ca2+ is a ubiquitous intracellular messenger that regulates numerous physiological activities in humans, animals, plants, and bacteria. Cytosolic Ca2+ is kept at a low level, but subcellular organelles such as the endoplasmic reticulum (ER) and Golgi Apparatus maintain high-concentration Ca2+ stores. Under resting conditions, store Ca2+ homeostasis is dynamically regulated to equilibrate between active Ca2+ uptake and passive Ca2+ leak processes. The evolutionarily conserved Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) proteins mediate Ca2+ homeostasis and cell death. This review focuses on recent advances in functional and structural analysis of TMBIM proteins in regulation of the two related functions. The roles of TMBIM proteins in pathogen infection and cancer are also discussed with prospects for treatment.},
doi = {10.1016/j.bbamcr.2016.12.023},
journal = {Biochimica et Biophysica Acta (BBA) - Molecular Cell Research},
number = 6,
volume = 1864,
place = {United States},
year = {Thu Jan 05 00:00:00 EST 2017},
month = {Thu Jan 05 00:00:00 EST 2017}
}

Journal Article:
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