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Title: Tumour exosome integrins determine organotropic metastasis

Journal Article · · Nature (London)
DOI:https://doi.org/10.1038/nature15756· OSTI ID:1378654
 [1];  [1];  [2];  [3];  [4];  [5];  [5];  [6];  [1];  [7];  [1];  [1];  [8];  [8];  [9];  [9];  [10];  [11];  [1];  [12] more »;  [1];  [13];  [1];  [14];  [14];  [14];  [15];  [16];  [17];  [18];  [19];  [20];  [21];  [21];  [3];  [22];  [22];  [22];  [22];  [23];  [24];  [25];  [26];  [27];  [28];  [11];  [29];  [30];  [31];  [32];  [1];  [33];  [34];  [35] « less
  1. Weill Cornell Medicine, New York, NY (United States). Children's Cancer and Blood Foundation Lab. Dept. of Pediatrics. Dept. of Cell and Developmental Biology. Drukier Inst. for Children's Health. Meyer Cancer Center
  2. Weill Cornell Medicine, New York, NY (United States). Children's Cancer and Blood Foundation Lab. Dept. of Pediatrics. Dept. of Cell and Developmental Biology. Drukier Inst. for Children's Health. Meyer Cancer Center; National Taiwan Univ., Taipei (Taiwan). Dept. of Plant Pathology and Microbiology. Center for Biotechnology
  3. Weill Cornell Medicine, New York, NY (United States). Children's Cancer and Blood Foundation Lab. Dept. of Pediatrics. Dept. of Cell and Developmental Biology. Drukier Inst. for Children's Health. Meyer Cancer Center; Univ. of Porto (Portugal). Abel Salazar Biomedical Sciences Inst. Graduate Program in Areas of Basic and Applied Biology
  4. Weill Cornell Medicine, New York, NY (United States). Children's Cancer and Blood Foundation Lab. Dept. of Pediatrics. Dept. of Cell and Developmental Biology. Drukier Inst. for Children's Health. Meyer Cancer Center; Univ. of Tokyo (Japan). Faculty of Medicine. Dept. of Obstetrics and Gynecology
  5. Rockefeller Univ., New York, NY (United States). Proteomics Resource Center
  6. Memorial Sloan Kettering Cancer Center, New York, NY (United States). Dept. of Pathology
  7. Karolinska Inst., Stockholm (Sweden). Dept. of Oncology and Pathology
  8. Rockefeller Univ., New York, NY (United States). Electron Microscopy Resource Center (EMRC)
  9. Memorial Sloan Kettering Cancer Center, New York, NY (United States). Breast Service. Dept. of Surgery
  10. Weill Cornell Medicine, New York, NY (United States). Children's Cancer and Blood Foundation Lab. Dept. of Pediatrics. Dept. of Cell and Developmental Biology. Drukier Inst. for Children's Health. Meyer Cancer Center; Linkoping Univ. (Sweden). Faculty of Health Sciences. Dept. of Clinical and Experimental Medicine. Dept. of Surgery
  11. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division
  12. Weill Cornell Medicine, New York, NY (United States). Genomics Resources Core Facility
  13. Weill Cornell Medicine, New York, NY (United States). Children's Cancer and Blood Foundation Lab. Dept. of Pediatrics. Dept. of Cell and Developmental Biology. Drukier Inst. for Children's Health. Meyer Cancer Center; Memorial Sloan Kettering Cancer Center, New York, NY (United States). Dept. of Surgery
  14. Memorial Sloan Kettering Cancer Center, New York, NY (United States). Dept. of Pediatrics
  15. Alberta Children's Hospital, Calgary, AB (Canada). Division of Pediatric Oncology
  16. Columbia Univ., New York, NY (United States). School of Medicine. Division of Hematology/Oncology
  17. Memorial Sloan Kettering Cancer Center, New York, NY (United States). Orthopaedic Service. Dept. of Surgery
  18. Linkoping Univ. (Sweden). Faculty of Health Sciences. Dept. of Clinical and Experimental Medicine. Dept. of Surgery
  19. Oslo Univ. Hospital (Norway). Dept. of Hepato-Pancreato-Biliary Surgery
  20. Oslo Univ. Hospital (Norway). Dept. of Cancer Genetics. Inst. for Cancer Research
  21. Univ. of Nebraska Medical Center, Omaha, NE (United States). Eppley Inst. for Research in Cancer and Allied Diseases
  22. Univ. of Nebraska Medical Center, Omaha, NE (United States). Dept. of Biochemistry and Molecular Biology
  23. Memorial Sloan Kettering Cancer Center, New York, NY (United States). Dept. of Surgery
  24. Weill Cornell Medicine, New York, NY (United States). Children's Cancer and Blood Foundation Lab. Dept. of Pediatrics. Dept. of Cell and Developmental Biology. Drukier Inst. for Children's Health. Meyer Cancer Center; Memorial Sloan Kettering Cancer Center, New York, NY (United States). Gastric and Mixed Tumor Service. Dept. of Surgery
  25. Oslo Univ. Hospital (Norway). Dept. of Tumor Biology. Norwegian Radium Hospital; Univ. of Oslo (Norway). Inst. for Clinical Medicine. Faculty of Medicine
  26. Univ. Medical Center Hamburg-Eppendorf, Hamburg (Germany). Dept. of Gynecology
  27. Univ. Medical Center Hamburg-Eppendorf, Hamburg (Germany). Dept. of Tumor Biology
  28. Univ. of Pennsylvania, Philadelphia, PA (United States). Dept. of Radiation Oncology. Abramson Family Cancer Research Inst.
  29. Univ. of Pennsylvania, Philadelphia, PA (United States). Dept. of Biochemistry and Biophysics. Perelman School of Medicine
  30. Princeton Univ., NJ (United States). Dept. of Molecular Biology; Rutgers Cancer Inst. of New Jersey, New Brunswick, NJ (United States)
  31. Memorial Sloan Kettering Cancer Center, New York, NY (United States). Breast Medicine Service. Dept. of Medicine
  32. Fred Hutchinson Cancer Research Center, Seattle, WA (United States)
  33. Weill Cornell Medicine, New York, NY (United States). Children's Cancer and Blood Foundation Lab. Dept. of Pediatrics. Dept. of Cell and Developmental Biology. Drukier Inst. for Children's Health. Meyer Cancer Center; Spanish National Cancer Research Center (CNIO), Madrid (Spain). Microenvironment and Metastasis Lab. Dept. of Molecular Oncology
  34. Memorial Sloan Kettering Cancer Center, New York, NY (United States). Dept. of Medicine; Weill Cornell Medicine, New York, NY (United States). Dept. of Medicine
  35. Weill Cornell Medicine, New York, NY (United States). Children's Cancer and Blood Foundation Lab. Dept. of Pediatrics. Dept. of Cell and Developmental Biology. Drukier Inst. for Children's Health. Meyer Cancer Center; Memorial Sloan Kettering Cancer Center, New York, NY (United States). Dept. of Pediatrics
+ Show Author Affiliations

Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one of cancer’s greatest mysteries. In this paper, we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells. We show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche. Treatment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells. Exosome proteomics revealed distinct integrin expression patterns, in which the exosomal integrins α6β4 and α6β1 were associated with lung metastasis, while exosomal integrin αvβ5 was linked to liver metastasis. Targeting the integrins α6β4 and αvβ5 decreased exosome uptake, as well as lung and liver metastasis, respectively. We demonstrate that exosome integrin uptake by resident cells activates Src phosphorylation and pro-inflammatory S100 gene expression. In conclusion, our clinical data indicate that exosomal integrins could be used to predict organ-specific metastasis.

Research Organization:
Weill Cornell Medicine, New York, NY (United States); Memorial Sloan Kettering Cancer Center, New York, NY (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE; National Inst. of Health (NIH) (United States); USDOD; Ministry of Science and Technology (Taiwan)
Grant/Contract Number:
AC02-05CH11231; P30 CA008748; U01-CA169538; R01-CA169416; W81XWH-13-10249; W81XWH-13-1-0425; 101-2918-I-002-016
OSTI ID:
1378654
Journal Information:
Nature (London), Vol. 527, Issue 7578; ISSN 0028-0836
Publisher:
Nature Publishing GroupCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 3074 works
Citation information provided by
Web of Science

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Systematic Evolution of Ligands by Exosome Enrichment: A Proof-of-Concept Study for Exosome-Based Targeting Peptide Screening journal December 2018
Exosome-Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs journal January 2018
Biomimetic strategies to recapitulate organ specific microenvironments for studying breast cancer metastasis: Biomimetic strategies to study breast cancer metastasis journal May 2017
Exosomes play roles in sequential processes of tumor metastasis journal November 2018
Tumor‐derived exosomes: Potential biomarkers and therapeutic target in the treatment of colorectal cancer journal December 2018
Leukemia‐derived exosomes and cytokines pave the way for entry into the brain journal December 2018
The innate immune architecture of lung tumors and its implication in disease progression journal February 2019
Oncogenic transformation of lung cells results in distinct exosome protein profile similar to the cell of origin journal September 2017
Protein Composition Reflects Extracellular Vesicle Heterogeneity journal January 2019
Oncogenic Regulation of Extracellular Vesicle Proteome and Heterogeneity journal January 2019
Post-translational modification and protein sorting to small extracellular vesicles including exosomes by ubiquitin and UBLs journal July 2019
Myeloid-derived suppressor cells and tumor escape from immune surveillance journal October 2016
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Organotropic drug delivery: Synthetic nanoparticles and extracellular vesicles journal April 2019
Exosomes, metastases, and the miracle of cancer stem cell markers journal April 2019
Chemotherapy-induced metastasis: mechanisms and translational opportunities journal January 2018
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MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression journal February 2017
Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer journal March 2017
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Pre-metastatic niches: organ-specific homes for metastases journal March 2017
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Dormant tumour cells, their niches and the influence of immunity journal October 2018
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The lung microenvironment: an important regulator of tumour growth and metastasis journal December 2018
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Paradoxes of tumour complexity: somatic selection, vulnerability by design, or infectious aetiology? journal December 2018
Exosomes containing ErbB2/ CRK induce vascular growth in premetastatic niches and promote metastasis of bladder cancer journal June 2019
Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery journal June 2016
Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma journal January 2017
Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies journal May 2018
Role of the HGF/c-MET tyrosine kinase inhibitors in metastasic melanoma journal February 2018
Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment journal April 2018
Mechanisms associated with biogenesis of exosomes in cancer journal March 2019
Exosomes promote pre-metastatic niche formation in ovarian cancer journal August 2019
Exosome-mimetic nanoplatforms for targeted cancer drug delivery journal July 2019
High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer journal June 2019
Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients journal May 2016
Exosomes isolated from cancer patients’ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells journal August 2017
Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma journal April 2018
Dual effect of DLBCL-derived EXOs in lymphoma to improve DC vaccine efficacy in vitro while favor tumorgenesis in vivo journal August 2018
The emerging roles of exosomes in the modulation of immune responses in cancer journal March 2018
Functional proteins of mesenchymal stem cell-derived extracellular vesicles journal November 2019
Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons journal February 2018
Extracellular Vesicles in Human Reproduction in Health and Disease journal January 2018
Role of connexin 43 in different forms of intercellular communication – gap junctions, extracellular vesicles and tunnelling nanotubes journal October 2017
Molecular mobility and activity in an intravital imaging setting – implications for cancer progression and targeting journal March 2018
Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyan clinical isolate defines a core parasite secretome journal January 2017
Induction of IFNT-Stimulated Genes by Conceptus-Derived Exosomes during the Attachment Period journal June 2016
Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes journal April 2018
Nanoplasmonic pillars engineered for single exosome detection journal August 2018
Metastatic lung disease in children with solid tumors: a historical excursion journal February 2019
Methods for the Determination of the Purity of Exosomes journal January 2020
Autologous cancer cell-derived extracellular vesicles as drug-delivery systems: a systematic review of preclinical and clinical findings and translational implications journal February 2019
Technical Advances to Study Extracellular Vesicles journal November 2017
Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases journal August 2017
The Origin and Functions of Exosomes in Cancer journal March 2018
Exosomes: A Novel Strategy for Treatment and Prevention of Diseases journal June 2017
Extracellular Vesicles in Non-Small-Cell Lung Cancer: Functional Role and Involvement in Resistance to Targeted Treatment and Immunotherapy journal December 2019
Exosomal MicroRNAs in Breast Cancer towards Diagnostic and Therapeutic Applications journal June 2017
The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition journal August 2017
Exosomes as miRNA Carriers: Formation–Function–Future journal December 2016
Ceramide Metabolism Balance, a Multifaceted Factor in Critical Steps of Breast Cancer Development
  • García-González, Victor; Díaz-Villanueva, José; Galindo-Hernández, Octavio
  • International Journal of Molecular Sciences, Vol. 19, Issue 9 https://doi.org/10.3390/ijms19092527
journal August 2018
Exosomes and the Future of Immunotherapy in Pancreatic Cancer journal January 2019
Theranostic Iron Oxide Nanoparticle Cargo Defines Extracellular Vesicle-Dependent Modulation of Macrophage Activation and Migratory Behavior journal July 2018
Designed Microdevices for In Vitro Diagnostics journal September 2017
Hypoxia Inducible Factor-1α Potentiates Jagged 1-Mediated Angiogenesis by Mesenchymal Stem Cell-Derived Exosomes journal April 2017
Extracellular vesicles can act as a potent immunomodulators of human microglial cells
  • Jonavičė, Ugnė; Tunaitis, Virginijus; Kriaučiūnaitė, Karolina
  • Journal of Tissue Engineering and Regenerative Medicine, Vol. 13, Issue 2 https://doi.org/10.1002/term.2810
journal January 2019
Pathways of production and delivery of hepatocyte exosomes journal October 2017
Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 journal June 2017
KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis journal September 2017
Nanoscale lateral displacement arrays for the separation of exosomes and colloids down to 20 nm journal August 2016
Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications journal October 2016
Bone marrow hematopoietic dysfunction in untreated chronic lymphocytic leukemia patients journal October 2018
Molecular alterations of cancer cell and tumour microenvironment in metastatic gastric cancer journal May 2018
Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG journal June 2019
Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles journal January 2018
Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis journal December 2018
Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells journal September 2019
Tumor-derived exosomes antagonize innate antiviral immunity journal January 2018
Bovine milk-derived exosomes from colostrum are enriched with proteins implicated in immune response and growth journal July 2017
Organotropism: new insights into molecular mechanisms of breast cancer metastasis journal February 2018
Extracellular vesicles as cancer liquid biopsies: from discovery, validation, to clinical application journal January 2019
Extracellular vesicles: their role in cancer biology and epithelial–mesenchymal transition journal December 2016
Exosomes participate in the carcinogenesis and the malignant behavior of gastric cancer journal January 2017
Proteomic insights into extracellular vesicle biology – defining exosomes and shed microvesicles journal November 2016
Exosomal microRNA communication between tissues during organogenesis journal September 2017
Going live with tumor exosomes and microvesicles journal January 2017
Placental Nano-vesicles Target to Specific Organs and Modulate Vascular Tone In Vivo journal October 2017
Exosomes in postshock mesenteric lymph are key mediators of acute lung injury triggering the macrophage activation via Toll‐like receptor 4 journal August 2017
Prospective exosome‐focused translational research for afatinib study of non‐small cell lung cancer patients expressing EGFR (EXTRA study) journal December 2018
Exosomes in cancer development and clinical applications journal July 2018
Extracellular vesicles from human saliva promote hemostasis by delivering coagulant tissue factor to activated platelets journal April 2018
Lipid-filled vesicles modulate macrophages journal March 2019
Extracellular Vesicles: A New Perspective in Tumor Therapy journal January 2018
Exosomes in the Oncobiology, Diagnosis, and Therapy of Hepatic Carcinoma: A New Player of an Old Game journal July 2018
Increased Extracellular Vesicles Mediate WNT5A Signaling in Idiopathic Pulmonary Fibrosis journal December 2018
Immunological and non-immunological effects of stem cell-derived extracellular vesicles on the ischaemic brain journal January 2018
Exosomal regulation of lymphocyte homing to the gut journal December 2018
Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis journal January 2019
Extracellular vesicles of carcinoma-associated fibroblasts creates a pre-metastatic niche in the lung through activating fibroblasts journal December 2019
Integrin-β5, a miR-185-targeted gene, promotes hepatocellular carcinoma tumorigenesis by regulating β-catenin stability journal January 2018
Recent advances in understanding the complexities of metastasis journal January 2018
Tumor-promoting effects of pancreatic cancer cell exosomes on THP-1-derived macrophages journal November 2018
RNA Profiles of Circulating Tumor Cells and Extracellular Vesicles for Therapy Stratification of Metastatic Breast Cancer Patients journal July 2018
“Exosomics”—A Review of Biophysics, Biology and Biochemistry of Exosomes With a Focus on Human Breast Milk journal March 2018
Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures journal June 2018
MDSCs: Key Criminals of Tumor Pre-metastatic Niche Formation journal February 2019
Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer journal August 2018
Modification of Cardiac Progenitor Cell-Derived Exosomes by miR-322 Provides Protection against Myocardial Infarction through Nox2-Dependent Angiogenesis journal January 2019
Cancer Stem Cells, Bone and Tumor Microenvironment: Key Players in Bone Metastases journal February 2018
Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types journal June 2019
Tumor-Derived Extracellular Vesicles Inhibit Natural Killer Cell Function in Pancreatic Cancer journal June 2019
Vitamin D Impacts the Expression of Runx2 Target Genes and Modulates Inflammation, Oxidative Stress and Membrane Vesicle Biogenesis Gene Networks in 143B Osteosarcoma Cells journal March 2017
Extracellular Vesicles in Hematological Malignancies: From Biology to Therapy journal June 2017
Extracellular Vesicles Enhance Multiple Myeloma Metastatic Dissemination journal July 2019
Deciphering the Molecular Profile of Lung Cancer: New Strategies for the Early Detection and Prognostic Stratification journal January 2019
High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources journal January 2016
Bone Marrow Dendritic Cells Derived Microvesicles for Combinational Immunochemotherapy against Tumor journal September 2017
Exosomes from Cardiomyocyte Progenitor Cells and Mesenchymal Stem Cells Stimulate Angiogenesis Via EMMPRIN journal August 2016
Exploiting Exosomes in Cancer Liquid Biopsies and Drug Delivery journal January 2019
Embryonic Stem Cells‐Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy journal February 2019
Cholangiocyte‐Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis journal May 2019
Newly developed anti‐S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis journal December 2018
Development and validation of serum exosomal microRNAs as diagnostic and prognostic biomarkers for hepatocellular carcinoma journal September 2018
The critical role of exosomes in tumor biology journal October 2018
Extraction and Analysis of Extracellular Vesicle-Associated miRNAs Following Antibody-Based Extracellular Vesicle Capture from Plasma Samples book August 2017
Mining Exosomal MicroRNAs from Human-Induced Pluripotent Stem Cells-Derived Cardiomyocytes for Cardiac Regeneration book February 2018
Function of extracellular vesicle-associated miRNAs in metastasis journal June 2016
The emerging clinical potential of circulating extracellular vesicles for non-invasive glioma diagnosis and disease monitoring journal March 2019
The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies journal August 2018
The Relationship between Exosomes and Cancer: Implications for Diagnostics and Therapeutics journal February 2019
Shedding light on the cell biology of extracellular vesicles journal January 2018
Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer journal January 2018
Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells journal April 2019
Differential Proteomic Analysis of Human Saliva using Tandem Mass Tags Quantification for Gastric Cancer Detection journal February 2016
Exosomal microRNA miR-1246 induces cell motility and invasion through the regulation of DENND2D in oral squamous cell carcinoma journal December 2016
Extracellular vesicles and viruses: Are they close relatives? journal July 2016
Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane journal September 2017
Microfluidics-based on-a-chip systems for isolating and analysing extracellular vesicles journal August 2018
Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via the transfer of microRNA-125b journal April 2019
Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAFV600E mutation journal April 2019
Differential in vivo biodistribution of 131I-labeled exosomes from diverse cellular origins and its implication in the theranostic application posted_content March 2019
Therapeutic application of extracellular vesicles in kidney disease: promises and challenges journal October 2017
Matrix stiffness regulates microvesicle-induced fibroblast activation journal July 2019
Macrophages as Key Drivers of Cancer Progression and Metastasis journal January 2017
Potential Role of Exosomes in Cancer Metastasis journal July 2019
Follicular Helper T Cell Derived Exosomes Promote B Cell Proliferation and Differentiation in Antibody-Mediated Rejection after Renal Transplantation journal May 2019
Lipidomic characterization of extracellular vesicles in human serum journal January 2019
Distinct expression profiles and functions of Kindlins in breast cancer journal November 2018
Exosomal MALAT1 sponges miR-26a/26b to promote the invasion and metastasis of colorectal cancer via FUT4 enhanced fucosylation and PI3K/Akt pathway journal March 2020
Syndecan-1 induction in lung microenvironment supports the establishment of breast tumor metastases journal July 2018
Colon cancer cells secrete exosomes to promote self-proliferation by shortening mitosis duration and activation of STAT3 in a hypoxic environment journal August 2019
Clinico-pathological significance of exosome marker CD63 expression on cancer cells and stromal cells in gastric cancer journal September 2018
Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker discovery journal March 2016
Oncogenic and non‐malignant pancreatic exosome cargo reveal distinct expression of oncogenic and prognostic factors involved in tumor invasion and metastasis text January 2021
Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo text January 2021
Nanoplasmonic Approaches for Sensitive Detection and Molecular Characterization of Extracellular Vesicles journal May 2019
Increased Circulating Exosomal miRNA-223 Is Associated with Acute Ischemic Stroke journal February 2017
Tissue Factor-Expressing Tumor-Derived Extracellular Vesicles Activate Quiescent Endothelial Cells via Protease-Activated Receptor-1 journal November 2017
An Update on in Vivo Imaging of Extracellular Vesicles as Drug Delivery Vehicles journal February 2018
Integrins: Moonlighting Proteins in Invadosome Formation journal May 2019
Exosome: A Novel Approach to Stimulate Bone Regeneration through Regulation of Osteogenesis and Angiogenesis journal May 2016
Tumour-Derived Extracellular Vesicles (EVs): A Dangerous “Message in A Bottle” for Bone journal September 2019
Exosomes: The Indispensable Messenger in Tumor Pathogenesis and the Rising Star in Antitumor Applications journal March 2019
An analysis of the relationship between metastases and cachexia in lung cancer patients journal August 2016
Chronic myeloid leukemia‐derived exosomes attenuate adipogenesis of adipose derived mesenchymal stem cells via transporting miR‐92a‐3p journal May 2019
Cancer stem cells: A review from origin to therapeutic implications journal July 2019
Microenvironment‐induced TIMP2 loss by cancer‐secreted exosomal miR‐4443 promotes liver metastasis of breast cancer journal January 2020
Oncogenic and Non‐Malignant Pancreatic Exosome Cargo Reveal Distinct Expression of Oncogenic and Prognostic Factors Involved in Tumor Invasion and Metastasis journal January 2019
The extracellular matrix in tumor progression and metastasis journal April 2019
Exosomes: Definition, Role in Tumor Development and Clinical Implications journal May 2018
Liquid biopsy: Potential and challenges journal February 2016
Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK journal February 2017
Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation journal June 2016
Transglutaminase-2 facilitates extracellular vesicle-mediated establishment of the metastatic niche journal February 2020
Exosomal 15-LO2 mediates hypoxia-induced pulmonary artery hypertension in vivo and in vitro journal October 2018
Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity journal January 2019
Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models journal December 2018
Hepatocytes direct the formation of a pro-metastatic niche in the liver journal March 2019
Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping journal September 2019
The role of extracellular vesicles in cancer microenvironment and metastasis: myths and challenges journal January 2019
Extracellular vesicles and their role in glioblastoma journal December 2019
Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales journal October 2018
Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours journal March 2019
Exosomes in Toxicology: Relevance to Chemical Exposure and Pathogenesis of Environmentally Linked Diseases journal May 2017
Extracellular vesicles as trans-genomic agents: Emerging roles in disease and evolution journal May 2017
Hypoxic control of metastasis journal April 2016
Coexisting genomic aberrations associated with lymph node metastasis in breast cancer journal April 2018
Tumor microenvironment participates in metastasis of pancreatic cancer journal July 2018
Understanding extracellular vesicle diversity – current status text January 2021
Physiologic constraints of using exosomes in vivo as systemic delivery vehicles journal July 2019
Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression journal April 2018
A Role for Exosomes in Craniofacial Tissue Engineering and Regeneration journal January 2020
Salivary Extracellular Vesicle-Associated exRNA as Cancer Biomarker journal June 2019
Are Integrins Still Practicable Targets for Anti-Cancer Therapy? journal July 2019
Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue Repair journal October 2018
Extracellular Vesicles and Epigenetic Modifications Are Hallmarks of Melanoma Progression journal December 2019
Exosome-Mediated Signaling in Epithelial to Mesenchymal Transition and Tumor Progression journal December 2018
Uncoupling Traditional Functionalities of Metastasis: The Parting of Ways with Real-Time Assays journal June 2019
N‐glycome inheritance from cells to extracellular vesicles in B16 melanomas journal April 2019
Metabolomic profile of cancer stem cell‐derived exosomes from patients with malignant melanoma journal November 2020
3D Cellular Architecture Affects MicroRNA and Protein Cargo of Extracellular Vesicles journal December 2018
Serum extracellular vesicles contain SPARC and LRG1 as biomarkers of colon cancer and differ by tumour primary location journal December 2019
Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking journal March 2019
14-3-3ζ delivered by hepatocellular carcinoma-derived exosomes impaired anti-tumor function of tumor-infiltrating T lymphocytes journal February 2018
Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E journal March 2018
A rapid, automated surface protein profiling of single circulating exosomes in human blood journal November 2016
Sedentary lifestyle related exosomal release of Hotair from gluteal-femoral fat promotes intestinal cell proliferation journal March 2017
Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles journal August 2017
Blood concentrations of small extracellular vesicles are determined by a balance between abundant secretion and rapid clearance journal November 2019
Recent progress in the emerging role of exosome in hepatocellular carcinoma journal November 2018
Extracellular microRNAs and endothelial hyperglycaemic memory: a therapeutic opportunity? journal June 2016
Extracellular vesicle tetraspanin-8 level predicts distant metastasis in non–small cell lung cancer after concurrent chemoradiation journal March 2020
Exosomes and Exosomal miRNA in Respiratory Diseases journal January 2016
Clinical Advancements in the Targeted Therapies against Liver Fibrosis journal January 2016
RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis journal January 2017
An Update on Novel Therapeutic Warfronts of Extracellular Vesicles (EVs) in Cancer Treatment: Where We Are Standing Right Now and Where to Go in the Future journal July 2019
Exosomal MicroRNA MiR-1246 Promotes Cell Proliferation, Invasion and Drug Resistance by Targeting CCNG2 in Breast Cancer journal January 2017
Potential of Exosomes for the Treatment of Stroke journal December 2018
Exosome: Function and Role in Cancer Metastasis and Drug Resistance journal January 2018
Exosomes: A Promising Avenue for the Diagnosis of Breast Cancer journal January 2019
Proteomics of serum extracellular vesicles identifies a novel COPD biomarker, fibulin-3 from elastic fibres journal January 2021
Formidable challenges to the notion of biologically important roles for dietary small RNAs in ingesting mammals journal July 2017
microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy journal February 2020
Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation journal May 2019
Exosomal proteins as potential markers of tumor diagnosis journal December 2017
Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation journal July 2019
Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer journal July 2018
Fat‐fated microglial dysfunction journal December 2018
Passive Entrapment of Tumor Cells Determines Metastatic Dissemination to Spinal Bone and Other Osseous Tissues text January 2016
Injury factors alter miRNAs profiles of exosomes derived from islets and circulation journal December 2018
Procoagulant and immunogenic properties of melanoma exosomes, microvesicles and apoptotic vesicles journal July 2016
Altered microRNA profiles in plasma exosomes from mesial temporal lobe epilepsy with hippocampal sclerosis journal December 2016
Extracellular Vesicle Integrins Distinguish Unique Cancers journal April 2019
Protease Cargo in Circulating Exosomes of Breast Cancer and Ovarian Cancer Patients journal January 2019
Bone metastasis risk factors in breast cancer journal January 2017
Addressing Patient Specificity in the Engineering of Tumor Models journal September 2019
Exosomes: Origins and Therapeutic Potential for Neurodegenerative Disease journal February 2017
Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes journal May 2017
Cross Talk between Cancer and Mesenchymal Stem Cells through Extracellular Vesicles Carrying Nucleic Acids journal May 2016
The Endosteal Niche in Breast Cancer Bone Metastasis journal March 2020
Exosome-Based Cancer Therapy: Implication for Targeting Cancer Stem Cells journal January 2017
Exosomes: A Rising Star in Failing Hearts journal July 2017
Long Distance Metabolic Regulation through Adipose-Derived Circulating Exosomal miRNAs: A Trail for RNA-Based Therapies? journal August 2017
Extracellular Vesicles as Biomarkers in Cancer Immunotherapy journal September 2020
Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications journal October 2021
Molecular Drivers of Pancreatic Cancer Pathogenesis: Looking Inward to Move Forward journal April 2017
Extracellular Vesicles in Bladder Cancer: Biomarkers and Beyond journal September 2018
Liquid Biopsy for the Detection of Resistance Mechanisms in NSCLC: Comparison of Different Blood Biomarkers journal July 2019
Extracellular Vesicles as Conduits of Non-Coding RNA Emission and Intercellular Transfer in Brain Tumors journal December 2018
Functional Passenger-Strand miRNAs in Exosomes Derived from Human Colon Cancer Cells and Their Heterogeneous Paracrine Effects journal January 2020
Biodistribution of gadolinium- and near infrared-labeled human umbilical cord mesenchymal stromal cell-derived exosomes in tumor bearing mice journal January 2019
Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs journal January 2020

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Related Subjects

60 APPLIED LIFE SCIENCES
59 BASIC BIOLOGICAL SCIENCES
metastasis
cancer microenvironment
mechanisms of disease