Nucleic acid constructs containing orthogonal site selective recombinases (OSSRs)
Patent
·
OSTI ID:1377879
The present invention provides for a recombinant nucleic acid comprising a nucleotide sequence comprising a plurality of constructs, wherein each construct independently comprises a nucleotide sequence of interest flanked by a pair of recombinase recognition sequences. Each pair of recombinase recognition sequences is recognized by a distinct recombinase. Optionally, each construct can, independently, further comprise one or more genes encoding a recombinase capable of recognizing the pair of recombinase recognition sequences of the construct. The recombinase can be an orthogonal (non-cross reacting), site-selective recombinase (OSSR).
- Research Organization:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-05CH11231
- Assignee:
- The Regents of the University of California
- Patent Number(s):
- 9,745,587
- Application Number:
- 13/088,288
- OSTI ID:
- 1377879
- Resource Relation:
- Patent File Date: 2011 Apr 15
- Country of Publication:
- United States
- Language:
- English
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