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Title: Methods and compositions for controlling gene expression by RNA processing

Patent ·
OSTI ID:1377877
; ; ;

The present disclosure provides nucleic acids encoding an RNA recognition sequence positioned proximal to an insertion site for the insertion of a sequence of interest; and host cells genetically modified with the nucleic acids. The present disclosure also provides methods of modifying the activity of a target RNA, and kits and compositions for carrying out the methods.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
The Regents of the University of California
Patent Number(s):
9,745,610
Application Number:
14/248,980
OSTI ID:
1377877
Resource Relation:
Patent File Date: 2014 Apr 09
Country of Publication:
United States
Language:
English

References (8)

Prokaryotic RNAi-Like System and Methods of Use patent-application August 2011
Cas6 Polypeptides and Methods of Use patent-application September 2011
Characterization of CRISPR RNA processing in Clostridium thermocellum and Methanococcus maripaludis journal August 2012
Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease journal September 2010
Kinetics of Paused Ribosome Recycling in Escherichia coli journal November 2009
Versatile RNA-sensing transcriptional regulators for engineering genetic networks journal May 2011
Evolution and classification of the CRISPR–Cas systems journal May 2011
Rationally designed families of orthogonal RNA regulators of translation journal March 2012

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