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Title: Basis for the ICRP’s updated biokinetic model for carbon inhaled as CO 2

Abstract

Here, the International Commission on Radiological Protection (ICRP) is updating its biokinetic and dosimetric models for occupational intake of radionuclides (OIR) in a series of reports called the OIR series. This paper describes the basis for the ICRP's updated biokinetic model for inhalation of radiocarbon as carbon dioxide (CO 2) gas. The updated model is based on biokinetic data for carbon isotopes inhaled as carbon dioxide or injected or ingested as bicarbonate $$({{{\rm{HCO}}}_{3}}^{-}).$$ The data from these studies are expected to apply equally to internally deposited (or internally produced) carbon dioxide and bicarbonate based on comparison of excretion rates for the two administered forms and the fact that carbon dioxide and bicarbonate are largely carried in a common form (CO 2–H$${{{\rm{CO}}}_{3}}^{-})$$ in blood. Compared with dose estimates based on current ICRP biokinetic models for inhaled carbon dioxide or ingested carbon, the updated model will result in a somewhat higher dose estimate for 14C inhaled as CO 2 and a much lower dose estimate for 14C ingested as bicarbonate.

Authors:
ORCiD logo [1]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1376333
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Journal of Radiological Protection
Additional Journal Information:
Journal Volume: 37; Journal Issue: 2; Journal ID: ISSN 0952-4746
Publisher:
IOP Publishing
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; biokinetics; ICRP; carbon dioxide; bicarbonate

Citation Formats

Leggett, Richard W. Basis for the ICRP’s updated biokinetic model for carbon inhaled as CO2. United States: N. p., 2017. Web. doi:10.1088/1361-6498/aa5544.
Leggett, Richard W. Basis for the ICRP’s updated biokinetic model for carbon inhaled as CO2. United States. doi:10.1088/1361-6498/aa5544.
Leggett, Richard W. Thu . "Basis for the ICRP’s updated biokinetic model for carbon inhaled as CO2". United States. doi:10.1088/1361-6498/aa5544. https://www.osti.gov/servlets/purl/1376333.
@article{osti_1376333,
title = {Basis for the ICRP’s updated biokinetic model for carbon inhaled as CO2},
author = {Leggett, Richard W.},
abstractNote = {Here, the International Commission on Radiological Protection (ICRP) is updating its biokinetic and dosimetric models for occupational intake of radionuclides (OIR) in a series of reports called the OIR series. This paper describes the basis for the ICRP's updated biokinetic model for inhalation of radiocarbon as carbon dioxide (CO2) gas. The updated model is based on biokinetic data for carbon isotopes inhaled as carbon dioxide or injected or ingested as bicarbonate $({{{\rm{HCO}}}_{3}}^{-}).$ The data from these studies are expected to apply equally to internally deposited (or internally produced) carbon dioxide and bicarbonate based on comparison of excretion rates for the two administered forms and the fact that carbon dioxide and bicarbonate are largely carried in a common form (CO2–H${{{\rm{CO}}}_{3}}^{-})$ in blood. Compared with dose estimates based on current ICRP biokinetic models for inhaled carbon dioxide or ingested carbon, the updated model will result in a somewhat higher dose estimate for 14C inhaled as CO2 and a much lower dose estimate for 14C ingested as bicarbonate.},
doi = {10.1088/1361-6498/aa5544},
journal = {Journal of Radiological Protection},
number = 2,
volume = 37,
place = {United States},
year = {Thu Mar 02 00:00:00 EST 2017},
month = {Thu Mar 02 00:00:00 EST 2017}
}

Journal Article:
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