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Title: Microneedle arrays for biosensing and drug delivery

Abstract

Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a^ device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

Inventors:
; ; ; ; ;
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1376225
Patent Number(s):
9,737,247
Application Number:
14/342,536
Assignee:
The Regents of the University of California SNL-A
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Aug 31
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Wang, Joseph, Windmiller, Joshua Ray, Narayan, Roger, Miller, Philip, Polsky, Ronen, and Edwards, Thayne L. Microneedle arrays for biosensing and drug delivery. United States: N. p., 2017. Web.
Wang, Joseph, Windmiller, Joshua Ray, Narayan, Roger, Miller, Philip, Polsky, Ronen, & Edwards, Thayne L. Microneedle arrays for biosensing and drug delivery. United States.
Wang, Joseph, Windmiller, Joshua Ray, Narayan, Roger, Miller, Philip, Polsky, Ronen, and Edwards, Thayne L. Tue . "Microneedle arrays for biosensing and drug delivery". United States. doi:. https://www.osti.gov/servlets/purl/1376225.
@article{osti_1376225,
title = {Microneedle arrays for biosensing and drug delivery},
author = {Wang, Joseph and Windmiller, Joshua Ray and Narayan, Roger and Miller, Philip and Polsky, Ronen and Edwards, Thayne L.},
abstractNote = {Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a^ device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 22 00:00:00 EDT 2017},
month = {Tue Aug 22 00:00:00 EDT 2017}
}

Patent:

Works referenced in this record:

Body fluid sampling/fluid delivery device
patent-application, December 2011


Enzyme-Logic Biosensing
patent-application, March 2013


Electrically Actuatable Smart Nanoporous Membrane for Pulsatile Drug Release
journal, March 2011

  • Jeon, Gumhye; Yang, Seung Yun; Byun, Jinseok
  • Nano Letters, Vol. 11, Issue 3, p. 1284-1288
  • DOI: 10.1021/nl104329y

Microneedle array-based carbon paste amperometric sensors and biosensors
journal, January 2011

  • Windmiller, Joshua Ray; Zhou, Nandi; Chuang, Min-Chieh
  • Analyst, Vol. 136, Issue 9, p. 1846-1851
  • DOI: 10.1039/C1AN00012H

Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing
journal, March 2011

  • Miller, Philip R.; Gittard, Shaun D.; Edwards, Thayne L.
  • Biomicrofluidics, Vol. 5, Issue 1, Article No. 013415
  • DOI: 10.1063/1.3569945

Bicomponent Microneedle Array Biosensor for Minimally-Invasive Glutamate Monitoring
journal, September 2011

  • Windmiller, Joshua Ray; Valdés-Ramírez, Gabriela; Zhou, Nandi
  • Electroanalysis, Vol. 23, Issue 10, p. 2302-2309
  • DOI: 10.1002/elan.201100361