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Title: Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA

Authors:
ORCiD logo [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [2];  [2];  [1];  [2];  [1]
  1. Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States
  2. Vanderbilt University School of Medicine, Department of Biochemistry, Nashville, Tennessee 37232, United States
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
INDUSTRY
OSTI Identifier:
1374634
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of the American Chemical Society; Journal Volume: 139; Journal Issue: 25
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Schlegel, Mark K., Foster, Donald J., Kel’in, Alexander V., Zlatev, Ivan, Bisbe, Anna, Jayaraman, Muthusamy, Lackey, Jeremy G., Rajeev, Kallanthottathil G., Charissé, Klaus, Harp, Joel, Pallan, Pradeep S., Maier, Martin A., Egli, Martin, and Manoharan, Muthiah. Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA. United States: N. p., 2017. Web. doi:10.1021/jacs.7b02694.
Schlegel, Mark K., Foster, Donald J., Kel’in, Alexander V., Zlatev, Ivan, Bisbe, Anna, Jayaraman, Muthusamy, Lackey, Jeremy G., Rajeev, Kallanthottathil G., Charissé, Klaus, Harp, Joel, Pallan, Pradeep S., Maier, Martin A., Egli, Martin, & Manoharan, Muthiah. Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA. United States. doi:10.1021/jacs.7b02694.
Schlegel, Mark K., Foster, Donald J., Kel’in, Alexander V., Zlatev, Ivan, Bisbe, Anna, Jayaraman, Muthusamy, Lackey, Jeremy G., Rajeev, Kallanthottathil G., Charissé, Klaus, Harp, Joel, Pallan, Pradeep S., Maier, Martin A., Egli, Martin, and Manoharan, Muthiah. Mon . "Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA". United States. doi:10.1021/jacs.7b02694.
@article{osti_1374634,
title = {Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA},
author = {Schlegel, Mark K. and Foster, Donald J. and Kel’in, Alexander V. and Zlatev, Ivan and Bisbe, Anna and Jayaraman, Muthusamy and Lackey, Jeremy G. and Rajeev, Kallanthottathil G. and Charissé, Klaus and Harp, Joel and Pallan, Pradeep S. and Maier, Martin A. and Egli, Martin and Manoharan, Muthiah},
abstractNote = {},
doi = {10.1021/jacs.7b02694},
journal = {Journal of the American Chemical Society},
number = 25,
volume = 139,
place = {United States},
year = {Mon Jun 19 00:00:00 EDT 2017},
month = {Mon Jun 19 00:00:00 EDT 2017}
}