skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Multifunctional, Tunable Metal–Organic Framework Materials Platform for Bioimaging Applications [A Multifunctional Tunable MOF Materials Platform for Bio-Imaging Applications]

Abstract

Herein, we describe a novel multifunctional metal–organic framework (MOF) materials platform that displays both porosity and tunable emission properties as a function of the metal identity (Eu, Nd, and tuned compositions of Nd/Yb). Their emission collectively spans the deep red to near-infrared (NIR) spectral region (~614–1350 nm), which is highly relevant for in vivo bioimaging. These new materials meet important prerequisites as relevant to biological processes: they are minimally toxic to living cells and retain structural integrity in water and phosphate-buffered saline. To assess their viability as optical bioimaging agents, we successfully synthesized the nanoscale Eu analog as a proof-of-concept system in this series. In vitro studies show that it is cell-permeable in individual RAW 264.7 mouse macrophage and HeLa human cervical cancer tissue culture cells. The efficient discrimination between the Eu emission and cell autofluorescence was achieved with hyperspectral confocal fluorescence microscopy, used here for the first time to characterize MOF materials. Importantly, this is the first report that documents the long-term conservation of the intrinsic emission in live cells of a fluorophore-based MOF to date (up to 48 h). As a result this finding, in conjunction with the materials’ very low toxicity, validates the biocompatibility in these systemsmore » and qualifies them as promising for use in long-term tracking and biodistribution studies.« less

Authors:
ORCiD logo [1];  [1];  [1];  [1];  [1];  [1];  [1];  [2]
  1. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
  2. Argonne National Lab. (ANL), Argonne, IL (United States)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22), Scientific User Facilities Division
OSTI Identifier:
1373947
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
ACS Applied Materials and Interfaces
Additional Journal Information:
Journal Volume: 9; Journal Issue: 27; Journal ID: ISSN 1944-8244
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; metal-organic framework; bio-imaging; emission; lanthanide; near-infrared

Citation Formats

Sava Gallis, Dorina F., Rohwer, Lauren E. S., Rodriguez, Mark A., Barnhart-Dailey, Meghan C., Butler, Kimberly S., Luk, Ting S., Timlin, Jerilyn A., and Chapman, Karena W. Multifunctional, Tunable Metal–Organic Framework Materials Platform for Bioimaging Applications [A Multifunctional Tunable MOF Materials Platform for Bio-Imaging Applications]. United States: N. p., 2017. Web. doi:10.1021/acsami.7b05859.
Sava Gallis, Dorina F., Rohwer, Lauren E. S., Rodriguez, Mark A., Barnhart-Dailey, Meghan C., Butler, Kimberly S., Luk, Ting S., Timlin, Jerilyn A., & Chapman, Karena W. Multifunctional, Tunable Metal–Organic Framework Materials Platform for Bioimaging Applications [A Multifunctional Tunable MOF Materials Platform for Bio-Imaging Applications]. United States. doi:10.1021/acsami.7b05859.
Sava Gallis, Dorina F., Rohwer, Lauren E. S., Rodriguez, Mark A., Barnhart-Dailey, Meghan C., Butler, Kimberly S., Luk, Ting S., Timlin, Jerilyn A., and Chapman, Karena W. Wed . "Multifunctional, Tunable Metal–Organic Framework Materials Platform for Bioimaging Applications [A Multifunctional Tunable MOF Materials Platform for Bio-Imaging Applications]". United States. doi:10.1021/acsami.7b05859. https://www.osti.gov/servlets/purl/1373947.
@article{osti_1373947,
title = {Multifunctional, Tunable Metal–Organic Framework Materials Platform for Bioimaging Applications [A Multifunctional Tunable MOF Materials Platform for Bio-Imaging Applications]},
author = {Sava Gallis, Dorina F. and Rohwer, Lauren E. S. and Rodriguez, Mark A. and Barnhart-Dailey, Meghan C. and Butler, Kimberly S. and Luk, Ting S. and Timlin, Jerilyn A. and Chapman, Karena W.},
abstractNote = {Herein, we describe a novel multifunctional metal–organic framework (MOF) materials platform that displays both porosity and tunable emission properties as a function of the metal identity (Eu, Nd, and tuned compositions of Nd/Yb). Their emission collectively spans the deep red to near-infrared (NIR) spectral region (~614–1350 nm), which is highly relevant for in vivo bioimaging. These new materials meet important prerequisites as relevant to biological processes: they are minimally toxic to living cells and retain structural integrity in water and phosphate-buffered saline. To assess their viability as optical bioimaging agents, we successfully synthesized the nanoscale Eu analog as a proof-of-concept system in this series. In vitro studies show that it is cell-permeable in individual RAW 264.7 mouse macrophage and HeLa human cervical cancer tissue culture cells. The efficient discrimination between the Eu emission and cell autofluorescence was achieved with hyperspectral confocal fluorescence microscopy, used here for the first time to characterize MOF materials. Importantly, this is the first report that documents the long-term conservation of the intrinsic emission in live cells of a fluorophore-based MOF to date (up to 48 h). As a result this finding, in conjunction with the materials’ very low toxicity, validates the biocompatibility in these systems and qualifies them as promising for use in long-term tracking and biodistribution studies.},
doi = {10.1021/acsami.7b05859},
journal = {ACS Applied Materials and Interfaces},
issn = {1944-8244},
number = 27,
volume = 9,
place = {United States},
year = {2017},
month = {6}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Citation Metrics:
Cited by: 12 works
Citation information provided by
Web of Science

Save / Share:

Works referencing / citing this record:

Versatile bimetallic lanthanide metal-organic frameworks for tunable emission and efficient fluorescence sensing
journal, April 2018


Versatile bimetallic lanthanide metal-organic frameworks for tunable emission and efficient fluorescence sensing
journal, April 2018


Design of lanthanide-based metal–organic frameworks with enhanced near-infrared emission
journal, January 2020

  • Nguyen, Tu N.; Eliseeva, Svetlana V.; Gładysiak, Andrzej
  • Journal of Materials Chemistry A
  • DOI: 10.1039/d0ta01677b