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Title: The Third Ambient Aspirin Polymorph

Abstract

Polymorphism in aspirin (acetylsalicylic acid), one of the most widely consumed medications, was equivocal until the structure of a second polymorph II, similar in structure to the original form I, was reported in 2005. Here, the third ambient polymorph of aspirin is described. Lastly, it was crystallized from the melt and its structure was determined using a combination of X-ray powder diffraction analysis and crystal structure prediction algorithms.

Authors:
ORCiD logo [1];  [1];  [2];  [3];  [4];  [1];  [5]
  1. New York Univ., New York City, NY (United States)
  2. Univ. of Nevada, Las Vegas, NV (United States)
  3. Goethe Univ., Frankfurt am Main (Germany)
  4. Argonne National Lab. (ANL), Argonne, IL (United States)
  5. New York Univ., New York City, NY (United States); Waseda Univ., Tokyo (Japan)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA); National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22), Scientific User Facilities Division
OSTI Identifier:
1373897
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Crystal Growth and Design
Additional Journal Information:
Journal Volume: 17; Journal Issue: 6; Journal ID: ISSN 1528-7483
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Shtukenberg, Alexander G., Hu, Chunhua T., Zhu, Qiang, Schmidt, Martin U., Xu, Wenqian, Tan, Melissa, and Kahr, Bart. The Third Ambient Aspirin Polymorph. United States: N. p., 2017. Web. doi:10.1021/acs.cgd.7b00673.
Shtukenberg, Alexander G., Hu, Chunhua T., Zhu, Qiang, Schmidt, Martin U., Xu, Wenqian, Tan, Melissa, & Kahr, Bart. The Third Ambient Aspirin Polymorph. United States. doi:10.1021/acs.cgd.7b00673.
Shtukenberg, Alexander G., Hu, Chunhua T., Zhu, Qiang, Schmidt, Martin U., Xu, Wenqian, Tan, Melissa, and Kahr, Bart. Wed . "The Third Ambient Aspirin Polymorph". United States. doi:10.1021/acs.cgd.7b00673. https://www.osti.gov/servlets/purl/1373897.
@article{osti_1373897,
title = {The Third Ambient Aspirin Polymorph},
author = {Shtukenberg, Alexander G. and Hu, Chunhua T. and Zhu, Qiang and Schmidt, Martin U. and Xu, Wenqian and Tan, Melissa and Kahr, Bart},
abstractNote = {Polymorphism in aspirin (acetylsalicylic acid), one of the most widely consumed medications, was equivocal until the structure of a second polymorph II, similar in structure to the original form I, was reported in 2005. Here, the third ambient polymorph of aspirin is described. Lastly, it was crystallized from the melt and its structure was determined using a combination of X-ray powder diffraction analysis and crystal structure prediction algorithms.},
doi = {10.1021/acs.cgd.7b00673},
journal = {Crystal Growth and Design},
number = 6,
volume = 17,
place = {United States},
year = {Wed May 17 00:00:00 EDT 2017},
month = {Wed May 17 00:00:00 EDT 2017}
}

Journal Article:
Free Publicly Available Full Text
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Cited by: 5 works
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