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Title: De novo design of allosteric proteins

Abstract

Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.

Inventors:
; ;
Publication Date:
Research Org.:
President and Fellows of Harvard College, Cambridge, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1373718
Patent Number(s):
9,721,061
Application Number:
15/120,228
Assignee:
President and Fellows of Harvard College CHO
DOE Contract Number:  
FG02-02ER63445
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Feb 20
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Raman, Srivatsan, Taylor, Noah D., and Church, George M.. De novo design of allosteric proteins. United States: N. p., 2017. Web.
Raman, Srivatsan, Taylor, Noah D., & Church, George M.. De novo design of allosteric proteins. United States.
Raman, Srivatsan, Taylor, Noah D., and Church, George M.. Tue . "De novo design of allosteric proteins". United States. doi:. https://www.osti.gov/servlets/purl/1373718.
@article{osti_1373718,
title = {De novo design of allosteric proteins},
author = {Raman, Srivatsan and Taylor, Noah D. and Church, George M.},
abstractNote = {Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 01 00:00:00 EDT 2017},
month = {Tue Aug 01 00:00:00 EDT 2017}
}

Patent:

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Works referenced in this record:

The structural basis of allosteric regulation in proteins
journal, March 2009


Light-activated DNA binding in a designed allosteric protein
journal, July 2008

  • Strickland, D.; Moffat, K.; Sosnick, T. R.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 31, p. 10709-10714
  • DOI: 10.1073/pnas.0709610105