skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Modeling Zika plasma viral dynamics in non-human primates: insights into viral pathogenesis and antiviral strategies

Abstract

The recent outbreak of Zika virus (ZIKV) has been associated with fetal abnormalities and neurological complications, prompting global concern. Here we present the first mathematical analysis of the within-host dynamics of plasma ZiKV burden in a non-human primate model, allowing for characterization of the growth and clearance of ZIKV within an individual macaque.

Authors:
 [1];  [2];  [3];  [4];  [5];  [5];  [5];  [1]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  2. Univ. of Paris (France). IAME
  3. Univ. of Paris (France)
  4. Aix-Marseille Univ. (France)
  5. Harvard Univ., Cambridge, MA (United States). Center for Virology and Vaccine Research
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH)
OSTI Identifier:
1373602
Alternate Identifier(s):
OSTI ID: 1330177
Report Number(s):
LA-UR-16-28095
Grant/Contract Number:  
AC52-06NA25396
Resource Type:
Journal Article: Published Article
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Biological Science

Citation Formats

Best, Katharine, Guedj, Jeremie, Madelain, Vincent, de Lamballerie, Xavier, L, So-Yonim, Osuna, Christa E, Whitney, James, and Perelson, Alan S. Modeling Zika plasma viral dynamics in non-human primates: insights into viral pathogenesis and antiviral strategies. United States: N. p., 2016. Web. doi:10.1073/pnas.1704011114.
Best, Katharine, Guedj, Jeremie, Madelain, Vincent, de Lamballerie, Xavier, L, So-Yonim, Osuna, Christa E, Whitney, James, & Perelson, Alan S. Modeling Zika plasma viral dynamics in non-human primates: insights into viral pathogenesis and antiviral strategies. United States. doi:10.1073/pnas.1704011114.
Best, Katharine, Guedj, Jeremie, Madelain, Vincent, de Lamballerie, Xavier, L, So-Yonim, Osuna, Christa E, Whitney, James, and Perelson, Alan S. Mon . "Modeling Zika plasma viral dynamics in non-human primates: insights into viral pathogenesis and antiviral strategies". United States. doi:10.1073/pnas.1704011114.
@article{osti_1373602,
title = {Modeling Zika plasma viral dynamics in non-human primates: insights into viral pathogenesis and antiviral strategies},
author = {Best, Katharine and Guedj, Jeremie and Madelain, Vincent and de Lamballerie, Xavier and L, So-Yonim and Osuna, Christa E and Whitney, James and Perelson, Alan S.},
abstractNote = {The recent outbreak of Zika virus (ZIKV) has been associated with fetal abnormalities and neurological complications, prompting global concern. Here we present the first mathematical analysis of the within-host dynamics of plasma ZiKV burden in a non-human primate model, allowing for characterization of the growth and clearance of ZIKV within an individual macaque.},
doi = {10.1073/pnas.1704011114},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Oct 24 00:00:00 EDT 2016},
month = {Mon Oct 24 00:00:00 EDT 2016}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at 10.1073/pnas.1704011114

Citation Metrics:
Cited by: 11 works
Citation information provided by
Web of Science

Save / Share: