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Title: Deciphering Antibiotic Resistance.


Abstract not provided.

; ; ;
Publication Date:
Research Org.:
Sandia National Lab. (SNL-CA), Livermore, CA (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
Report Number(s):
DOE Contract Number:
Resource Type:
Resource Relation:
Conference: Proposed for presentation at the Symposium held July 27, 2016 in Livermore, CA.
Country of Publication:
United States

Citation Formats

Hess, Selene, Curtis, Deanna Joy, LaBauve, Annette Estelle, and Poorey, Kunal. Deciphering Antibiotic Resistance.. United States: N. p., 2016. Web.
Hess, Selene, Curtis, Deanna Joy, LaBauve, Annette Estelle, & Poorey, Kunal. Deciphering Antibiotic Resistance.. United States.
Hess, Selene, Curtis, Deanna Joy, LaBauve, Annette Estelle, and Poorey, Kunal. 2016. "Deciphering Antibiotic Resistance.". United States. doi:.
title = {Deciphering Antibiotic Resistance.},
author = {Hess, Selene and Curtis, Deanna Joy and LaBauve, Annette Estelle and Poorey, Kunal},
abstractNote = {Abstract not provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = 2016,
month = 7

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  • Staphylococci were isolated from rural and urban populations in Iraq, which were not known to be exposed to either heavy metals or antibiotics. The antibiotic and heavy metal resistance patterns of these strains were analyzed in both mannitol-fermenting and nonfermenting strains. Over 90% of the strains were resistant to at least one of the following antibiotics: penicillin, chloramphenicol, erythromycin, tetracycline, cephalothin, lincomycin, and methicillin. In general, mannitol-fermenting strains were resistant to penicillin and cupric ions. Mannitol-negative strains were more frequently associated with mercuric ion and tetracycline resistance. Although resistance to penicillin and tetracycline can coexist, the combination of penicillin resistancemore » and tetracycline resistance usually occurred in mannitol-negative strains. The possibility of selection of heavy metal-resistant strains due to exposure to toxic levels of methylmercury was examined. No significant increase in mercuric ion-resistant strains of staphylococci or Escherichia coli were detected in exposed populations as compared to control groups. The possible reasons for this result are discussed.« less
  • Staphylococci were isolated from clinical specimens obtained from patients not known to be exposed to abnormal levels of heavy metals. The antibiotic and heavy metal resistance patterns of these strains were determined by using a disk diffusion test and computer sorting. Though not absolute, an association of resistance to mercury and tetracycline in coagulase-negative strains was found, in contrast to resistance to copper and penicillin in coagulase-producing strains. A high degree of correlation was observed between the resistance to phenyl mercury and inorganic mercury, but no correlation was obtained between resistance to methylmercury and other metals. In general, strains resistantmore » to many agents were usually coagulase negative. A possible mechanism and implications of these associations are considered. 31 references.« less
  • Seismic sequence stratigraphy allows deciphering continental basin evolution and identifies tectonic subsidence which in turn controls longevity, type and distribution seismic facies (oblique progradational facies [OPF]; fault-front facies [FFF]). Depositional and structural geometries of continental basin-fill sequences reflect type and magnitude of tectonism. Sequence stratigraphy delineates five stages of basic development: (1) a pre-faulting sagging stage of the basin, (2) growth-faulting, (3) collapse of the intrabasin graben, (4) tectonic compression, and (5) deactivation. The first stages record a continuum of protracted extension during only one rifting phase. However compression and deactivation reflect basinal shrinking' evidenced by folded basin-fill strata ormore » offlap geometry of sequences. The delicate balance between aggradation and progradation in the OPF provides a mechanism to quantify tectonic subsidence. Initiative of growing-faulting terminates OPF by increasing depositional slopes in a later direction. Likewise, the authors explain the absence of FFF at the onset of growth-faulting with the eastern intrabasin horst replacing the Toana Range as adjunct footwall to the basin. The overall progradational signature of seismic facies particularly during the sagging stage is the results of the depositional system adjusting to a new baselevel (forced regression).« less
  • A model has been developed to predict piezoresistivity in Silicone/Nickel Nanostrand composites. This model combines the theory of quantum mechanical tunneling with percolation theory to obtain macroscopic composite resistivity as a function of strain from quantum mechanical principles and statistical characterization of constituent morphology. It has been shown that a model incorporating quantum mechanical tunneling and percolation theory can be used to predict piezoresistivity in Silicone/Nickel Nanostrand composites. The predictions of this model qualitatively demonstrate the large drop in resistivity with strain that these composites exhibit. The quantitative accuracy of the model was shown to be usually within one ordermore » of magnitude. Further work must be done to obtain an empirical distribution of inter-nanostrand gap distances, the tunneling barrier height ({lambda}), and the fraction of conductive junctions as a function of strain for these composites.« less
  • Abstract not provided.