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Title: Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses

Abstract

Ion mobility spectrometry (IMS) is a widely used analytical technique for rapid molecular separations in the gas phase. IMS alone is useful, but its coupling with mass spectrometry (MS) and front-end separations has been extremely beneficial for increasing measurement sensitivity, peak capacity of complex mixtures, and the scope of molecular information in biological and environmental sample analyses. Multiple studies in disease screening and environmental evaluations have even shown these IMS-based multidimensional separations extract information not possible with each technique individually. This review highlights 3-dimensional separations using IMS-MS in conjunction with a range of front-end techniques, such as gas chromatography (GC), supercritical fluid chromatography (SFC), liquid chromatography (LC), solid phase extractions (SPE), capillary electrophoresis (CE), field asymmetric ion mobility spectrometry (FAIMS), and microfluidic devices. The origination, current state, various applications, and future capabilities for these multidimensional approaches are described to provide insight into the utility and potential of each technique.

Authors:
 [1];  [1];  [2];  [1];  [1];  [1];  [1];  [1];  [1];  [1]
  1. Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352,
  2. Skaggs School of Pharmacy and Pharmaceutical Sciences, Anschutz Medical Campus, University of Colorado, Denver, Colorado 80045
Publication Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
Sponsoring Org.:
USDOE
OSTI Identifier:
1373001
Report Number(s):
PNNL-SA-121198
Journal ID: ISSN 1936-1327; 48680; 48199; 49531; KP1601010; 453040220; 400412000; WN9030198
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Annual Review of Analytical Chemistry; Journal Volume: 10; Journal Issue: 1
Country of Publication:
United States
Language:
English
Subject:
ion mobility; Spectrometry; Mass spectrometry; Environmental Molecular Sciences Laboratory

Citation Formats

Zheng, Xueyun, Wojcik, Roza, Zhang, Xing, Ibrahim, Yehia M., Burnum-Johnson, Kristin E., Orton, Daniel J., Monroe, Matthew E., Moore, Ronald J., Smith, Richard D., and Baker, Erin S.. Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses. United States: N. p., 2017. Web. doi:10.1146/annurev-anchem-061516-045212.
Zheng, Xueyun, Wojcik, Roza, Zhang, Xing, Ibrahim, Yehia M., Burnum-Johnson, Kristin E., Orton, Daniel J., Monroe, Matthew E., Moore, Ronald J., Smith, Richard D., & Baker, Erin S.. Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses. United States. doi:10.1146/annurev-anchem-061516-045212.
Zheng, Xueyun, Wojcik, Roza, Zhang, Xing, Ibrahim, Yehia M., Burnum-Johnson, Kristin E., Orton, Daniel J., Monroe, Matthew E., Moore, Ronald J., Smith, Richard D., and Baker, Erin S.. Mon . "Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses". United States. doi:10.1146/annurev-anchem-061516-045212.
@article{osti_1373001,
title = {Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses},
author = {Zheng, Xueyun and Wojcik, Roza and Zhang, Xing and Ibrahim, Yehia M. and Burnum-Johnson, Kristin E. and Orton, Daniel J. and Monroe, Matthew E. and Moore, Ronald J. and Smith, Richard D. and Baker, Erin S.},
abstractNote = {Ion mobility spectrometry (IMS) is a widely used analytical technique for rapid molecular separations in the gas phase. IMS alone is useful, but its coupling with mass spectrometry (MS) and front-end separations has been extremely beneficial for increasing measurement sensitivity, peak capacity of complex mixtures, and the scope of molecular information in biological and environmental sample analyses. Multiple studies in disease screening and environmental evaluations have even shown these IMS-based multidimensional separations extract information not possible with each technique individually. This review highlights 3-dimensional separations using IMS-MS in conjunction with a range of front-end techniques, such as gas chromatography (GC), supercritical fluid chromatography (SFC), liquid chromatography (LC), solid phase extractions (SPE), capillary electrophoresis (CE), field asymmetric ion mobility spectrometry (FAIMS), and microfluidic devices. The origination, current state, various applications, and future capabilities for these multidimensional approaches are described to provide insight into the utility and potential of each technique.},
doi = {10.1146/annurev-anchem-061516-045212},
journal = {Annual Review of Analytical Chemistry},
number = 1,
volume = 10,
place = {United States},
year = {Mon Jun 12 00:00:00 EDT 2017},
month = {Mon Jun 12 00:00:00 EDT 2017}
}