Shape Recovery with Concomitant Mechanical Strengthening of Amphiphilic Shape Memory Polymers in Warm Water

Zhang, Ben; DeBartolo, Janae E.; Song, Jie

doi:10.1021/acsami.6b14167

Title: Shape Recovery with Concomitant Mechanical Strengthening of Amphiphilic Shape Memory Polymers in Warm Water

Journal Article · Thu Jan 26 00:00:00 EST 2017 · ACS Applied Materials and Interfaces

DOI:https://doi.org/10.1021/acsami.6b14167· OSTI ID:1372068

Zhang, Ben; DeBartolo, Janae E.; Song, Jie

Maintaining adequate or enhancing mechanical properties of shape memory polymers (SMPs) after shape recovery in an aqueous environment are greatly desired for biomedical applications of SMPs as self-fitting tissue scaffolds or minimally invasive surgical implants. Here we report stable temporary shape fixing and facile shape recovery of biodegradable triblock amphiphilic SMPs containing a poly(ethylene glycol) (PEG) center block and flanking poly(lactic acid) or poly(lactic-co-glycolic acid) blocks in warm water, accompanied with concomitant enhanced mechanical strengths. Differential scanning calorimetry (DSC), wide-angle X-ray diffraction (WXRD) and small-angle X-ray scattering (SAXS) analyses revealed that the unique stiffening of the amphiphilic SMPs upon hydration was due to hydration-driven microphase separation and PEG crystallization. We further demonstrated that the chemical composition of degradable blocks in these SMPs could be tailored to affect the persistence of hydration-induced stiffening upon subsequent dehydration. These properties combined open new horizons for these amphiphilic SMPs for smart weight-bearing in vivo applications (e.g. as self-fitting intervertebral discs). In conclusion, this study also provides a new material design strategy to strengthen polymers in aqueous environment in general.

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1372068

Journal Information:: ACS Applied Materials and Interfaces, Vol. 9, Issue 5; ISSN 1944-8244

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 22 works

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Multifunctional scaffolds for facile implantation, spontaneous fixation, and accelerated long bone regeneration in rodents Zhang, Ben; Skelly, Jordan D.; Maalouf, Jacob R. Science Translational Medicine, Vol. 11, Issue 502 https://doi.org/10.1126/scitranslmed.aau7411	journal	July 2019
Carbon nanotubes array reinforced shape-memory epoxy with fast responses to low-power microwaves Chen, Lei; Li, Wei; Liu, Xiaopei Journal of Applied Polymer Science, Vol. 136, Issue 21 https://doi.org/10.1002/app.47563	journal	January 2019
Synthesis and properties of shape memory polymers of LLA, TMC, and ε‐CL terpolymers Wen, Shaohua; Li, Yongfei Polymers for Advanced Technologies, Vol. 31, Issue 5 https://doi.org/10.1002/pat.4840	journal	December 2019
3D-Printed Biomaterials for Guided Tissue Regeneration Zhang, Ben; Song, Jie Small Methods, Vol. 2, Issue 9 https://doi.org/10.1002/smtd.201700306	journal	January 2018

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36 MATERIALS SCIENCE
hydration-induced stiffening effect
shape memory
amphiphilic biodegradable polymers
minimal invasive surgery
weight-bearing implantation

Title: Shape Recovery with Concomitant Mechanical Strengthening of Amphiphilic Shape Memory Polymers in Warm Water

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