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Title: Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
DODNIH
OSTI Identifier:
1368315
Resource Type:
Journal Article
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 8; Journal Issue: 06, 2017; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Xu, Wei, Luthra, Priya, Wu, Chao, Batra, Jyoti, Leung, Daisy W., Basler, Christopher F., and Amarasinghe, Gaya K. Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis. United States: N. p., 2017. Web. doi:10.1038/ncomms15576.
Xu, Wei, Luthra, Priya, Wu, Chao, Batra, Jyoti, Leung, Daisy W., Basler, Christopher F., & Amarasinghe, Gaya K. Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis. United States. doi:10.1038/ncomms15576.
Xu, Wei, Luthra, Priya, Wu, Chao, Batra, Jyoti, Leung, Daisy W., Basler, Christopher F., and Amarasinghe, Gaya K. Thu . "Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis". United States. doi:10.1038/ncomms15576.
@article{osti_1368315,
title = {Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis},
author = {Xu, Wei and Luthra, Priya and Wu, Chao and Batra, Jyoti and Leung, Daisy W. and Basler, Christopher F. and Amarasinghe, Gaya K.},
abstractNote = {},
doi = {10.1038/ncomms15576},
journal = {Nature Communications},
issn = {2041-1723},
number = 06, 2017,
volume = 8,
place = {United States},
year = {2017},
month = {6}
}

Works referenced in this record:

The Buccaneer software for automated model building. 1. Tracing protein chains
journal, August 2006


Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus
journal, October 2015

  • Messaoudi, Ilhem; Amarasinghe, Gaya K.; Basler, Christopher F.
  • Nature Reviews Microbiology, Vol. 13, Issue 11
  • DOI: 10.1038/nrmicro3524

Overview of the CCP 4 suite and current developments
journal, March 2011

  • Winn, Martyn D.; Ballard, Charles C.; Cowtan, Kevin D.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4
  • DOI: 10.1107/S0907444910045749

Camouflage and Misdirection: The Full-On Assault of Ebola Virus Disease
journal, October 2014


HKL -3000: the integration of data reduction and structure solution – from diffraction images to an initial model in minutes
journal, July 2006

  • Minor, Wladek; Cymborowski, Marcin; Otwinowski, Zbyszek
  • Acta Crystallographica Section D Biological Crystallography, Vol. 62, Issue 8
  • DOI: 10.1107/S0907444906019949

Ebola Virus Transcription Activator VP30 Is a Zinc-Binding Protein
journal, March 2003


Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome
journal, July 2013


Ebola Virus VP30 Is an RNA Binding Protein
journal, June 2007

  • John, S. P.; Wang, T.; Steffen, S.
  • Journal of Virology, Vol. 81, Issue 17
  • DOI: 10.1128/JVI.02523-06

Phosphorylation of Ebola Virus VP30 Influences the Composition of the Viral Nucleocapsid Complex: IMPACT ON VIRAL TRANSCRIPTION AND REPLICATION
journal, March 2013

  • Biedenkopf, Nadine; Hartlieb, Bettina; Hoenen, Thomas
  • Journal of Biological Chemistry, Vol. 288, Issue 16
  • DOI: 10.1074/jbc.M113.461285

Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses
journal, January 2016

  • Baker, Laura E.; Ellena, Jeffrey F.; Handing, Katarzyna B.
  • Acta Crystallographica Section D Structural Biology, Vol. 72, Issue 1
  • DOI: 10.1107/S2059798315021439

The Ebola virus ribonucleoprotein complex: A novel VP30–L interaction identified
journal, March 2009


The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis
journal, October 2016


MolProbity: all-atom contacts and structure validation for proteins and nucleic acids
journal, May 2007

  • Davis, I. W.; Leaver-Fay, A.; Chen, V. B.
  • Nucleic Acids Research, Vol. 35, Issue Web Server
  • DOI: 10.1093/nar/gkm216

Ebola Virus VP30-Mediated Transcription Is Regulated by RNA Secondary Structure Formation
journal, September 2002


Phosphorylation of Marburg Virus VP30 at Serines 40 and 42 Is Critical for Its Interaction with NP Inclusions
journal, August 2001

  • Modrof, Jens; Möritz, Constanze; Kolesnikova, Larissa
  • Virology, Vol. 287, Issue 1
  • DOI: 10.1006/viro.2001.1027

Role of VP30 Phosphorylation in the Ebola Virus Replication Cycle
journal, November 2011

  • Martinez, Miguel J.; Volchkova, Valentina A.; Raoul, Hervé
  • The Journal of Infectious Diseases, Vol. 204, Issue suppl_3
  • DOI: 10.1093/infdis/jir320

Interactions of Marburg Virus Nucleocapsid Proteins
journal, September 1998


Role of Ebola Virus VP30 in Transcription Reinitiation
journal, October 2008

  • Martinez, M. J.; Biedenkopf, N.; Volchkova, V.
  • Journal of Virology, Vol. 82, Issue 24
  • DOI: 10.1128/JVI.01395-08

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery
journal, October 2011

  • Laskowski, Roman A.; Swindells, Mark B.
  • Journal of Chemical Information and Modeling, Vol. 51, Issue 10
  • DOI: 10.1021/ci200227u

The structure of the C-terminal domain of the Zaire ebolavirus nucleoprotein
journal, August 2014

  • Dziubańska, Paulina J.; Derewenda, Urszula; Ellena, Jeffrey F.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 70, Issue 9
  • DOI: 10.1107/S1399004714014710

Crystal structure of the C-terminal domain of Ebola virus VP30 reveals a role in transcription and nucleocapsid association
journal, January 2007

  • Hartlieb, B.; Muziol, T.; Weissenhorn, W.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 2
  • DOI: 10.1073/pnas.0606730104

Filovirus replication and transcription
journal, March 2007


Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206