skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Effect of nucleoside analogue antimetabolites on the structure of PEO–PPO–PEO micelles investigated by SANS

Abstract

The effect of three nucleoside analogue antimetabolites (5-fluorouracil, floxuridine, and gemcitabine) on the structure of Pluronic L62 copolymer micelles was investigated using small-angle neutron scattering. These antimetabolites used for cancer chemotherapy have analogous molecular structures but different molecular sizes and aqueous solubilities. It was found that the addition of the three antimetabolites slightly reduced the micellar size and aggregation number, and the micellar anisotropy. The added antimetabolites also changed the internal molecular distribution of the micelles as measured by the scattering length densities, resulting in enhanced hydration of the hydrophobic core region of the micelle. The strength of the effect was found to correlate with the molecular properties of the model drugs, i.e. a larger molecular size and a higher aqueous solubility lead to enhanced hydration of the micellar core.

Authors:
; ORCiD logo; ; ORCiD logo
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1368314
Resource Type:
Journal Article
Journal Name:
Physical Chemistry Chemical Physics. PCCP (Print)
Additional Journal Information:
Journal Volume: 19; Journal Issue: 24; Journal ID: ISSN 1463-9076
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
ENGLISH
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Han, Youngkyu, Zhang, Zhe, Smith, Gregory S., and Do, Changwoo. Effect of nucleoside analogue antimetabolites on the structure of PEO–PPO–PEO micelles investigated by SANS. United States: N. p., 2017. Web. doi:10.1039/C7CP02028G.
Han, Youngkyu, Zhang, Zhe, Smith, Gregory S., & Do, Changwoo. Effect of nucleoside analogue antimetabolites on the structure of PEO–PPO–PEO micelles investigated by SANS. United States. doi:10.1039/C7CP02028G.
Han, Youngkyu, Zhang, Zhe, Smith, Gregory S., and Do, Changwoo. Sun . "Effect of nucleoside analogue antimetabolites on the structure of PEO–PPO–PEO micelles investigated by SANS". United States. doi:10.1039/C7CP02028G.
@article{osti_1368314,
title = {Effect of nucleoside analogue antimetabolites on the structure of PEO–PPO–PEO micelles investigated by SANS},
author = {Han, Youngkyu and Zhang, Zhe and Smith, Gregory S. and Do, Changwoo},
abstractNote = {The effect of three nucleoside analogue antimetabolites (5-fluorouracil, floxuridine, and gemcitabine) on the structure of Pluronic L62 copolymer micelles was investigated using small-angle neutron scattering. These antimetabolites used for cancer chemotherapy have analogous molecular structures but different molecular sizes and aqueous solubilities. It was found that the addition of the three antimetabolites slightly reduced the micellar size and aggregation number, and the micellar anisotropy. The added antimetabolites also changed the internal molecular distribution of the micelles as measured by the scattering length densities, resulting in enhanced hydration of the hydrophobic core region of the micelle. The strength of the effect was found to correlate with the molecular properties of the model drugs, i.e. a larger molecular size and a higher aqueous solubility lead to enhanced hydration of the micellar core.},
doi = {10.1039/C7CP02028G},
journal = {Physical Chemistry Chemical Physics. PCCP (Print)},
issn = {1463-9076},
number = 24,
volume = 19,
place = {United States},
year = {2017},
month = {1}
}

Works referenced in this record:

Delivering nanomedicine to solid tumors
journal, September 2010

  • Jain, Rakesh K.; Stylianopoulos, Triantafyllos
  • Nature Reviews Clinical Oncology, Vol. 7, Issue 11
  • DOI: 10.1038/nrclinonc.2010.139

Recent advances with liposomes as pharmaceutical carriers
journal, February 2005

  • Torchilin, Vladimir P.
  • Nature Reviews Drug Discovery, Vol. 4, Issue 2
  • DOI: 10.1038/nrd1632

Microcalorimetric detection of lower critical solution temperatures in aqueous polymer solutions
journal, May 1990

  • Schild, Howard G.; Tirrell, David A.
  • The Journal of Physical Chemistry, Vol. 94, Issue 10
  • DOI: 10.1021/j100373a088

Poly(ethylene oxide)-block-poly(l-amino acid) micelles for drug delivery
journal, February 2002


Pluronic Triblock Copolymer Systems and Their Interactions with Ibuprofen
journal, June 2009

  • Foster, Beth; Cosgrove, Terence; Hammouda, Boualem
  • Langmuir, Vol. 25, Issue 12
  • DOI: 10.1021/la900298m

Thermoreversible Morphology and Conductivity of a Conjugated Polymer Network Embedded in Block Copolymer Self-Assemblies
journal, July 2016


Analysis of small angle neutron scattering spectra from polydisperse interacting colloids
journal, September 1983

  • Kotlarchyk, Michael; Chen, Sow‐Hsin
  • The Journal of Chemical Physics, Vol. 79, Issue 5
  • DOI: 10.1063/1.446055

The effect of pharmaceuticals on the nanoscale structure of PEO–PPO–PEO micelles
journal, January 2008

  • Sharma, Praveen K.; Reilly, Meghan J.; Jones, Deanna N.
  • Colloids and Surfaces B: Biointerfaces, Vol. 61, Issue 1
  • DOI: 10.1016/j.colsurfb.2007.07.002

Long-circulating gadolinium-encapsulated liposomes for potential application in tumor neutron capture therapy
journal, April 2006


SANS study on self-assembled structures of Pluronic F127 triblock copolymer induced by additives and temperature
journal, December 2013

  • Kim, Tae-Hwan; Han, Young-Soo; Jang, Jong-Dae
  • Journal of Applied Crystallography, Vol. 47, Issue 1
  • DOI: 10.1107/S1600576713030094

Small-Angle Neutron Scattering Analysis of the Structure and Interaction of Triblock Copolymer Micelles in Aqueous Solution
journal, April 1998

  • Liu, Yingchun; Chen, Sow-Hsin; Huang, John S.
  • Macromolecules, Vol. 31, Issue 7
  • DOI: 10.1021/ma971253o

Multifunctional Micellar Nanomedicine for Cancer Therapy
journal, February 2009

  • Blanco, Elvin; Kessinger, Chase W.; Sumer, Baran D.
  • Experimental Biology and Medicine, Vol. 234, Issue 2
  • DOI: 10.3181/0808-MR-250

Effect of anti-inflammatories on Pluronic® F127: micellar assembly, gelation and partitioning
journal, July 2004


Molecular-weight Determination by Light Scattering.
journal, January 1947

  • Debye, P.
  • The Journal of Physical and Colloid Chemistry, Vol. 51, Issue 1
  • DOI: 10.1021/j150451a002

Structure and Resistivity of Liquid Metals
journal, May 1966


Well Ordered Polymer Melts from Blends of Disordered Triblock Copolymer Surfactants and Functional Homopolymers
journal, May 2008

  • Tirumala, Vijay R.; Romang, Alvin; Agarwal, Sumit
  • Advanced Materials, Vol. 20, Issue 9
  • DOI: 10.1002/adma.200701577

Growth and Shrinkage of Pluronic Micelles by Uptake and Release of Flurbiprofen: Variation of pH
journal, April 2012

  • Alexander, Shirin; de Vos, Wiebe M.; Castle, Thomas C.
  • Langmuir, Vol. 28, Issue 16
  • DOI: 10.1021/la204262w

Properties of aqueous salt solutions of poly(ethylene oxide). Cloud points, ? temperatures
journal, January 1987


Effect of Temperature, Cosolvent, and Added Drug on Pluronic–Flurbiprofen Micellization
journal, September 2012

  • Alexander, Shirin; Cosgrove, Terence; Castle, Thomas C.
  • The Journal of Physical Chemistry B, Vol. 116, Issue 37
  • DOI: 10.1021/jp303185m

The dawning era of polymer therapeutics
journal, May 2003

  • Duncan, Ruth
  • Nature Reviews Drug Discovery, Vol. 2, Issue 5, p. 347-360
  • DOI: 10.1038/nrd1088

Cancer nanotechnology: opportunities and challenges
journal, March 2005

  • Ferrari, Mauro
  • Nature Reviews Cancer, Vol. 5, Issue 3, p. 161-171
  • DOI: 10.1038/nrc1566

Poly(ethylene oxide)poly(propylene oxide)poly(ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling
journal, March 1995

  • Alexandridis, Paschalis; Alan Hatton, T.
  • Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 96, Issue 1-2
  • DOI: 10.1016/0927-7757(94)03028-X

Structure of (Deuterated PEO)−(PPO)−(Deuterated PEO) Block Copolymer Micelles As Determined by Small Angle Neutron Scattering
journal, March 1999

  • Goldmints, Isabella; Yu, Ga-er; Booth, Colin
  • Langmuir, Vol. 15, Issue 5
  • DOI: 10.1021/la9807006

Solubilisation of model adjuvants by Pluronic block copolymers
journal, April 2010

  • Sharp, Melissa A.; Washington, Clive; Cosgrove, Terence
  • Journal of Colloid and Interface Science, Vol. 344, Issue 2
  • DOI: 10.1016/j.jcis.2010.01.005

Anomalous clouding behavior of an ethylene oxide–propylene oxide block copolymer in aqueous solution
journal, February 2002

  • Desai, P. R.; Jain, N. J.; Bahadur, P.
  • Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 197, Issue 1-3
  • DOI: 10.1016/S0927-7757(01)00801-9

Nanocarriers as an emerging platform for cancer therapy
journal, December 2007

  • Peer, Dan; Karp, Jeffrey M.; Hong, Seungpyo
  • Nature Nanotechnology, Vol. 2, Issue 12
  • DOI: 10.1038/nnano.2007.387

Bimodal Paramagnetic and Fluorescent Liposomes for Cellular and Tumor Magnetic Resonance Imaging
journal, January 2008

  • Kamaly, Nazila; Kalber, Tammy; Ahmad, Ayesha
  • Bioconjugate Chemistry, Vol. 19, Issue 1
  • DOI: 10.1021/bc7001715

Microemulsion-based media as novel drug delivery systems
journal, December 2012


Poly(ethylene oxide)–poly(propylene oxide) block copolymer micelles as drug delivery agents: Improved hydrosolubility, stability and bioavailability of drugs
journal, June 2007

  • Chiappetta, Diego A.; Sosnik, Alejandro
  • European Journal of Pharmaceutics and Biopharmaceutics, Vol. 66, Issue 3
  • DOI: 10.1016/j.ejpb.2007.03.022

Micelles from PEO–PPO–PEO block copolymers as nanocontainers for solubilization of a poorly water soluble drug hydrochlorothiazide
journal, March 2011


Interaction, critical, percolation and kinetic glass transitions in pluronic L-64 micellar solutions
journal, July 2001