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Title: Harnessing catalytic pumps for directional delivery of microparticles in microchambers

Abstract

The directed transport of microparticles in microfluidic devices is vital for efficient bioassays and fabrication of complex microstructures. There remains, but, a need for methods to propel and steer microscopic cargo that do not require modifying these particles. By using theory and experiments, we show that catalytic surface reactions can be used to deliver microparticle cargo to specified regions in microchambers. Here reagents diffuse from a gel reservoir and react with the catalyst-coated surface. Fluid density gradients due to the spatially varying reagent concentration induce a convective flow, which carries the suspended particles until the reagents are consumed. Consequently, the cargo is deposited around a specific position on the surface. The velocity and final peak location of the cargo can be tuned independently. And by increasing the local particle concentration, highly sensitive assays can be performed efficiently and rapidly. Moreover, the process can be repeated by introducing fresh reagent into the microchamber.

Authors:
 [1];  [2];  [1]; ORCiD logo [2];  [1];  [1];  [1];  [2];  [1]
  1. Pennsylvania State Univ., University Park, PA (United States). Dept. of Chemistry
  2. Univ. of Pittsburgh, PA (United States). Dept. of Chemical Engineering
Publication Date:
Research Org.:
Univ. of Pittsburgh, PA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1366471
Grant/Contract Number:
FG02-90ER45438
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 8; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS; chemical engineering; fluid dynamics

Citation Formats

Das, Sambeeta, Shklyaev, Oleg E., Altemose, Alicia, Shum, Henry, Ortiz-Rivera, Isamar, Valdez, Lyanne, Mallouk, Thomas E., Balazs, Anna C., and Sen, Ayusman. Harnessing catalytic pumps for directional delivery of microparticles in microchambers. United States: N. p., 2017. Web. doi:10.1038/ncomms14384.
Das, Sambeeta, Shklyaev, Oleg E., Altemose, Alicia, Shum, Henry, Ortiz-Rivera, Isamar, Valdez, Lyanne, Mallouk, Thomas E., Balazs, Anna C., & Sen, Ayusman. Harnessing catalytic pumps for directional delivery of microparticles in microchambers. United States. doi:10.1038/ncomms14384.
Das, Sambeeta, Shklyaev, Oleg E., Altemose, Alicia, Shum, Henry, Ortiz-Rivera, Isamar, Valdez, Lyanne, Mallouk, Thomas E., Balazs, Anna C., and Sen, Ayusman. Fri . "Harnessing catalytic pumps for directional delivery of microparticles in microchambers". United States. doi:10.1038/ncomms14384. https://www.osti.gov/servlets/purl/1366471.
@article{osti_1366471,
title = {Harnessing catalytic pumps for directional delivery of microparticles in microchambers},
author = {Das, Sambeeta and Shklyaev, Oleg E. and Altemose, Alicia and Shum, Henry and Ortiz-Rivera, Isamar and Valdez, Lyanne and Mallouk, Thomas E. and Balazs, Anna C. and Sen, Ayusman},
abstractNote = {The directed transport of microparticles in microfluidic devices is vital for efficient bioassays and fabrication of complex microstructures. There remains, but, a need for methods to propel and steer microscopic cargo that do not require modifying these particles. By using theory and experiments, we show that catalytic surface reactions can be used to deliver microparticle cargo to specified regions in microchambers. Here reagents diffuse from a gel reservoir and react with the catalyst-coated surface. Fluid density gradients due to the spatially varying reagent concentration induce a convective flow, which carries the suspended particles until the reagents are consumed. Consequently, the cargo is deposited around a specific position on the surface. The velocity and final peak location of the cargo can be tuned independently. And by increasing the local particle concentration, highly sensitive assays can be performed efficiently and rapidly. Moreover, the process can be repeated by introducing fresh reagent into the microchamber.},
doi = {10.1038/ncomms14384},
journal = {Nature Communications},
number = ,
volume = 8,
place = {United States},
year = {Fri Feb 17 00:00:00 EST 2017},
month = {Fri Feb 17 00:00:00 EST 2017}
}

Journal Article:
Free Publicly Available Full Text
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Cited by: 1work
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