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Title: Effect of Defects and Cellular Patterning on Microtubule Dynamics.

Abstract

Abstract not provided.

Authors:
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1365499
Report Number(s):
SAND2017-3871T
652444
DOE Contract Number:
AC04-94AL85000
Resource Type:
Thesis/Dissertation
Country of Publication:
United States
Language:
English

Citation Formats

Martinez, Haneen. Effect of Defects and Cellular Patterning on Microtubule Dynamics.. United States: N. p., 2017. Web.
Martinez, Haneen. Effect of Defects and Cellular Patterning on Microtubule Dynamics.. United States.
Martinez, Haneen. Sat . "Effect of Defects and Cellular Patterning on Microtubule Dynamics.". United States. doi:.
@article{osti_1365499,
title = {Effect of Defects and Cellular Patterning on Microtubule Dynamics.},
author = {Martinez, Haneen},
abstractNote = {Abstract not provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Apr 01 00:00:00 EDT 2017},
month = {Sat Apr 01 00:00:00 EDT 2017}
}

Thesis/Dissertation:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that hold this thesis or dissertation.

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  • Abstract not provided.
  • In recent years, an in vitro system for the culturing of hematopoietic stem cells and precursor cells over extended time periods has been developed. It has been clearly demonstrated that these cultures are supporting ongoing hematopoiesis, which makes them an ideal model system for investigating questions relating to both normal and abnormal hematopoiesis. The most easily measured aspect of this culture system is its ongoing production of hematopoietic cells which are recoverable at weekly culture feedings. The current study develops a mathematical model of the production of cells in these cultures and then applies that model in the form ofmore » a computer simulation to several experimental protocols, particularly those involving the exposure of the culture system to ionizing radiation. Extensive experimental testing is described, which verifies the validity of the mathematical description presented, and further supports the hypothesis of a radiation insensitive hematopoietic microenvironment.« less
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