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Title: Enhanced processive cellulases

Abstract

Nucleic acid sequences encoding chimeric polypeptides that exhibit enhanced cellulase activities are disclosed herein. These nucleic acids may be expressed in hosts such as fungi, which in turn may be cultured to produce chimeric polypeptides. Also disclosed are chimeric polypeptides and their use in the degradation of cellulosic materials.

Inventors:
; ; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
National Renewable Energy Lab. (NREL), Golden, CO (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1364629
Patent Number(s):
9,683,248
Application Number:
14/365,200
Assignee:
Alliance for Sustainable Energy, LLC NREL
DOE Contract Number:  
AC36-08G028308
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Dec 17
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Adney, William S., Beckham, Gregg T., Jarvis, Eric, Himmel, Michael E., Decker, Stephen R., Linger, Jeffrey G., Podkaminer, Kara, Baker, John O., Taylor, II, Larry, Xu, Qi, and Singh, Arjun. Enhanced processive cellulases. United States: N. p., 2017. Web.
Adney, William S., Beckham, Gregg T., Jarvis, Eric, Himmel, Michael E., Decker, Stephen R., Linger, Jeffrey G., Podkaminer, Kara, Baker, John O., Taylor, II, Larry, Xu, Qi, & Singh, Arjun. Enhanced processive cellulases. United States.
Adney, William S., Beckham, Gregg T., Jarvis, Eric, Himmel, Michael E., Decker, Stephen R., Linger, Jeffrey G., Podkaminer, Kara, Baker, John O., Taylor, II, Larry, Xu, Qi, and Singh, Arjun. Tue . "Enhanced processive cellulases". United States. doi:. https://www.osti.gov/servlets/purl/1364629.
@article{osti_1364629,
title = {Enhanced processive cellulases},
author = {Adney, William S. and Beckham, Gregg T. and Jarvis, Eric and Himmel, Michael E. and Decker, Stephen R. and Linger, Jeffrey G. and Podkaminer, Kara and Baker, John O. and Taylor, II, Larry and Xu, Qi and Singh, Arjun},
abstractNote = {Nucleic acid sequences encoding chimeric polypeptides that exhibit enhanced cellulase activities are disclosed herein. These nucleic acids may be expressed in hosts such as fungi, which in turn may be cultured to produce chimeric polypeptides. Also disclosed are chimeric polypeptides and their use in the degradation of cellulosic materials.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 20 00:00:00 EDT 2017},
month = {Tue Jun 20 00:00:00 EDT 2017}
}

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Works referenced in this record:

A family of thermostable fungal cellulases created by structure-guided recombination
journal, March 2009

  • Heinzelman, P.; Snow, C. D.; Wu, I.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 14, p. 5610-5615
  • DOI: 10.1073/pnas.0901417106

SCHEMA Recombination of a Fungal Cellulase Uncovers a Single Mutation That Contributes Markedly to Stability
journal, July 2009

  • Heinzelman, Pete; Snow, Christopher D.; Smith, Matthew A.
  • Journal of Biological Chemistry, Vol. 284, Issue 39, p. 26229-26233
  • DOI: 10.1074/jbc.C109.034058

Binding modules alter the activity of chimeric cellulases: Effects of biomass pretreatment and enzyme source
journal, July 2010

  • Kim, Tae-Wan; Chokhawala, Harshal A.; Nadler, Dana
  • Biotechnology and Bioengineering, Vol. 107, Issue 4, p. 601-611
  • DOI: 10.1002/bit.22856