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Title: A brief overview of compartmental modeling for intake of plutonium via wounds

Abstract

Here, the aim of this study is to present several approaches that have been used to model the behavior of radioactive materials (specifically Pu) in contaminated wounds. We also review some attempts by the health physics community to validate and revise the National Council on Radiation Protection and Measurements (NCRP) 156 biokinetic model for wounds, and present some general recommendations based on the review. Modeling of intake via the wound pathway is complicated because of a large array of wound characteristics (e.g. solubility and chemistry of the material, type and depth of the tissue injury, anatomical location of injury). Moreover, because a majority of the documented wound cases in humans are medically treated (excised or treated with chelation), the data to develop biokinetic models for unperturbed wound exposures are limited. Since the NCRP wound model was largely developed from animal data, it is important to continue to validate and improve the model using human data whenever plausible.

Authors:
 [1];  [1];  [1];  [1];  [2]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  2. Ray Guilmette and Assoc., Perry, ME (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1364555
Report Number(s):
LA-UR-17-22480
Journal ID: ISSN 0144-8420
Grant/Contract Number:
AC52-06NA25396
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Radiation Protection Dosimetry
Additional Journal Information:
Journal Volume: 178; Journal Issue: 1; Journal ID: ISSN 0144-8420
Publisher:
Oxford University Press
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; radiation protection

Citation Formats

Poudel, Deepesh, Klumpp, John Allan, Waters, Tom L., Bertelli, Luiz, and Guilmette, Raymond A. A brief overview of compartmental modeling for intake of plutonium via wounds. United States: N. p., 2017. Web. doi:10.1093/rpd/ncx071.
Poudel, Deepesh, Klumpp, John Allan, Waters, Tom L., Bertelli, Luiz, & Guilmette, Raymond A. A brief overview of compartmental modeling for intake of plutonium via wounds. United States. doi:10.1093/rpd/ncx071.
Poudel, Deepesh, Klumpp, John Allan, Waters, Tom L., Bertelli, Luiz, and Guilmette, Raymond A. Wed . "A brief overview of compartmental modeling for intake of plutonium via wounds". United States. doi:10.1093/rpd/ncx071. https://www.osti.gov/servlets/purl/1364555.
@article{osti_1364555,
title = {A brief overview of compartmental modeling for intake of plutonium via wounds},
author = {Poudel, Deepesh and Klumpp, John Allan and Waters, Tom L. and Bertelli, Luiz and Guilmette, Raymond A.},
abstractNote = {Here, the aim of this study is to present several approaches that have been used to model the behavior of radioactive materials (specifically Pu) in contaminated wounds. We also review some attempts by the health physics community to validate and revise the National Council on Radiation Protection and Measurements (NCRP) 156 biokinetic model for wounds, and present some general recommendations based on the review. Modeling of intake via the wound pathway is complicated because of a large array of wound characteristics (e.g. solubility and chemistry of the material, type and depth of the tissue injury, anatomical location of injury). Moreover, because a majority of the documented wound cases in humans are medically treated (excised or treated with chelation), the data to develop biokinetic models for unperturbed wound exposures are limited. Since the NCRP wound model was largely developed from animal data, it is important to continue to validate and improve the model using human data whenever plausible.},
doi = {10.1093/rpd/ncx071},
journal = {Radiation Protection Dosimetry},
number = 1,
volume = 178,
place = {United States},
year = {Wed Jun 07 00:00:00 EDT 2017},
month = {Wed Jun 07 00:00:00 EDT 2017}
}

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Free Publicly Available Full Text
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