skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Substituted from epoxides


Catalysts and methods for the carbonylation of epoxides to substituted and .beta.-lactones are disclosed.

Publication Date:
Research Org.:
Cornell Univ., Ithaca, NY (United States)
Sponsoring Org.:
OSTI Identifier:
Patent Number(s):
Application Number:
Cornell University CHO
DOE Contract Number:  
Resource Type:
Resource Relation:
Patent File Date: 2013 Sep 04
Country of Publication:
United States

Citation Formats

Coates, Geoffrey W., and Kramer, John W.. Substituted from epoxides. United States: N. p., 2017. Web.
Coates, Geoffrey W., & Kramer, John W.. Substituted from epoxides. United States.
Coates, Geoffrey W., and Kramer, John W.. Wed . "Substituted from epoxides". United States. doi:.
title = {Substituted from epoxides},
author = {Coates, Geoffrey W. and Kramer, John W.},
abstractNote = {Catalysts and methods for the carbonylation of epoxides to substituted and .beta.-lactones are disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Jun 14 00:00:00 EDT 2017},
month = {Wed Jun 14 00:00:00 EDT 2017}


Save / Share:

Works referenced in this record:

Catalytic Synthesis of β3-Amino Acid Derivatives from α-Amino Acids
journal, May 2008

  • Byrne, Christopher M.; Church, Tamara L.; Kramer, John W.
  • Angewandte Chemie International Edition, Vol. 47, Issue 21, p. 3979-3983
  • DOI: 10.1002/anie.200705310

Enantioselective Synthesis of Unsaturated Cyclic Tertiary Ethers By Mo-Catalyzed Olefin Metathesis
journal, April 2001

  • Cefalo, Dustin R.; Kiely, Andrew F.; Wuchrer, Margarita
  • Journal of the American Chemical Society, Vol. 123, Issue 13, p. 3139-3140
  • DOI: 10.1021/ja0039177

Catalytic Carbonylation of β-Lactones to Succinic Anhydrides
journal, June 2004

  • Getzler, Yutan D. Y. L.; Kundnani, Vinod; Lobkovsky, Emil B.
  • Journal of the American Chemical Society, Vol. 126, Issue 22, p. 6842-6843
  • DOI: 10.1021/ja048946m

Synthesis of β-Lactones:  A Highly Active and Selective Catalyst for Epoxide Carbonylation
journal, February 2002

  • Getzler, Yutan D. Y. L.; Mahadevan, Viswanath; Lobkovsky, Emil B.
  • Journal of the American Chemical Society, Vol. 124, Issue 7, p. 1174-1175
  • DOI: 10.1021/ja017434u

Asymmetric Catalysis Special Feature Part II: Development of an efficient, scalable, aldolase-catalyzed process for enantioselective synthesis of statin intermediates
journal, April 2004

  • Greenberg, W. A.; Varvak, A.; Hanson, S. R.
  • Proceedings of the National Academy of Sciences, Vol. 101, Issue 16, p. 5788-5793
  • DOI: 10.1073/pnas.0307563101

Carbonylation of Epoxides to Substituted 3-Hydroxy-δ-Lactones
journal, December 2007

  • Kramer, John W.; Joh, Daniel Y.; Coates, Geoffrey W.
  • Organic Letters, Vol. 9, Issue 26, p. 5581-5583
  • DOI: 10.1021/ol702475e

Assembly intermediates in polyketide biosynthesis: enantioselective syntheses of β-hydroxycarbonyl compounds
journal, January 2005

  • Le Sann, Christine; Muñoz, Dulce M.; Saunders, Natalie
  • Organic & Biomolecular Chemistry, Vol. 3, Issue 9, 1719-1728
  • DOI: 10.1039/B419492F

Regioselective Hydroformylation of Allylic Alcohols
journal, May 2011

  • Lightburn, Thomas E.; De Paolis, Omar A.; Cheng, Ka H.
  • Organic Letters, Vol. 13, Issue 10, p. 2686-2689
  • DOI: 10.1021/ol200782d

Dimethyldioxirane reactions: Rate acceleration due to intramolecular H-bonding
journal, November 1996

Catalytic Double Carbonylation of Epoxides to Succinic Anhydrides:  Catalyst Discovery, Reaction Scope, and Mechanism
journal, April 2007

  • Rowley, John M.; Lobkovsky, Emil B.; Coates, Geoffrey W.
  • Journal of the American Chemical Society, Vol. 129, Issue 16, p. 4948-4960
  • DOI: 10.1021/ja066901a

A Readily Synthesized and Highly Active Epoxide Carbonylation Catalyst Based on a Chromium Porphyrin Framework:  Expanding the Range of Available β-Lactones
journal, February 2004

  • Schmidt, Joseph A. R.; Mahadevan, Viswanath; Getzler, Yutan D. Y. L.
  • Organic Letters, Vol. 6, Issue 3, p. 373-376
  • DOI: 10.1021/ol036244g

Highly Selective Hydrolytic Kinetic Resolution of Terminal Epoxides Catalyzed by Chiral (salen)Co III Complexes. Practical Synthesis of Enantioenriched Terminal Epoxides and 1,2-Diols
journal, February 2002

  • Schaus, Scott E.; Brandes, Bridget D.; Larrow, Jay F.
  • Journal of the American Chemical Society, Vol. 124, Issue 7, p. 1307-1315
  • DOI: 10.1021/ja016737l

Enzymatic Lactonization Stategy for Enantioselective Synthesis of a Tetrahydrolipstatin Synthon
October 1999

  • Sharma, A.; Chattopadhyay, S.
  • J. Org. Chem., Vol. 64, Issue 22, p. 8059-8062
  • DOI: 10.1021/jo990370+

Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors
journal, July 2003

  • Tobert, Jonathan A.
  • Nature Reviews Drug Discovery, Vol. 2, Issue 7, p. 517-526
  • DOI: 10.1038/nrd1112

Parallel Synthesis of a Vitamin D 3 Library in the Solid-Phase
journal, April 2001

  • Hijikuro, Ichiro; Doi, Takayuki; Takahashi, Takashi
  • Journal of the American Chemical Society, Vol. 123, Issue 16, p. 3716-3722
  • DOI: 10.1021/ja003976k

Synthesis of syn - and anti -3,5-Dihydroxy-6-heptenoates from 2-Deoxy- d -ribose: Intermediates for Polyols Synthesis
journal, January 2003