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Title: Chitosan-Gated Magnetic-Responsive Nanocarrier for Dual-Modal Optical Imaging, Switchable Drug Release, and Synergistic Therapy

Abstract

In this study, we present a multifunctional yet structurally simple nanocarrier that has a high drug loading capacity, releases drug in response to onset of an AC magnetic field, and can serve as a long-term imaging contrast agent and effectively kills cancer cells by synergistic action. This nanocarrier (HMMC-NC) has a spherical shell structure with a center cavity of 80 nm in diameter. The shell is comprised of two layers: an inner layer of magnetite that exhibits superparamagnetism and an outer layer of mesoporous carbon embedded with carbon dots that exhibit photoluminescence property. Thus in addition to being a drug carrier, HMMC-NC is also a contrast agent for bioimaging. The switchable drug release is enabled by the chitosan molecules attached on the nanocarrier as the switching material which turns on or off the drug release in response to the application or withdrawal of an AC magnetic field.

Authors:
 [1];  [1];  [1];  [1];  [1];  [2];  [3];  [1]
  1. Department of Materials Science and Engineering, University of Washington, Seattle WA 98195 USA
  2. Department of Materials Science and Engineering, University of Washington, Seattle WA 98195 USA; Fundamental and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland WA 99354 USA
  3. Department of Chemistry, The College of Staten Island, City University of New York, Staten Island NY 10314 USA
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1361983
Report Number(s):
PNNL-SA-126395
Journal ID: ISSN 2192-2640
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Advanced Healthcare Materials; Journal Volume: 6; Journal Issue: 6
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 60 APPLIED LIFE SCIENCES

Citation Formats

Wang, Hui, Mu, Qingxin, Revia, Richard, Wang, Kui, Zhou, Xuezhe, Pauzauskie, Peter J., Zhou, Shuiqin, and Zhang, Miqin. Chitosan-Gated Magnetic-Responsive Nanocarrier for Dual-Modal Optical Imaging, Switchable Drug Release, and Synergistic Therapy. United States: N. p., 2017. Web. doi:10.1002/adhm.201601080.
Wang, Hui, Mu, Qingxin, Revia, Richard, Wang, Kui, Zhou, Xuezhe, Pauzauskie, Peter J., Zhou, Shuiqin, & Zhang, Miqin. Chitosan-Gated Magnetic-Responsive Nanocarrier for Dual-Modal Optical Imaging, Switchable Drug Release, and Synergistic Therapy. United States. doi:10.1002/adhm.201601080.
Wang, Hui, Mu, Qingxin, Revia, Richard, Wang, Kui, Zhou, Xuezhe, Pauzauskie, Peter J., Zhou, Shuiqin, and Zhang, Miqin. Wed . "Chitosan-Gated Magnetic-Responsive Nanocarrier for Dual-Modal Optical Imaging, Switchable Drug Release, and Synergistic Therapy". United States. doi:10.1002/adhm.201601080.
@article{osti_1361983,
title = {Chitosan-Gated Magnetic-Responsive Nanocarrier for Dual-Modal Optical Imaging, Switchable Drug Release, and Synergistic Therapy},
author = {Wang, Hui and Mu, Qingxin and Revia, Richard and Wang, Kui and Zhou, Xuezhe and Pauzauskie, Peter J. and Zhou, Shuiqin and Zhang, Miqin},
abstractNote = {In this study, we present a multifunctional yet structurally simple nanocarrier that has a high drug loading capacity, releases drug in response to onset of an AC magnetic field, and can serve as a long-term imaging contrast agent and effectively kills cancer cells by synergistic action. This nanocarrier (HMMC-NC) has a spherical shell structure with a center cavity of 80 nm in diameter. The shell is comprised of two layers: an inner layer of magnetite that exhibits superparamagnetism and an outer layer of mesoporous carbon embedded with carbon dots that exhibit photoluminescence property. Thus in addition to being a drug carrier, HMMC-NC is also a contrast agent for bioimaging. The switchable drug release is enabled by the chitosan molecules attached on the nanocarrier as the switching material which turns on or off the drug release in response to the application or withdrawal of an AC magnetic field.},
doi = {10.1002/adhm.201601080},
journal = {Advanced Healthcare Materials},
number = 6,
volume = 6,
place = {United States},
year = {Wed Jan 25 00:00:00 EST 2017},
month = {Wed Jan 25 00:00:00 EST 2017}
}