Profiling microbial lignocellulose degradation and utilization by emergent omics technologies

Rosnow, Joshua J.; Anderson, Lindsey N.; Nair, Reji N.; Baker, Erin S.; Wright, Aaron T.

doi:10.1080/07388551.2016.1209158

Title: Profiling microbial lignocellulose degradation and utilization by emergent omics technologies

Journal Article · Wed Jul 20 00:00:00 EDT 2016 · CRC Critical Reviews in Biotechnology

DOI:https://doi.org/10.1080/07388551.2016.1209158· OSTI ID:1361978

Rosnow, Joshua J. ^[1]; Anderson, Lindsey N. ^[1]; Nair, Reji N. ^[1]; Baker, Erin S. ^[1]; Wright, Aaron T. ^[1]

Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA

The use of plant materials to generate renewable biofuels and other high-value chemicals is the sustainable and preferable option, but will require considerable improvements to increase the rate and efficiency of lignocellulose depolymerization. This review highlights novel and emergent technologies that are being developed and deployed to characterize the process of lignocellulose degradation. The review will also illustrate how microbial communities deconstruct and metabolize lignocellulose by identifying the necessary genes and enzyme activities along with the reaction products. These technologies include multi-omic measurements, cell sorting and isolation, nuclear magnetic resonance spectroscopy (NMR), activity-based protein profiling, and direct measurement of enzyme activity. The recalcitrant nature of lignocellulose necessitates the need to characterize the methods microbes employ to deconstruct lignocellulose to inform new strategies on how to greatly improve biofuel conversion processes. New technologies are yielding important insights into microbial functions and strategies employed to degrade lignocellulose, providing a mechanistic blueprint to advance biofuel production.

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Research Organization:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

OSTI ID:: 1361978

Report Number(s):: PNNL-SA-116817; 48680; KP1601010

Journal Information:: CRC Critical Reviews in Biotechnology, Vol. 37, Issue 5; ISSN 0738-8551

Country of Publication:: United States

Language:: English

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