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Title: Positive modulator of bone morphogenic protein-2

Patent ·
OSTI ID:1361549
; ; ;

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
ACO2-98CH1086
Assignee:
Brookhaven Science Associates, LLC
Patent Number(s):
9,670,258
Application Number:
15/240,977
OSTI ID:
1361549
Resource Relation:
Patent File Date: 2016 Aug 18
Country of Publication:
United States
Language:
English

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