skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Ultrasensitive biochemical sensing device and method of sensing analytes

Abstract

Systems and methods biochemically sense a concentration of a ligand using a sensor having a substrate having a metallic nanoparticle array formed onto a surface of the substrate. A light source is incident on the surface. A matrix is deposited over the nanoparticle array and contains a protein adapted to binding the ligand. A detector detects s-polarized and p-polarized light from the reflective surface. Spacing of nanoparticles in the array and wavelength of light are selected such that plasmon resonance occurs with an isotropic point such that -s and -p polarizations of the incident light result in substantially identical surface Plasmon resonance, wherein binding of the ligand to the protein shifts the resonance such that differences between the -S and -P polarizations give in a signal indicative of presence of the ligand.

Inventors:
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1361542
Patent Number(s):
9,671,327
Application Number:
13/422,718
Assignee:
The Regents of the University of Colorado, A Body Corporate ANL
DOE Contract Number:  
AC02-06CH11357
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Mar 16
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Pinchuk, Anatoliy. Ultrasensitive biochemical sensing device and method of sensing analytes. United States: N. p., 2017. Web.
Pinchuk, Anatoliy. Ultrasensitive biochemical sensing device and method of sensing analytes. United States.
Pinchuk, Anatoliy. Tue . "Ultrasensitive biochemical sensing device and method of sensing analytes". United States. doi:. https://www.osti.gov/servlets/purl/1361542.
@article{osti_1361542,
title = {Ultrasensitive biochemical sensing device and method of sensing analytes},
author = {Pinchuk, Anatoliy},
abstractNote = {Systems and methods biochemically sense a concentration of a ligand using a sensor having a substrate having a metallic nanoparticle array formed onto a surface of the substrate. A light source is incident on the surface. A matrix is deposited over the nanoparticle array and contains a protein adapted to binding the ligand. A detector detects s-polarized and p-polarized light from the reflective surface. Spacing of nanoparticles in the array and wavelength of light are selected such that plasmon resonance occurs with an isotropic point such that -s and -p polarizations of the incident light result in substantially identical surface Plasmon resonance, wherein binding of the ligand to the protein shifts the resonance such that differences between the -S and -P polarizations give in a signal indicative of presence of the ligand.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 06 00:00:00 EDT 2017},
month = {Tue Jun 06 00:00:00 EDT 2017}
}

Patent:

Save / Share: