Lack of association between obsessive-compulsive disorder and the dopamine D{sub 3} receptor gene: Some preliminary considerations

Journal Article · Thu Sep 15 00:00:00 EDT 1994 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320540312· OSTI ID:135921

Catalano, M; Sciuto, G; Di Bella, D ^[1]

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1. Univ. of Milan Medical School (Italy); and others

Controversial results possibly suggesting an association between Tourette`s syndrome (TS) and excess of homozygosity at an Msc I polymorphism in the Dopamine D{sub 3} receptor (DRD{sub 3}) gene have recently been reported. Since a relationship between obsessive-compulsive disorder (OCD) and Tourette`s syndrome (TS) has been suggested, in this study we assessed the frequency of this 2-allele polymorphism in a sample of 97 OCD patients and in 97 control subjects. No statistically significant differences in allele or genotype frequencies were found. Thus this mutation in the coding sequence of the DRD{sub 3} gene is unlikely to confer susceptibility to OCD. 28 refs., 21 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 135921
• Journal Information: American Journal of Medical Genetics, Vol. 54, Issue 3; Other Information: PBD: 15 Sep 1994
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
DOPAMINE
RECEPTORS
GENES
GENE MUTATIONS
MUTATION FREQUENCY
PATIENTS
BEHAVIOR
MENTAL DISORDERS
GENOTYPE
STATISTICS
ELECTROPHORESIS
POLYMERASE CHAIN REACTION