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Title: Calibration setting numbers for dose calibrators for the PET isotopes 52 Mn, 64 Cu, 76 Br, 86 Y, 89 Zr, 124 I

Authors:
; ; ; ; ; ; ;
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1358795
Grant/Contract Number:
NA0000979
Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
Applied Radiation and Isotopes
Additional Journal Information:
Journal Volume: 113; Journal Issue: C; Related Information: CHORUS Timestamp: 2017-10-03 22:15:44; Journal ID: ISSN 0969-8043
Publisher:
Elsevier
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Wooten, A. Lake, Lewis, Benjamin C., Szatkowski, Daniel J., Sultan, Deborah H., Abdin, Kinda I., Voller, Thomas F., Liu, Yongjian, and Lapi, Suzanne E. Calibration setting numbers for dose calibrators for the PET isotopes 52 Mn, 64 Cu, 76 Br, 86 Y, 89 Zr, 124 I. United Kingdom: N. p., 2016. Web. doi:10.1016/j.apradiso.2016.04.025.
Wooten, A. Lake, Lewis, Benjamin C., Szatkowski, Daniel J., Sultan, Deborah H., Abdin, Kinda I., Voller, Thomas F., Liu, Yongjian, & Lapi, Suzanne E. Calibration setting numbers for dose calibrators for the PET isotopes 52 Mn, 64 Cu, 76 Br, 86 Y, 89 Zr, 124 I. United Kingdom. doi:10.1016/j.apradiso.2016.04.025.
Wooten, A. Lake, Lewis, Benjamin C., Szatkowski, Daniel J., Sultan, Deborah H., Abdin, Kinda I., Voller, Thomas F., Liu, Yongjian, and Lapi, Suzanne E. Fri . "Calibration setting numbers for dose calibrators for the PET isotopes 52 Mn, 64 Cu, 76 Br, 86 Y, 89 Zr, 124 I". United Kingdom. doi:10.1016/j.apradiso.2016.04.025.
@article{osti_1358795,
title = {Calibration setting numbers for dose calibrators for the PET isotopes 52 Mn, 64 Cu, 76 Br, 86 Y, 89 Zr, 124 I},
author = {Wooten, A. Lake and Lewis, Benjamin C. and Szatkowski, Daniel J. and Sultan, Deborah H. and Abdin, Kinda I. and Voller, Thomas F. and Liu, Yongjian and Lapi, Suzanne E.},
abstractNote = {},
doi = {10.1016/j.apradiso.2016.04.025},
journal = {Applied Radiation and Isotopes},
number = C,
volume = 113,
place = {United Kingdom},
year = {Fri Jul 01 00:00:00 EDT 2016},
month = {Fri Jul 01 00:00:00 EDT 2016}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at 10.1016/j.apradiso.2016.04.025

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  • This proposal seeks support to increase our production of the radionuclides yttrium-86 and zirconium-89 while continuing to produce copper-64. We have the advantage that we already ship out copper-64 to some 20-25 institutions per week (over 60 different institutions total including 4 Canadian sites) and thus our group already has significant experience with producing, purifying and shipping radioactive materials. A significant portion of the funds requested supported the purchase of a new hotcell for the production of zirconium-89 and yttrium-86.
  • Painful bone metastases are palliatively treated with {beta}=emitting isotopes such as Y-90. To obtain quantitative biokinetic data of Y-90-citrate and Y-90-EDTMP (ethylenediaminetetramethylenephosphonate) the {beta}{sup +}-emitting sister isotope Y-86 (T{sub 1/2}=14.7 h, 33% {beta}{sup +}) was prepared and applied as Y-86-citrate and Y-86-EDTMP using whole-body PET measurements. Patients with multiple bone metastases of prostate cancer received about 200 MBq Y-86-citrate (n=4) or Y-86-EDTW (n=3). Dynamic scans were recorded over the liver up to 4 h after injection (p.i.) followed by 3 to 5 quantitative whole-body PET scans from 4 to 72 h p.i. The reconstructed transversal PET images were evaluated tomore » obtain time-activity curves in normal bone, metastases and liver. Based on these Y-86-uptake kinetics data the radiation doses caused by the Y-90-compounds were calculated. Whereas Y-86-citrate was found in the liver (14% at 4 h p.i.), this organ was not visible after the injection of Y-86-EDTMP. For both compounds 20% to 40% of the injected activity was found in the skeleton. Maximum ratios of activity concentration of metastasis to normal bone reached 9:1 for citrate and 15:1 for EDTMP. The dose to the red marrow was 2.6{plus_minus}0.4 mGy per 1 MBq of injected Y-90-citrate and 1.7{plus_minus}0.3 mGy for Y-90-EDTMP. The doses delivered to the metastases varied from 9 to 39 mGy per 1 MBq of the injected Y-90-activity. This study shows that Y-86 and PET allow to compare the pharmo-kinetics of different Y-90-radiotherapeuticals quantitatively and to derive dosimetric data for the individual patient. Furthermore, because of the chemical similarity of Y-EDTMP and Sm-EDTMP, these date should also be relevant to Sm-153-EDTMP.« less
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